A5038033276- Intracranial Aneurysms: Treatment and Complications
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Structural Engineering and Vibration Analysis
- Colorectal Cancer Treatments and Studies
- Wood Treatment and Properties
- Angiogenesis and VEGF in Cancer
- Structural Load-Bearing Analysis
- Advanced Memory and Neural Computing
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Heat Transfer and Boiling Studies
- Heat Transfer and Optimization
- PI3K/AKT/mTOR signaling in cancer
- Transition Metal Oxide Nanomaterials
- Cancer survivorship and care
- Cell Adhesion Molecules Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bamboo properties and applications
- Cancer-related molecular mechanisms research
- Cancer Treatment and Pharmacology
- Pain Management and Opioid Use
University of Electronic Science and Technology of China
2018-2025
Capital Medical University
2018-2025
Beijing Tian Tan Hospital
2019-2025
Guilin University of Electronic Technology
2009-2024
Anhui Normal University
2024
Shanghai Changzheng Hospital
2011-2023
Central South University of Forestry and Technology
2010-2023
Central South University
2010-2023
National Engineering Research Center of Electromagnetic Radiation Control Materials
2019-2023
Capital University
2023
<h3>Importance</h3> Patients with metastatic colorectal cancer (CRC) have limited effective and tolerable treatment options. <h3>Objective</h3> To evaluate the efficacy safety of oral fruquintinib, a vascular endothelial growth factor receptor (VEGFR) inhibitor, as third-line or later therapy in patients CRC. <h3>Design, Setting, Participants</h3> FRESCO (Fruquintinib Efficacy Safety 3+ Line Colorectal Cancer Patients) was randomized, double-blind, placebo-controlled, multicenter (28...
Abstract Purpose: We determined the expression of mammalian target rapamycin (mTOR) and its activated form, p-mTOR, in Chinese patients with gastric cancer clinical effects underlying mechanisms. Experimental Design: Tissue microarray blocks containing tissue matched noncancer specimens obtained from 1,072 were constructed. Expression total mTOR p-mTOR these was analyzed using immunohistochemical studies confirmed by Western blotting. Results: The overall rates overexpression 50.8% (545...
Previous cDNA microarrays indicated that CLDN1 ( claudin‐1 ) is an important gene for ovarian cancer‐initiating cell (OCIC) invasion and adhesion. Here, we show the downregulation of miR‐155 in OCICs correlates with overexpression suppression OCIC invasion. Luciferase assays indicate targets mRNA on 3′ UTR. protein expression were significantly decreased miR‐155‐OCICs. Proliferation Transwell migration suppresses proliferative invasive capacity OCICs. Furthermore, growth xenograft tumors....
Endostar™ (rh-endostatin, YH-16) is a new recombinant human endostatin developed by Medgenn Bioengineering Co. Ltd., Yantai, Shandong, P.R.China. Pre-clinical study indicated that YH-16 could inhibit tumor endothelial cell proliferation, angiogenesis and growth. Phase I phase II studies revealed was effective as single agent with good tolerance in clinical use.The current to compare the response rate , median ti me progression (TTP) ,clinical benefit andsafety patients advanced non-small...
// Guanzhen Yu 1, 2, * , Wenzheng Fang 7, Tian Xia 3, 6, Ying Chen 4, Yunshu Gao 5 Xiaodong Jiao 1 Suyun Huang 2 Jiejun Wang Zhaosheng Li 3 Keping Xie 6 Department of Medical Oncology, Changzheng Hospital, Shanghai 200070, China Neurosurgery, The University Texas MD Anderson Cancer Center, Houston, 77030, USA Gastroenterology, Changhai 200433, 4 Pathology, Qingdao, Shandong 266000, Hepatology & Nutrition, 7 Fuzhou General Clinical College Fujian University, Fuzhou, 350025, These authors have...
This study explored potential biomarkers associated with Lauren classification of gastric cancer. We screened microarray datasets on cancer information in GEO database, and compared differentially expressing genes between intestinal-type or diffuse-type Four sets data (GSE2669, GSE2680, GDS3438 GDS4007) were enrolled into analysis. By differential gene analysis, UBE2C, CDH1, CENPF, ERO1L, SCD, SOX9, CKS1B, SPP1, MMP11 ANLN identified as the top related to cancer, MGP, FXYD1, FAT4, SIPA1L2,...
