A5025924882- Cancer-related molecular mechanisms research
- Developmental Biology and Gene Regulation
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Gene expression and cancer classification
- 3D Printing in Biomedical Research
- MicroRNA in disease regulation
- Retinal Diseases and Treatments
- Plant Molecular Biology Research
- Retinal Imaging and Analysis
- Microfluidic and Bio-sensing Technologies
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Cancer, Lipids, and Metabolism
- Molecular Biology Techniques and Applications
- Network Security and Intrusion Detection
- Animal Genetics and Reproduction
- Pregnancy and Medication Impact
- Innovative Microfluidic and Catalytic Techniques Innovation
- DNA Repair Mechanisms
- Single-cell and spatial transcriptomics
- Microfluidic and Capillary Electrophoresis Applications
- Neurobiology and Insect Physiology Research
- Anomaly Detection Techniques and Applications
- Genetics, Aging, and Longevity in Model Organisms
Central South University
2024-2025
Wind Power Engineering (Japan)
2022
Energy Storage Systems (United States)
2022
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2017-2020
Wenzhou Medical University
2017-2020
Second People's Hospital of Yunnan Province
2020
Kunming Medical University
2020
He University
2020
Hunan University
2018-2019
Kunming General Hospital of Chengdu Military Command
2014-2019
In vivo cross-linking studies suggest that the Drosophila transcription factor Bicoid (Bcd) binds to several thousand sites during early embryogenesis, but it is not clear how many of these binding events are functionally important. contrast, reporter gene have identified >60 Bcd-dependent enhancers, all which contain clusters consensus sequence TAATCC. These also TAATCC motifs (inactive fragments) failed drive activation. general, active fragments showed higher levels Bcd in and were...
The Bicoid (Bcd) transcription factor is distributed as a long-range concentration gradient along the anterior posterior (AP) axis of Drosophila embryo. Bcd required for activation series target genes, which are expressed at specific positions within gradient. Here we directly tested whether different thresholds establish relative its genes by flattening and systematically varying expression levels. Genome-wide profiles were used to estimate total number general correlation was found between...
Abstract We propose eight data transformations ( r , r2 rv rv2 l l2 lv and lv2 ) for RNA-seq analysis aiming to make the transformed sample mean be representative of distribution center since it is not always possible transform count satisfy normality assumption. Simulation studies showed that sets with small (e.g., nCases = nControls 3) or large size 100) limma based on from performed better than voom transformation in term accuracy, FDR, FNR. For datasets moderate 30 50), similarly...
KNN-Based outlier detection over IoT streaming data is a fundamental problem, which has many applications. However, due to its computational complexity, existing efforts cannot efficiently work in the data. In this paper, we propose novel framework named GAAOD (Grid-based Approximate Average Outlier Detection) support Firstly, introduces grid-based index manage summary information of It can self-adaptively adjust resolution cells, and achieve goal filtering objects that almost become...
Despite years of study, the precise mechanisms that control position-specific gene expression during development are not understood. Here, we analyze an enhancer element from even skipped (eve) gene, which activates and positions two stripes (stripes 3 7) in blastoderm stage Drosophila embryos. Previous genetic studies showed JAK-STAT pathway is required for full activation enhancer, whereas gap genes hunchback (hb) knirps (kni) placement boundaries both stripes. We show maternal zinc-finger...
Nucleotide excision repair (NER), the core mechanism of DNA pathway, was commonly used to maintain genomic stability and prevent tumorigenesis. Previous investigations have demonstrated that single nucleotide polymorphisms (SNPs) NER pathway genes were associated with various types cancer. However, there no research elucidating genetic association entire ovarian cancer susceptibility. Therefore, we conducted genotyping for 17 SNPs six (XPA, XPC, XPG, ERCC1, ERCC2, ERCC4) in 89 cases 356...
Radiation-induced lung injury (RILI) is a common and severe side effect of thoracic radiotherapy, which compromises patients' quality life. Recent studies revealed that early vascular injury, especially microvascular damage, played central role in the development RILI. For this reason, protection essential for RILI therapy. The ATP-sensitive K+ (KATP) channel an ATP-dependent with multiple subunits. protective KATP has been demonstrated some published studies. In work, we investigated on Our...
Abstract The interplay among microRNAs (miRNAs) plays an important role in the developments of complex human diseases. Co-expression networks can characterize interactions miRNAs. Differential correlation network is a powerful tool to investigate differences co-expression between cases and controls. To construct differential network, Fisher’s Z-transformation test usually used. However, requires normality assumption, violation which would result inflated Type I error rate. Several...
Cervical cancer is a commonly diagnosed among females. Polymorphisms in pre-microRNAs have been demonstrated to play critical roles cancer. However, the of pre-microRNA polymorphisms aetiology cervical not well documented. We genotyped eight 290 patients and 445 cancer-free female controls using quantitative polymerase chain reaction with TaqMan probes. To estimate association between risk cancer, an unconditional logistic regression model was used calculate odds ratio (OR) 95% confidence...
// Anqi Zhang 1, * , Ting-Yan Shi 2, Yuan Zhao 1 Junmiao Xiang Danyang Yu Zongwen Liang Chaoyi Xu Qiong Yue Hu Danhan Wang Jing He 3 and Ping Duan Department of Obstetrics Gynecology, The Second Affiliated Hospital Yuying Children's Wenzhou Medical University, 325027, Zhejiang, China 2 Zhongshan Hospital, Fudan Shanghai 200032, Pediatric Surgery, Guangzhou Institute Pediatrics, Women Center, 510623, Guangdong, These authors have contributed equally to this work Correspondence to: Duan,...
Abstract Methodological improvement to single‐cell manipulation is critical for exploring the fundamentals of cellular life and unraveling biological complexity. Although micro‐manipulation technologies capable precise cell localization have been widely established, scaling existing platforms highly efficient immobilization without sacrificing viability sample quantity has proven challenging. Here, a trapping arraying approach introduced by advancing performance microfluidic mechanical chip....
Background Juvenile Graves ophthalmopathy has a low prevalence and few relevant studies.Analyzing reviewing the clinical features therapeutic effectiveness of juvenile is helpful to its diagnosis management. Objective This study was evaluate characteristics management in children adolescents. Methods The data 54 eyes from 29 patients with who were diagnosed Shanghai Changzheng Hospital January 2007 December 2012 retrospectively analyzed.The ocular manifestations, thyroid...