A5100611205- Gut microbiota and health
- Epigenetics and DNA Methylation
- Botulinum Toxin and Related Neurological Disorders
- Viral Infections and Immunology Research
- Air Quality and Health Impacts
- Lung Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Probiotics and Fermented Foods
- Cancer Mechanisms and Therapy
- Clostridium difficile and Clostridium perfringens research
- Cancer-related gene regulation
- Parkinson's Disease Mechanisms and Treatments
- HIV/AIDS Research and Interventions
- Reproductive Biology and Fertility
- Tryptophan and brain disorders
- Gastric Cancer Management and Outcomes
- Diet and metabolism studies
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Medical Research and Treatments
- Lung Cancer Research Studies
- Cancer Cells and Metastasis
- IL-33, ST2, and ILC Pathways
Kunming Medical University
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
First Affiliated Hospital of Dalian Medical University
2025
Zhejiang Chinese Medical University
2025
Hangzhou Xixi hospital
2025
Jiangnan University
2021-2025
Dalian Medical University
2000-2025
Harbin Medical University
2025
Second Affiliated Hospital of Harbin Medical University
2025
Wuxi Fourth People's Hospital
2025
Abstract N-staging is a determining factor for prognostic assessment and decision-making stage-based cancer therapeutic strategies. Visual inspection of whole-slides intact lymph nodes currently the main method used by pathologists to calculate number metastatic (MLNs). Moreover, even at same N stage, outcome patients varies dramatically. Here, we propose deep-learning framework analyzing node whole-slide images (WSIs) identify tumor regions, then uncover tumor-area-to-MLN-area ratio...
We investigated the effects of glucose concentration in serum-free media on proliferative growth response a cultured murine mesangial cell line. Raising ambient D-glucose from 100 mg/dl to 450 stimulated proliferation after 24 48 hours but had inhibitory effect 72 96 incubation. This biphasic high was not mediated by elevated osmolarity medium and did occur when L-glucose used. The early phase glucose-induced associated with increased expression immediate genes c-myc egr-1 as well induction...
The microbiome has been implicated in the initiation and persistence of inflammatory bowel disease. Despite fact that diet is one most potent modulators composition function dietary intervention first-line therapy for treating pediatric Crohn's disease, relationships between diet-induced remission, enteropathy, are poorly understood. Here, we leverage a naturally-occurring canine model chronic enteropathy exhibits robust remission following nutritional therapy, to perform longitudinal study...
AIM:To investigate the value of interleukin-8 (IL-8), a pro-inflammatory chemokine, in predicting prognosis pancreatic cancer. METHODS: Expression IL-8 and its receptor CXCR1was assessed by immunohistochemistry cancer chronic pancreatitis samples.Enzyme-linked immunosorbent assay was used to detect serum levels patients.Human tissues were heterotopically transplanted immune-deficiency mice evaluate effect on tumorigenesis samples.RESULTS: CXCR1 proteins both overexpressed adenocarcinoma...
Major depressive disorder (MDD) is a leading global psychiatric disease. MDD highly comorbid with gastrointestinal abnormalities, such as gut motility dysfunction. An effective strategy to manage depression and its accompanying symptoms warranted.Three probiotic strains (Bifidobacterium breve CCFM1025, Bifidobacterium longum CCFM687, Pediococcus acidilactici CCFM6432) had previously been validated in mice possess antidepressant-like potential. This study investigated the potential...
The polygenic nature of complex psychiatric disorders suggests a common pathway that may be involved in the down-regulation multiple genes through an epigenetic mechanism. To investigate role methylation down-regulating expression mRNAs associated with schizophrenia phenotype, we have adopted cell-culture model amenable to this line investigation. We administered methionine (2 mM) primary cultures cortical neurons prepared from embryonic day 16 mice and show treatment down-regulated reelin...
Abstract Background Pancreatic cancer is one of the most lethal cancers worldwide. The aim this study was to determine expression pattern, clinical significance, and biological functions Wnt5a in pancreatic cancer. Methods Immunohistochemistry performed examine 134 surgically resected adenocarcinoma adjacent normal tissues. Associations with clinicopathological factors cancer-specific survival were analyzed. effects overexpression or silencing on invasiveness epithelial-to-mesenchymal...
Despite the high worldwide prevalence of gallstone disease, role biliary microbiota in pathogenesis remains obscure. Next-generation sequencing offers advantages for systematically understanding human microbiota; however, there have been few such investigations microbiome. Here, we performed whole-metagenome shotgun (WMS) and 16S rRNA on bile samples from 15 Chinese patients with disease. Microbial communities most individuals were clustered into two types, according to relative enrichment...
// Guanzhen Yu 1, 2, * , Wenzheng Fang 7, Tian Xia 3, 6, Ying Chen 4, Yunshu Gao 5 Xiaodong Jiao 1 Suyun Huang 2 Jiejun Wang Zhaosheng Li 3 Keping Xie 6 Department of Medical Oncology, Changzheng Hospital, Shanghai 200070, China Neurosurgery, The University Texas MD Anderson Cancer Center, Houston, 77030, USA Gastroenterology, Changhai 200433, 4 Pathology, Qingdao, Shandong 266000, Hepatology & Nutrition, 7 Fuzhou General Clinical College Fujian University, Fuzhou, 350025, These authors have...
