A5101904739- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Circular RNAs in diseases
- RNA modifications and cancer
- Inflammatory Biomarkers in Disease Prognosis
- Hepatitis B Virus Studies
- Lymphoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Colorectal and Anal Carcinomas
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Cancer Treatment and Pharmacology
- Cancer Research and Treatments
- Cancer-related gene regulation
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Gastrointestinal Tumor Research and Treatment
Soochow University
2015-2025
Changshu No.1 People's Hospital
2025
Henan Cancer Hospital
2023
Zhengzhou University
2023
Soochow University
2020-2022
The First People's Hospital of Changzhou
2014-2021
Jilin University
2018
Jiangsu Cancer Hospital
2018
Nanjing Medical University
2018
First Hospital of Jilin University
2018
Transarterial chemoembolization (TACE) is the current standard of treatment for unresectable intermediate-stage hepatocellular carcinoma (HCC). Brivanib, a selective dual inhibitor vascular endothelial growth factor and fibroblast signaling, may improve effectiveness TACE when given as an adjuvant to TACE. In this multinational, randomized, double-blind, placebo-controlled, phase III study, 870 patients with TACE-eligible HCC were planned be randomly assigned (1:1) after first receive either...
<h3>Importance</h3> Patients with metastatic colorectal cancer (CRC) have limited effective and tolerable treatment options. <h3>Objective</h3> To evaluate the efficacy safety of oral fruquintinib, a vascular endothelial growth factor receptor (VEGFR) inhibitor, as third-line or later therapy in patients CRC. <h3>Design, Setting, Participants</h3> FRESCO (Fruquintinib Efficacy Safety 3+ Line Colorectal Cancer Patients) was randomized, double-blind, placebo-controlled, multicenter (28...
Abstract Purpose: Radiofrequency ablation (RFA) has been shown to elicit tumor-specific T-cell immune responses, but is not sufficient prevent cancer progression. Here, we investigated immune-suppressive mechanisms limiting the efficacy of RFA. Experimental Design: We performed a retrospective case-controlled study on patients with synchronous colorectal liver metastases who had received primary tumor resection or without preoperative RFA for metastases. Tumor-infiltrating T cells and...
Purpose Trifluridine/tipiracil (TAS-102) was effective in patients with metastatic colorectal cancer (mCRC) a phase II Japanese trial. This regional trial evaluated the efficacy and safety of trifluridine/tipiracil Asian mCRC or without exposure to biologic therapy. Patients Methods randomized, double-blind, placebo-controlled, III conducted at 30 sites China, Republic Korea, Thailand. ≥ 18 years old histologically cytologically confirmed adenocarcinoma colon rectum known KRAS status who...
Abstract Systemic immune-inflammation index (SII), based on peripheral lymphocyte, neutrophil, and platelet counts, was recently investigated as a prognostic marker in several tumors. However, SII has not been reported esophageal squamous cell carcinoma (ESCC). We evaluated the value of 916 patients with ESCC who underwent radical surgery. Univariate multivariate analyses were calculated by Cox proportional hazards regression model. The time-dependent receiver operating characteristics (ROC)...
Abstract Circular RNA (circRNA) plays an important role in the development of human malignant tumors. Recently, increasing number circRNAs have been identified and investigated various However, expression pattern biological function colorectal cancer (CRC) still remain largely unexplored. In present study, hsa_circ_0009361 was significantly down-regulated CRC tissues cells. Low level promoted proliferation, epithelial–mesenchymal transition (EMT), migration, invasion Hsa_circ_0009361 as...
Inhibitory costimulatory molecule CD274 expresses in various cancers and contributes to cancer immune evasion by inhibiting T cell activation proliferation, yet the regulatory mechanisms for overexpression are poorly understood. In this study, we discovered a novel mechanism of expression regulated miR-570. A guanine-to-cytosine mutation at 3'-UTR mRNA led disrupting miR-570 binding. The mutations were widely observed sequencing 276 gastrointestinal (esophageal, gastric, colorectal,...
In patients with gastric cancer, the prognostic value of tumor-infiltrating lymphocytes (TILs) is still controversial. A meta-analysis was performed to evaluate TILs in cancer.We identify studies from PubMed, Embase and Cochrane Library assess effect cancer. Fixed-effects models or random-effects were used estimate pooled hazard ratios (HRs) for overall survival (OS) disease-free (DFS), which depend on heterogeneity.A total 31 observational including 4,185 enrolled. For subsets, amount CD8+,...
Abstract Aim Systemic inflammatory response is closely related to tumor progression. We retrospectively investigated relationships between systemic scores, C‐reactive protein/albumin (CRP/Alb) ratio (CAR) and clinical characteristics in advanced non–small‐cell lung cancer (NSCLC) 436 patients find better predictors of NSCLC prognosis. Methods Blood specimens were collected 1 week before treatment test for scores albumin. Patients’ overall survival (OS) was calculated via Kaplan–Meier method....
Abstract Programmed death‐1 ligand‐1 (PD‐L1), a member of the B7 family costimulatory molecules, plays an important role in regulations cellular and humoral immune responses. In this study, two mouse anti‐human PD‐L1 monoclonal antibodies named 10E10 2H11 were successfully generated further characterized. Monoclonal antibody bound to distinct epitope comparing available anti‐PD‐L1 on series malignant cell lines, activated T lymphocytes, B lymphocytes dendritic cells. Then, by using...
B-cell specific moloney leukemia virus insertion site 1 (Bmi-1) gene plays important roles in gastric cancer, but the epigenetic regulatory mechanism by microRNA (miRNA) and functional significance of Bmi-1 inhibition cancer remains elusive. In this study, we systematically investigated miRNA mediated suppression cancer. Our results show that expression miR-15a is significantly reduced protein levels are inversely correlated with (P = 0.034) patient samples. Functional studies revealed...
IL-1β is an essential factor of inflammation initiation, and it also promotes malignant transformation, indicating its tumorigenic property. We aimed to investigate the correlation between miR-144-3p as well their prognostic values in LUAD LUSC patients.The level both patients was significantly higher than that healthy donors (P < 0.001). In populations, with low had better prognosis high 0.001 P = 0.010, respectively). A549 cells, miR-144 showed biggest expression change (-4.38 fold) after...
Abstract Background Metastatic colorectal cancer (mCRC) patients with progressive disease after all available standard therapies need new medication for further treatment. Famitinib is a small-molecule multikinase inhibitor, promising anticancer activities. This multicenter, randomized, double-blinded, placebo-controlled, phase II clinical trial was designed to evaluate the safety and efficacy of famitinib in mCRC. Methods or placebo administered orally once daily. The primary endpoint...