A5101445445- Machine Learning and Data Classification
- Ferroelectric and Piezoelectric Materials
- Machine Learning and Algorithms
- Semiconductor materials and devices
- Electronic and Structural Properties of Oxides
- Domain Adaptation and Few-Shot Learning
- Nanoplatforms for cancer theranostics
- Multiferroics and related materials
- Anomaly Detection Techniques and Applications
- Advanced Memory and Neural Computing
- Imbalanced Data Classification Techniques
- Nanoparticle-Based Drug Delivery
- Acoustic Wave Resonator Technologies
- Ferroelectric and Negative Capacitance Devices
- Adversarial Robustness in Machine Learning
- Text and Document Classification Technologies
- Face and Expression Recognition
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanowire Synthesis and Applications
- Photoacoustic and Ultrasonic Imaging
- Advancements in Semiconductor Devices and Circuit Design
- Graphene research and applications
- Advanced Multi-Objective Optimization Algorithms
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
Xi'an Jiaotong University
2016-2025
Zhengzhou University
2025
Shandong University of Technology
2025
University of Technology Sydney
2024
RIKEN Center for Advanced Intelligence Project
2017-2024
Hefei University of Technology
2024
Fujian Medical University
2019-2024
Annoroad Gene Technology (China)
2024
Ministry of Education of the People's Republic of China
2023
RIKEN
2019-2022
Deep learning with noisy labels is practically challenging, as the capacity of deep models so high that they can totally memorize these sooner or later during training. Nonetheless, recent studies on memorization effects neural networks show would first training data clean and then those labels. Therefore in this paper, we propose a new paradigm called ''Co-teaching'' for combating Namely, train two simultaneously, let them teach each other given every mini-batch: firstly, network feeds...
Chemodynamic therapy (CDT) employs Fenton catalysts to kill cancer cells by converting intracellular H2O2 into hydroxyl radical (•OH), but endogenous is insufficient achieve satisfactory anticancer efficacy. Despite tremendous efforts, engineering CDT agents with specific and efficient self-supplying ability remains a great challenge. Here, we report the fabrication of copper peroxide (CP) nanodot, which first example Fenton-type metal nanomaterial, its use as an activatable agent for...
A multifunctional theranostic platform based on photosensitizer-loaded plasmonic vesicular assemblies of gold nanoparticles (GNPs) is developed for effective cancer imaging and treatment. The vesicles (GVs) composed a monolayer assembled GNPs show strong absorbance in the near-infrared (NIR) range 650-800 nm, as result coupling effect between neighboring membranes. NIR absorption capability encapsulating photosensitizer Ce6 GVs enable trimodality fluorescence/thermal/photoacoustic...
Abstract The hierarchical assembly of gold nanoparticles (GNPs) allows the localized surface plasmon resonance peaks to be engineered near‐infrared (NIR) region for enhanced photothermal therapy (PTT). Herein we report a novel theranostic platform based on biodegradable plasmonic nanovesicles photoacoustic (PA) imaging and PTT. disulfide bond at terminus PEG‐ b ‐PCL block‐copolymer graft enables dense packing GNPs during process induces ultrastrong coupling between adjacent GNPs. strong NIR...
Chlorin e6 conjugated gold nanostars (GNS-PEG-Ce6) are used to perform simultaneous photodynamic/plasmonic photothermal therapy (PDT/PPTT) upon single laser irradiation. The early-phase PDT effect is coordinated with the late-phase PPTT obtain synergistic anticancer efficiency. prepared GNS-PEG-Ce6 shows excellent water dispersibility, good biocompatibility, enhanced cellular uptake and remarkable efficiency irradiation in vivo.
The emergence of photoluminescent carbon-based nanomaterials has shown exciting potential in the development benign nanoprobes. However, vivo kinetic behaviors these particles that are necessary for clinical translation poorly understood to date. In this study, fluorescent carbon dots (C-dots) were synthesized and effect three injection routes on their fate was explored by using both near-infrared fluorescence positron emission tomography imaging techniques. We found C-dots efficiently...
It is essential to control the size and morphology of nanoparticles strictly in nanomedicine. Protein cages offer significant potential for templated synthesis inorganic nanoparticles. In this study, we successfully synthesized ultrasmall copper sulfide (CuS) inside cavity ferritin (Fn) nanocages by a biomimetic method. The uniform CuS–Fn (CuS–Fn NCs) showed strong near-infrared absorbance high photothermal conversion efficiency. quantitative ratiometric photoacoustic imaging (PAI), NCs...
We report a hybrid reduced graphene oxide (rGO)-loaded ultrasmall plasmonic gold nanorod vesicle (rGO-AuNRVe) (∼65 nm in size) with remarkably amplified photoacoustic (PA) performance and photothermal effects. The also exhibits high loading capacity of doxorubicin (DOX), as both the cavity large surface area encapsulated rGO can be used for DOX, making it an excellent drug carrier. loaded DOX is released sequentially: near-infrared heating induces release from vesicular cavity, intracellular...
Learning with noisy labels is one of the hottest problems in weakly-supervised learning. Based on memorization effects deep neural networks, training small-loss instances becomes very promising for handling labels. This fosters state-of-the-art approach "Co-teaching" that cross-trains two networks using trick. However, increase epochs, converge to a consensus and Co-teaching reduces self-training MentorNet. To tackle this issue, we propose robust learning paradigm called Co-teaching+, which...
