A5039854676- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Nanoparticles: synthesis and applications
- Carbon and Quantum Dots Applications
- Graphene and Nanomaterials Applications
- Click Chemistry and Applications
- Electrochemical sensors and biosensors
- Gold and Silver Nanoparticles Synthesis and Applications
- Molecular Junctions and Nanostructures
- Urinary Tract Infections Management
- Ocular Surface and Contact Lens
- Antibiotic Resistance in Bacteria
- Chemical Synthesis and Analysis
- Quantum Dots Synthesis And Properties
- Synthesis and Biological Evaluation
- Layered Double Hydroxides Synthesis and Applications
- Synthesis and Catalytic Reactions
- Advanced Photocatalysis Techniques
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Clay minerals and soil interactions
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- Chemical Synthesis and Reactions
Qingdao University of Science and Technology
2018-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
University of Houston
2015-2020
Inner Mongolia University of Technology
2019-2020
Changzhou University
2013-2014
University of Science and Technology of China
2001
Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by diversity synergy drug functions as well DFU microenvironment itself. Herein, an ultrasound-augmented multienzyme-like nanozyme hydrogel spray was developed using hyaluronic acid encapsulated l-arginine ultrasmall gold nanoparticles Cu1.6O coloaded phosphorus doped graphitic...
Abstract Plasmon stimulation represents an appealing way to modulate enzyme mimic functions, but utilization efficiency of plasmon excitation remains relatively low. To overcome this drawback, a heterojunction composite based on graphdiyne nanowalls wrapped hollow copper sulfide nanocubes (CuS@GDY) with strong localized surface resonance (LSPR) response in the near‐infrared (NIR) region is developed. This nanozyme can concurrently harvest LSPR induced hot carriers and produce photothermal...
Abstract Metal peroxide nanoparticles designed to elevate the oxidative stress are considered a promising nanotherapeutics in biomedical applications, including chemotherapy, photodynamic therapy, and bacterial disinfection. However, their lack of specificity towards therapeutic target can cause toxic side effects healthy tissues. Here, silver (Ag 2 O NPs) capable controlled reactive oxygen species (ROS) release synthesized. The bactericidal Ag + ions ROS is strictly regulated by external...
Abstract Wound infection is arguably the most common, and potentially devastating, complication of wound healing process. The ideal treatment strategy has to eliminate bacteria, alleviate inflammation, promote skin formation. Herein, a multifunctional heterostructure designed consisting ultrasmall platinum–ruthenium nanoalloys porous graphitic carbon nitride C 3 N 5 nanosheets (denoted as PtRu/C ), which concurrently possesses piezoelectric enhanced oxidase ‐mimic nanozyme activity...
Inflammatory bowel disease (IBD) affects millions of individuals worldwide annually. Enteric reactive oxygen species (ROS) play critical roles in the physiology and pathology IBD. Nanozymes hold great promise for treatment IBD because their exceptional ability to regulate redox homeostasis during ROS-related inflammation. However, rapid development orally administered, acid-tolerant, antioxidant nanozymes therapy is challenging. Here, a nine-tier high-throughput screening strategy...
Multienzyme-like nanozymes are nanomaterials with multiple enzyme-like activities and the focus of nanozyme research owing to their ability facilitate cascaded reactions, leverage synergistic effects, exhibit environmentally responsive selectivity. However, multienzyme-like varying under different conditions, making them difficult precisely regulate according design requirements. Moreover, individual activity in a may accelerate, compete, or antagonize each other, rendering overall complex...
Ulcerative colitis (UC) is a chronic gastrointestinal inflammatory disorder with rising prevalence. Due to the recurrent and difficult-to-treat nature of UC symptoms, current pharmacological treatments fail meet patients' expectations. This study presents machine learning-assisted high-throughput screening strategy expedite discovery efficient nanozymes for treatment. Therapeutic requirements, including antioxidant property, acid stability, zeta potential, are quantified predicted by using...