The influence of meteorological determinants on tuberculosis (TB) incidence remains severely under-discussed, especially through the perspective time series analysis. In current study, we used a distributed lag nonlinear model (DLNM) to analyze 10-year consecutive surveillance data. We found that, after effectively controlling for autocorrelation, changes in factors related temperature, humidity, wind and sunshine were significantly associated with subsequent fluctuations TB incidence:...
Rh2 is a rare ginsenoside and there are few reports of its effect on cognition compared with other similar molecules. This study aimed to establish the impact treatment improving scopolamine (Scop)‐induced memory deficits in mice illuminate underlying mechanisms. First, memory‐related behavior was evaluated using two approaches: object location recognition (OLR), based spontaneous activity, Morris water maze (MWM) task, an aversive stimulus. Our results suggested that effectively increased...
Abstract Background The maternal microbiome has emerged as an important factor in gestational health and outcome is associated with risk of preterm birth offspring morbidity. Epidemiological evidence also points to successive pregnancies—referred parity—as a for birth, infant mortality, impaired neonatal growth. Despite the fact that both parity are linked maternal-infant health, impact on remains largely unexplored, part due challenges studying humans. Results Using synchronized pregnancies...
The beneficial effect of short-chain fatty acids (SCFAs) on host health has been well recognized based the booming knowledge from gut microbiome research. role SCFA in influencing psychological function is highlighted recent years but not fully elucidated. In this study, SCFA-acylated starches were used to accomplish a sizeable intestine-targeted release SCFAs, and neurobehavioral, immunological, microbial effects further investigated. Acetylated-, butylated-, isobutylated-starch could...
Normal pregnancy involves numerous physiological changes, including changes in hormone levels, immune responses, and metabolism. Although several studies have shown that the gut microbiota may an important role progression of pregnancy, these findings been inconsistent, relationship between metabolites change dynamically during after remains to be clarified. In this longitudinal study, we comprehensively profiled temporal dynamics microbiota,
Abstract Background The putative tumor metastasis suppressor 1(MTSS1) is an actin-binding scaffold protein that has been implicated to play important role in carcinogenesis and cancer metastasis, yet its the development of gastric not well illustrated. In this study, we detected MTSS1 expression explored clinical significance cancer. Methods Immunohistochemistry was performed using tissue microarrays containing adenocarcinoma specimens from 1,072 Chinese patients with normal adjacent mucosa,...
Inflammation appears to be important in lung carcinogenesis among smokers, but its role never-smokers is not well established. We hypothesized that inflammatory medical conditions and gene polymorphisms interact increase cancer risk never-smokers. interviewed 433 Singaporean female never-smoker patients 1375 hospital controls, evaluated six the interleukin 1-β, 6 (IL6), cyclooxygenase-2, peroxisome proliferator-activated receptor-γ 1-β receptor antagonist (IL1RN) genes. Tuberculosis was...
SNAT1 is a subtype of the amino acid transport system A that has been implicated to play potential role in cancer development and progression, yet its breast remains unclear. In present study, we detected expression cancers explored underlying mechanism promoting carcinogenesis.RT-PCR Western blotting were performed analyze transcription protein levels cell lines fresh tissues. Tissue microarray blocks containing specimens obtained from 210 patients constructed. Expression these was analyzed...
Enterovirus 71 (EV71) infection can induce a series of syndromes including herpangina, viraemia, hand-foot-and-mouth disease and even death. Outbreaks EV71 have been reported periodically over the world caused great number casualties high medical expenditure. Some interferons (IFNs) used for treatment viral infections decades; however, conventional IFNs only display mild anti-EV71 activities. No effective drug is currently available infection. Here, we aimed to investigate whether some IFN...
Perineural invasion and immunosuppressive tumor microenvironment are the distinct features of pancreatic ductal adenocarcinoma (PDAC). Heterogeneous myeloid-derived suppressor cells (MDSCs) potent suppressors antitumor immunity, posing obstacles for cancer immunotherapy. Increasing evidences have demonstrated accumulation MDSCs in PDAC patients. However, role perineural existence novel MDSC subsets during remain unclear. This study found that lymphocytic cuffs were frequently present chronic...
Households in Xuanwei and Fuyuan, China, possess hazardous levels of fine particulate matter with an aerodynamic diameter <2.5 microns (PM2.5) polycyclic aromatic hydrocarbons (PAHs) from coal combustion. Previous studies found that increased exposure to PM2.5 benzo[a]pyrene (BaP; a PAH) were associated decreased mitochondrial DNA copy number (mtDNAcn), marker oxidative stress. We further evaluated these associations cross-sectional study 148 healthy non-smoking women Fuyuan. Personal BaP...
Abstract The crucial role of interferon (IFN) signaling is well known in the restriction or eradication pathogen invasion. Viruses take a variety ways to antagonize host defense through eliminating IFN-signaling intracellularly for decades. However, way by viruses target extracellularly has not been discovered. Infection both coronavirus SARS-CoV-2 and enterovirus 71 (EV71 EV-A71) can cause severe diseases such as neurological disorders even death children. 1–3 Here, we show evidence that...