A new kind of ultrasmall dissociable AuNR@PEG/PLGA vesicles (≈60 nm) (AuNR = gold nanorod; PEG poly(ethylene glycol); PLGA poly(lactic-co-glycolic acid)) assembled from small AuNRs (dimension: ≈8 nm × 2 is reported. They exhibit several striking features: prolonged circulation and prominent tumor accumulation; rapid excretion the body as AuNR@PEG after therapy; enhanced photoacoustic photo thermal properties; high photothermal cancer therapy efficacy.
From only positive (P) and unlabeled (U) data, a binary classifier could be trained with PU learning, in which the state of art is unbiased learning. However, if its model very flexible, empirical risks on training data will go negative, we suffer from serious overfitting. In this paper, propose non-negative risk estimator for learning: when getting minimized, it more robust against overfitting, thus are able to use flexible models (such as deep neural networks) given limited P data....
Graphene, a 2-dimensional carbon nanomaterial, has attracted wide attention in biomedical applications, owing to its intrinsic physical and chemical properties.In this work, photosensitizer molecule, 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-alpha (HPPH or Photochlor®), is loaded onto polyethylene glycol (PEG)-functionalized graphene oxide (GO) via supramolecular π-π stacking.The obtained GO-PEG-HPPH complex shows high HPPH loading efficiency.The vivo distribution delivery were tracked...
The combination of reactive oxygen species (ROS)-involved photodynamic therapy (PDT) and chemodynamic (CDT) holds great promise for enhancing ROS-mediated cancer treatment. Herein, we reported an in situ polymerized hollow mesoporous organosilica nanoparticle (HMON) biocatalysis nanoreactor to integrate the synergistic effect PDT/CDT pancreatic ductal adenocarcinoma HPPH photosensitizer was hybridized within framework HMON via "in growth" approach. Then, cavity HMONs exploited as a...
Combination of photoacoustic (PA) and ultrasound (US) imaging offers high spatial resolution images with deep tissue penetration, which shows great potential in applications medical imaging. Development PA/US dual-contrast agents contrast excellent biocompatibility is interest. Herein, an organic semiconducting nanodroplet, PS-PDI-PAnD, developed by stabilizing low-boiling-point perfluorocarbon (PFC) droplet a photoabsorber agent perylene diimide (PDI) molecules coencapsulating the...
A versatile biomimetic theranostic agent based on magnetic melanin nanoparticles is developed for positron-emission tomography/magnetic resonance/photoacoustic/photothermal multimodal-imaging-guided cancer photothermal therapy and UV γ-irradiation protection. As a service to our authors readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed may be re-organized online delivery, but not copy-edited or typeset. Technical support issues...
Abstract The delivery of therapeutic peptides for diabetes therapy is compromised by short half-lives drugs with the consequent need multiple daily injections that reduce patient compliance and increase treatment cost. In this study, we demonstrate a smart exendin-4 (Ex4) device based on microneedle (MN)-array patches integrated dual mineralized particles separately containing Ex4 glucose oxidase (GOx). particle-based system can specifically release while immobilizing GOx as result...
Semiconducting molecules of perylene diimide (PDI) with strong light absorption properties in the near-infrared region and good biocompatibility have received increasing attention field theranostics, especially as photoacoustic (PA) imaging agents. Herein, we report a series [64Cu]-labeled PDI nanoparticles (NPs) different sizes (30, 60, 100, 200 nm) dual positron emission tomography (PET) PA probes photothermal therapy The precise size control NPs can be achieved by adjusting initial...
Using positron emission tomography (PET) imaging to monitor and quantitatively analyze the delivery localization of Au nanomaterials (NMs), a widely used photothermal agent, is essential optimize therapeutic protocols achieve individualized medicine avoid side effects. Coupling radiometals NMs via chelator faces challenges possible detachment as well surface property changes NMs. In this study, we reported simple general chelator-free 64Cu radiolabeling method by chemically reducing on...
Abstract The hierarchical assembly of gold nanoparticles (GNPs) allows the localized surface plasmon resonance peaks to be engineered near‐infrared (NIR) region for enhanced photothermal therapy (PTT). Herein we report a novel theranostic platform based on biodegradable plasmonic nanovesicles photoacoustic (PA) imaging and PTT. disulfide bond at terminus PEG‐ b ‐PCL block‐copolymer graft enables dense packing GNPs during process induces ultrastrong coupling between adjacent GNPs. strong NIR...
We report a camptothecin (CPT) prodrug that was well formulated in solution and rapidly transformed into long-circulating nanocomplexes vivo for highly efficient drug delivery effective cancer therapy. Specifically, using redox-responsive disulfide linker, CPT conjugated with an albumin-binding Evans blue (EB) derivative; the resulting amphiphilic CPT-ss-EB self-assembled nanostructures aqueous solution, thus conferring high solubility stability. By binding to endogenous albumin, 80 nm...
Construction of self-illuminating semiconducting nanocrystals, also called quantum dots (QDs), has attracted much attention recently due to their potential as highly sensitive optical probes for biological imaging applications. Here we prepared a QD system by doping positron-emitting radionuclide (64)Cu into CdSe/ZnS core/shell QDs via cation-exchange reaction. The (64)Cu-doped exhibit efficient Cerenkov resonance energy transfer (CRET). signal can accurately reflect the biodistribution...