A copper-catalyzed click reaction inside living mammalian cells is demonstrated with the use of a cell-penetrating peptide-tethered Cu<sup>I</sup> ligand.
Abstract From manufacture to disposal, the interaction of graphdiyne based nanomaterials with living organisms is inevitable and crucial. However, cytotoxic properties this novel carbon nanomaterial are rarely investigated, mechanisms behind their cytotoxicity totally unknown. In study, antibacterial activity (GDY) oxide (GDYO) reported. GDY capable inhibiting broad‐spectrum bacterial growth while exerting moderate on mammalian cells. comparison, GDYO exhibits lower than that GDY. Then an...
The copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is a powerful tool for bioconjugation of biomolecules, particularly proteins and peptides. major drawback limiting the use CuAAC in biological systems copper-mediated formation reactive oxygen species (ROS), leading to oxidative degradation or From studies on limited number peptides, it known that, general, copper mediated damage associated with coordination environment solvent accessibility. However, there lack data help...
Reactive oxygen species (ROS)-induced nanosystems represent one of the most essential, efficient, and encouraging nanobactericides for eliminating bacterial infection concerning increasing resistance threats existing antibiotics. Among them, Fenton-type metal peroxide nanoparticles are exciting nanomaterials with intriguing physiochemical properties, yet study this antimicrobial agent is still in its infancy. Herein, a robust pH-responsive Fenton nanosystem constructed by assembly copper...
Graphdiyne (GDY) has been considered as an appealing electrode material for electrochemical sensing because of its alkyne-rich structure and high degrees π-conjugation, which shows great affinity to heavy metal ions pollutant molecules via d−π π–π interactions. However, the low surface area poor conductivity bulk GDY limit performance. Herein, a two-dimensional ultrathin GDY/graphene (GDY/G) nanostructure was synthesized used sensing. Graphene plays role epitaxy template few-layered growth...
Plasmon stimulation is an intriguing method to modulate the enzyme-mimic functions of nanomaterials, while utilization plasmon excitation remains low efficiency. Herein, by loading nitrogen-doped graphdiyne quantum dots (N-GDQDs) onto gold–silver nanocages (AuAg NCs), hollow cube-shaped N-GDQDs/AuAg NC heterostructures with strong local surface resonance (LSPR) response in near-infrared (NIR) region are reported. This nanozyme can concurrently harvest LSPR-induced hot carriers and produce...
Nanozymes are promising new-generation antibacterial agents owing to their low cost, high stability, broad-spectrum activity, and minimal antimicrobial resistance. However, the inherent catalytic activity of nanozymes tends limit efficacy. Herein, a heterostructure zinc oxide nanorod@graphdiyne nanosheets (ZnO@GDY NR) with unparallel piezocatalytic enzyme mimic is reported, which concurrently possesses intrinsic peroxidase-like strong piezoelectric responses effectively promotes...
Androgenetic alopecia (AGA) is a common form of hair loss, which mainly caused by oxidative stress induced dysregulation follicles (HF). Herein, highly efficient manganese thiophosphite (MnPS3) based superoxide dismutase (SOD) mimic was discovered using machine learning (ML) tools. Remarkably, the IC50 MnPS3 3.61 μg·mL–1, up to 12-fold lower than most reported SOD-like nanozymes. Moreover, microneedle patch (MnMNP) constructed treat AGA that could diffuse into deep skin where HFs exist and...
Ferroptosis–apoptosis, a new modality of induced cell death dependent on reactive oxygen species, has drawn tremendous attention in the field nanomedicine. A metal-free ferroptosis–apoptosis inducer was reported based boron and nitrogen codoped graphdiyne (BN-GDY) that possesses efficient glutathione (GSH) depletion capability concurrently induces ferroptosis by deactivation GSH-dependent peroxidases 4 (GPX4) apoptosis downregulation Bcl2. The high catalytic activity BN-GDY is explicated...