Abstract Background The putative tumor metastasis suppressor 1(MTSS1) is an actin-binding scaffold protein that has been implicated to play important role in carcinogenesis and cancer metastasis, yet its the development of gastric not well illustrated. In this study, we detected MTSS1 expression explored clinical significance cancer. Methods Immunohistochemistry was performed using tissue microarrays containing adenocarcinoma specimens from 1,072 Chinese patients with normal adjacent mucosa,...
Abstract Background Increasing interest has been devoted to the expression and possible role of sex hormone receptors in gastric cancer, but most these findings are controversial. In present study, profile cancer their clinicopathological prognostic value were determined a large Chinese cohort. Methods The mRNA protein estrogen receptor alpha (ERα), beta (ERβ), progesterone (PR), androgen (AR) primary tumors corresponding adjacent normal tissues from 60 866 patients was detected by real-time...
// Guanzhen Yu 1,3,* , Aidong Zhou 1,* Jianfei Xue 1 Chen Huang 2 Xia Zhang 3 Shin-Hyuk Kang Wen-Tai Chiu Christina Tan Keping Xie 2,4 Jiejun Wang and Suyun 1,4 Departments of Neurosurgery, The University Texas MD Anderson Cancer Center, Houston, TX, USA Gastroenterology, Hepatology, Nutrition, Department Medical Oncology, Changzheng Hospital, Shanghai, People's Republic China 4 Program in Biology, Graduate School Biomedical Sciences at * These authors contributed equally to this work...
Annexin-1 contributes to the pathological consequence and sequelae of most serious human diseases including cardiovascular disease cancer. Although diverse roles in carcinogenesis have been postulated, its role gastrointestinal cancers still remains controversial. The mRNA protein expression profiles ANXA1 were studied esophageal, gastric, pancreatic, colorectal, liver, bile duct using Real-Time PCR, western blotting, immunohistochemistry. Gain/loss-of-function by pcDNA3.1-ANXA1 ANXA1-shRNA...
Temozolomide (TMZ) is considered a first line chemotherapy drug for glioblastoma (GBM). Unfortunately, the GBM without methylation of O6-methylguanine-DNA methyltransferase (MGMT), accounting about 70% all GBM, shows an inherent resistance to TMZ treatment. Aberrant accumulation neutral lipids, primarily triglycerides (TGs) and cholesteryl esters (CEs), in lipid droplets (LDs) has been recognized as metabolic vulnerability therapy. However, it not known whether MGMT affects GBM. Herein, we...
Molecular genetics is highly related with prognosis of high-grade glioma. Accordingly, the latest WHO guideline recommends that molecular subgroups genes, including IDH, 1p/19q, MGMT, TERT, EGFR, Chromosome 7/10, CDKN2A/B, need to be detected better classify glioma and guide surgery treatment. Unfortunately, there no preoperative or intraoperative technology available for accurate comprehensive subgrouping Here, we develop a deep learning-assisted fiber-optic Raman diagnostic platform rapid...
Glioblastoma (GBM) is one of the most lethal adult brain tumors with limited effective therapeutic options. Immunotherapy targeting B7-H3 (CD276) has shown promising efficacy in treatment gliomas. However, response to this varies among glioma patients due individual differences. It's necessary find an strategy improve immunotherapy for non-responders. In study, we demonstrated a strong correlation between aurora kinase A (AURKA) and CD276 expression tissue samples. Additionally, both AURKA...
Summary Purpose: Metastasis remains an incurable common complication in patients with gastric cancer. A variety of theories have been proposed to explain the inefficiency metastatic process. To compare protein expression metastasis‐related genes (nm23, KISS1, KAI1 and p53) between primary tumours may be useful illustrating these theories. Methods: Metastasis‐related tissue microarrays (including normal tissues, tumours, nodal metastases liver metastases) were constructed. The nm23, p53 lymph...
The incidence of premature ovarian failure (POF), a condition causing amenorrhea and hypergonadotropic hypoestrogenism in women before the age 40, has been increasing recent years. As an irreversible pathological change, improved treatment strategies for this disease are urgently needed. In study, type microRNA (miR-17-3p) was used to guide differentiation human-induced pluripotent stem (iPS) cells into hormone-sensitive epithelial (OSE)-like vitro. To prevent their morphological...