A5086301136- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Bone Tumor Diagnosis and Treatments
- Vascular Malformations Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Head and Neck Surgical Oncology
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Research and Treatments
- Sarcoma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Cerebrospinal fluid and hydrocephalus
- Oral and Maxillofacial Pathology
- Spinal Fractures and Fixation Techniques
- Spinal Dysraphism and Malformations
- Amino Acid Enzymes and Metabolism
- Pituitary Gland Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Facial Nerve Paralysis Treatment and Research
- Neurosurgical Procedures and Complications
- Fetal and Pediatric Neurological Disorders
- Anesthesia and Neurotoxicity Research
- Nanoplatforms for cancer theranostics
- Radiomics and Machine Learning in Medical Imaging
- Nerve injury and regeneration
Beijing Tian Tan Hospital
2016-2025
Capital Medical University
2016-2025
National Clinical Research Center for Digestive Diseases
2014-2023
Beijing Institute of Neurosurgery
2009-2023
Capital University
2013-2023
Chinese Institute for Brain Research
2015-2020
Center for Cancer Research
2017-2019
National Institutes of Health
2017-2019
National Cancer Institute
2016-2019
Neurological Surgery
2015
The aim of this study was to evaluate the pre- and postoperative rehemorrhage risk, neurological function outcome, prognostic factors surgically treated brainstem cavernous malformations (CMs) with long-term follow-up.The authors conducted a retrospective review clinical data from 242 patients CMs that were between 1999 2010. Patient charts, imaging findings, outcomes examined.The included patients, male-to-female ratio 1.3 mean age 32.6 years. modified Rankin Scale scores on admission, at...
OBJECT.: Cerebral cavernous malformations have been studied widely, but the natural history of brainstem (CMs) is not well defined, and hemorrhages caused by CMs are devastating. The goal this study was to quantify hemorrhage risks functional outcomes patients with CMs.This prospective, longitudinal, cohort included diagnosed between 1985 2012. clinical courses all were recorded. Predictors overall untreated evaluated.A total 331 (46.5% female) included, a mean follow-up duration 6.5 years....
Heat shock protein peptide complex-96 (HSPPC-96) triggers adaptive and innate antitumor immune responses. The safety efficacy of HSPPC-96 vaccination was examined in patients with newly diagnosed glioblastoma multiforme (GBM).In this open-label, single-arm, phase I study, adult were vaccinated combination the standard treatment for GBM after surgical resection. Primary endpoints frequency adverse events progression-free survival (PFS) at 6 months. Secondary included overall (OS), PFS,...
Meningiomas are the most common adult primary tumor of central nervous system, but there no known effective medical therapies for recurrent meningioma, particularly World Health Organization grade II and III tumors. arise from meninges, located outside blood-brain barrier, therefore may be directly targeted by antibody-mediated immunotherapy. We found that programmed cell death ligand 1 (PD-L1) was highly expressed in multiple human malignant meningioma lines patient samples. PD-L1 with...
The goal of this study was to evaluate surgical outcomes pediatric brainstem cavernous malformations (CMs) and identify the risk factors associated with postoperative full recovery rebleeding.The clinical charts radiographs from a series 52 patients (37 male 15 female; mean age 12.2 years; range 1-17 years) who underwent surgery for CMs between 1996 2011 were reviewed. Follow-up evaluation measures obtained retrospectively. Neurological function evaluated using modified Rankin Scale (mRS)...
The aim of this study was to investigate the clinical appearance untreated pediatric brainstem cavernous malformations (CMs) and identify hemorrhage risks functional outcomes.All patients with a diagnosis CM between 1985 2012 were registered. chart radiographs recorded, follow-up evaluations obtained prospectively.A total 85 (69.4% male) included mean age 12.7 years. Sixty-seven (78.8%) had prior hemorrhage, 6 (7.1%) asymptomatic. There 15 midbrain lesions, 53 pons 17 medulla lesions. lesion...
Background: Intravenous and inhalational anesthesia might have different associations with long-term outcome in cancer patients, reports of adverse effects inhalation anesthesia. However, the patients high-grade glioma (HGG) are not known. Methods: This study investigated 154 who received propofol 140 sevoflurane for maintenance during HGG tumor resection. The primary outcomes were progression-free survival overall survival. Results: Median was 10 months (interquartile range [IQR], 6 to 18)...
Abstract Collision tumors of the sellar region are relatively uncommon and consist mainly more than one type pituitary adenoma or a cyst cystic tumor. The association craniopharyngioma is particularly rare. This study describes rare occurrence in which coexisted region. case involves 47-year-old woman who underwent transsphenoidal surgery with subtotal tumor resection reoperation using an interhemispheric transcallosal approach for total microsurgical because visual acuity her left eye had...
Surgical site infection (SSI) is a common complication following craniotomy that increases morbidity, mortality, and medical expenses. The objectives of this study were to determine the relevant risk factors associated with SSI after elective for brain tumor analyse treatments SSI.A retrospective nested case‒control was conducted using data from patients who underwent resection at Neurosurgical Oncology Department No. 6 Beijing Tiantan Hospital, Capital Medical University, between January...
Glioblastoma (GBM) is one of the most lethal adult brain tumors with limited effective therapeutic options. Immunotherapy targeting B7-H3 (CD276) has shown promising efficacy in treatment gliomas. However, response to this varies among glioma patients due individual differences. It's necessary find an strategy improve immunotherapy for non-responders. In study, we demonstrated a strong correlation between aurora kinase A (AURKA) and CD276 expression tissue samples. Additionally, both AURKA...