A5050689835- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Advanced Nanomaterials in Catalysis
- Endoplasmic Reticulum Stress and Disease
- interferon and immune responses
- Nanoplatforms for cancer theranostics
- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Advanced biosensing and bioanalysis techniques
- Cell death mechanisms and regulation
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Nanocluster Synthesis and Applications
- Adenosine and Purinergic Signaling
- RNA Interference and Gene Delivery
- Cancer Research and Treatments
- Diabetes and associated disorders
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Graphene and Nanomaterials Applications
Huashan Hospital
2015-2025
Fudan University
2015-2025
John Brown University
2024-2025
Regend Therapeutics (China)
2024
Brown University
2009-2024
Shanghai University
2024
Zhongshan Hospital
2012-2023
Fifth Hospital In Wuhan
2020-2023
Wuhan University
2020-2023
Providence College
2012-2022
Abstract Posttranslational neddylation of cullins in the Cullin-Ring E3 ligase (CRL) complexes is needed for proteolytic degradation CRL substrates, whose accumulation induces cell-cycle arrest, apoptosis, and senescence. The Nedd8-activating enzyme (NAE) critical their growth-promoting function. Recently, anticancer small molecule MLN4924 currently phase I trials was determined to be an inhibitor NAE that blocks cullin inactivates CRL, triggering substrates trigger senescence cancer cells....
Treatment of diabetic foot ulcers (DFU) needs to reduce inflammation, relieve hypoxia, lower blood glucose, promote angiogenesis, and eliminate pathogenic bacteria, but the therapeutic efficacy is greatly limited by diversity synergy drug functions as well DFU microenvironment itself. Herein, an ultrasound-augmented multienzyme-like nanozyme hydrogel spray was developed using hyaluronic acid encapsulated l-arginine ultrasmall gold nanoparticles Cu1.6O coloaded phosphorus doped graphitic...
Abstract Plasmon stimulation represents an appealing way to modulate enzyme mimic functions, but utilization efficiency of plasmon excitation remains relatively low. To overcome this drawback, a heterojunction composite based on graphdiyne nanowalls wrapped hollow copper sulfide nanocubes (CuS@GDY) with strong localized surface resonance (LSPR) response in the near‐infrared (NIR) region is developed. This nanozyme can concurrently harvest LSPR induced hot carriers and produce photothermal...
Abstract Metal peroxide nanoparticles designed to elevate the oxidative stress are considered a promising nanotherapeutics in biomedical applications, including chemotherapy, photodynamic therapy, and bacterial disinfection. However, their lack of specificity towards therapeutic target can cause toxic side effects healthy tissues. Here, silver (Ag 2 O NPs) capable controlled reactive oxygen species (ROS) release synthesized. The bactericidal Ag + ions ROS is strictly regulated by external...
Abstract Wound infection is arguably the most common, and potentially devastating, complication of wound healing process. The ideal treatment strategy has to eliminate bacteria, alleviate inflammation, promote skin formation. Herein, a multifunctional heterostructure designed consisting ultrasmall platinum–ruthenium nanoalloys porous graphitic carbon nitride C 3 N 5 nanosheets (denoted as PtRu/C ), which concurrently possesses piezoelectric enhanced oxidase ‐mimic nanozyme activity...
Inflammatory bowel disease (IBD) affects millions of individuals worldwide annually. Enteric reactive oxygen species (ROS) play critical roles in the physiology and pathology IBD. Nanozymes hold great promise for treatment IBD because their exceptional ability to regulate redox homeostasis during ROS-related inflammation. However, rapid development orally administered, acid-tolerant, antioxidant nanozymes therapy is challenging. Here, a nine-tier high-throughput screening strategy...
Ulcerative colitis (UC) is a chronic gastrointestinal inflammatory disorder with rising prevalence. Due to the recurrent and difficult-to-treat nature of UC symptoms, current pharmacological treatments fail meet patients' expectations. This study presents machine learning-assisted high-throughput screening strategy expedite discovery efficient nanozymes for treatment. Therapeutic requirements, including antioxidant property, acid stability, zeta potential, are quantified predicted by using...
Plasmon stimulation is an intriguing method to modulate the enzyme-mimic functions of nanomaterials, while utilization plasmon excitation remains low efficiency. Herein, by loading nitrogen-doped graphdiyne quantum dots (N-GDQDs) onto gold–silver nanocages (AuAg NCs), hollow cube-shaped N-GDQDs/AuAg NC heterostructures with strong local surface resonance (LSPR) response in near-infrared (NIR) region are reported. This nanozyme can concurrently harvest LSPR-induced hot carriers and produce...
Nanozymes are promising new-generation antibacterial agents owing to their low cost, high stability, broad-spectrum activity, and minimal antimicrobial resistance. However, the inherent catalytic activity of nanozymes tends limit efficacy. Herein, a heterostructure zinc oxide nanorod@graphdiyne nanosheets (ZnO@GDY NR) with unparallel piezocatalytic enzyme mimic is reported, which concurrently possesses intrinsic peroxidase-like strong piezoelectric responses effectively promotes...
Androgenetic alopecia (AGA) is a common form of hair loss, which mainly caused by oxidative stress induced dysregulation follicles (HF). Herein, highly efficient manganese thiophosphite (MnPS3) based superoxide dismutase (SOD) mimic was discovered using machine learning (ML) tools. Remarkably, the IC50 MnPS3 3.61 μg·mL–1, up to 12-fold lower than most reported SOD-like nanozymes. Moreover, microneedle patch (MnMNP) constructed treat AGA that could diffuse into deep skin where HFs exist and...
Ferroptosis–apoptosis, a new modality of induced cell death dependent on reactive oxygen species, has drawn tremendous attention in the field nanomedicine. A metal-free ferroptosis–apoptosis inducer was reported based boron and nitrogen codoped graphdiyne (BN-GDY) that possesses efficient glutathione (GSH) depletion capability concurrently induces ferroptosis by deactivation GSH-dependent peroxidases 4 (GPX4) apoptosis downregulation Bcl2. The high catalytic activity BN-GDY is explicated...
Abstract Keratitis, an inflammation of the cornea caused by bacterial or fungal infections, is one leading causes severe visual disability and blindness. Keratitis treatment requires both prevention infection reduction inflammation. However, owing to their limited therapeutic functions, in addition ocular barrier, existing conventional medications are characterized poor efficacy low bioavailability, requiring high dosages frequent topical treatment, which represents a burden on patients...
Ferroptosis is a regulated cell death nexus linking metabolism, redox biology and diseases including cancer. The aim of the present study was to identify ferroptosis-related gene prognostic signature for pancreatic cancer (PCa) by systematic analysis transcriptional profiles from Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx). Altogether 14 ferroptosis-relevant genes with potential values were identified, based on which risk score formula constructed. According scores, we...
Chitinase 3 like 1 (CHI3L1) is the prototypic chitinase-like protein mediating inflammation, cell proliferation, and tissue remodeling. Limited data suggest CHI3L1 elevated in human pulmonary arterial hypertension (PAH) associated with disease severity. Despite its importance as a regulator of injury/repair responses, relationship between vascular remodeling not well understood. We hypothesize that signaling pathways contribute to responses occur (PH). examined plasma levels severity PH...
Abstract Ankyrin‐repeat proteins with a suppressor of cytokine signaling box (ASB) belong to the E3 ubiquitin ligase family. 18 ASB members have been identified whose biological functions are mostly unexplored. Here, we discovered that ASB3 was essential for hepatocellular carcinoma (HCC) development and high expression predicted poor clinical outcomes. silencing induced HCC cell growth arrest apoptosis in vitro vivo. Liver‐specific deletion Asb3 gene suppressed diethylnitrosamine...
Abstract The tumor-suppressor gene cyclin-dependent kinase inhibitor 1B (P27) is downregulated in gastric cancer cells mainly through proteolytic degradation mediated by the SKP-Cullin1-F-Box (SCF) complex. But correlation between its downregulation and prognosis still remains indefinite. MLN4924, an anti-tumor agent, which suppresses SCF complex inhibiting Cullin1 neddylation, emerges as a promising tool to elucidate functions cells. In this study, MLN4924 induced significant growth...
// Bin Lv 1 , Chunhua Song 2 Lijun Wu Qi Zhang 1, 3 Daisen Hou Ping Chen Shunji Yu Zhicheng Wang 4 Yiwei Chu 5 Jun Dongqin Yang Jie Liu Department of Digestive Diseases Huashan Hospital, Fudan University, Shanghai, China Pediatrics, Pennsylvania State University College Medicine, Hershey, PA, USA Institutes Biomedical Sciences Shanghai Medical School, Laboratory Medicine Immunology, College, Correspondence to: Yang, e-mail: kobesakura@163.com Liu, jieliu@fudan.edu.cn Keywords: netrin-4,...