A5100358742- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Gene expression and cancer classification
- RNA modifications and cancer
- Biomedical Text Mining and Ontologies
- Plant Gene Expression Analysis
- Plant Stress Responses and Tolerance
- Ferroptosis and cancer prognosis
- Plant biochemistry and biosynthesis
- Topic Modeling
- Plant Disease Management Techniques
- MicroRNA in disease regulation
- Supramolecular Self-Assembly in Materials
- Cancer Genomics and Diagnostics
- Advanced biosensing and bioanalysis techniques
- Bioinformatics and Genomic Networks
- Virus-based gene therapy research
- Autophagy in Disease and Therapy
- Molecular Biology Techniques and Applications
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- Natural Language Processing Techniques
- Peptidase Inhibition and Analysis
- Plant Genetic and Mutation Studies
- Photosynthetic Processes and Mechanisms
Central South University
2018-2025
Fujian Agriculture and Forestry University
2019-2025
Stomatology Hospital
2025
Guangzhou Medical University
2025
Xiangya Hospital Central South University
2025
Shanghai East Hospital
2020-2024
Gansu Agricultural University
2022-2024
Huazhong Agricultural University
2024
First Affiliated Hospital of Nanchang University
2024
Nanchang University
2017-2024
Ferroptosis, a form of regulated cell death (RCD) that relies on excessive reactive oxygen species (ROS) generation, Fe2+ accumulation, abnormal lipid metabolism and is involved in various organ ischemia/reperfusion (I/R) injury, expecially myocardium. Mitochondria are the powerhouses eukaryotic cells essential regulating multiple RCD. However, links between mitochondria ferroptosis still poorly understood. Salidroside (Sal), natural phenylpropanoid glycoside isolated from Rhodiola rosea,...
Abstract We propose eight data transformations ( r , r2 rv rv2 l l2 lv and lv2 ) for RNA-seq analysis aiming to make the transformed sample mean be representative of distribution center since it is not always possible transform count satisfy normality assumption. Simulation studies showed that sets with small (e.g., nCases = nControls 3) or large size 100) limma based on from performed better than voom transformation in term accuracy, FDR, FNR. For datasets moderate 30 50), similarly...
Abstract Self‐assembly in living cells represents one versatile strategy for drug delivery; however, it suffers from the limited precision and efficiency. Inspired by viral traits, we here report a cascade targeting‐hydrolysis‐transformation (THT) assembly of glycosylated peptides holistically resembling infection efficient cargo delivery combined tumor therapy. We design peptide via incorporating β‐galactose‐serine residue into bola‐amphiphilic sequences. Co‐assembling with two counterparts...
Circular RNAs, including circular exonic RNAs (circRNA), intronic (ciRNA) and exon-intron circRNAs (EIciRNAs), are a new type of noncoding RNAs. Growing shoots moso bamboo (Phyllostachys edulis) represent an excellent model fast growth their have not been studied yet. To understand the potential regulation we systematically characterized from eight different developmental stages rapidly growing shoots. Here, identified 895 subset mutually inclusive circRNA. These were generated 759...
Concept normalization, the task of linking textual mentions concepts to in an ontology, is challenging because ontologies are large. In most cases, annotated datasets cover only a small sample concepts, yet concept normalizers expected predict all ontology. this paper, we propose architecture consisting candidate generator and list-wise ranker based on BERT. The considers pairings allowing it make predictions for any concept, not just those seen during training. We further enhance approach...
Abscisic acid (ABA) is a very important hormone in plants. It regulates growth and development of plants plays an role biotic abiotic stresses. The Pyrabactin resistance 1-like (PYR/PYL) proteins play central ABA signal transduction pathways. working system PYL genes cucumber, economical vegetable (Cucumis sativus L.), has not been fully studied yet. Through bioinformatics, total 14 individual were identified Chinese long '9930' cucumber. Fourteen distributed on six chromosomes their encoded...
The common method of delivering CRISPR/Cas reagents for genome editing in plants involves Agrobacterium-mediated transformation or preassembled CRISPR/Cas9 ribonucleoprotein complex delivery (Woo et al., 2015; Toda 2019; Ye 2020). These methods require labor-intensive and time-consuming plant tissue culture processes (Huang 2022). Unfortunately, most exhibit extremely low efficiency callus induction regeneration; these technical challenges greatly hinder the application editing. Recent...
Multi-organ segmentation is a critical yet challenging task due to complex anatomical backgrounds, blurred boundaries, and diverse morphologies. This study introduces the Gradient-aware Adaptive Momentum Evolution Deep Snake (GAMED-Snake) model, which establishes novel paradigm for contour-based by integrating gradient-based learning with adaptive momentum evolution mechanisms. The GAMED-Snake model incorporates three major innovations: First, Distance Energy Map Prior (DEMP) generates...
<title>Abstract</title> Background Mandibular fractures are common in human activities, and the treatment recovery process complicated, which can easily lead to postoperative pulmonary complications (PPCs) patients. This study investigated risk factors for PPCs after mandibular fracture surgery using National Inpatient Sample database. Method Data were analyzed from (NIS) database, covered patients who underwent 2010 2019. The database included patient demographics, hospital characteristics,...
This study aimed to establish an immune-glycolysis-related prognostic signature (IGRPS) predict hepatocellular carcinoma (HCC) outcomes. Additionally, it explored the role of this in tumor immune microenvironment (TIME), glycolytic pathways, and immunotherapy. We analyzed RNA-seq, single-cell sequencing, immune- glycolysis-related gene datasets from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO). Using weighted co-expression network analysis (WGCNA), F-test, Cox regression, we...
Abstract Molecular mechanisms of virus-related diseases involve multiple factors, including viral mutation accumulation and integration a genome into the host DNA. With increasing attention being paid to virus-mediated pathogenesis development many useful technologies identify virus mutations (VMs) sites (VISs), much research on these topics is available in PubMed. However, knowledge VMs VISs widely scattered numerous published papers which lack standardization, curation. To address...
Plant glutathione peroxidases (GPXs) are important enzymes for removing reactive oxygen species in plant cells and closely related to the stress resistance of plants. This study identified
Despite significant progress achieved in artificial self-sorting solution, operating the body remains a considerable challenge. Here, we report an vivo peptide system via situ assembly evolution for combined cancer therapy. The
Endoplasmic reticulum (ER) stress results from imbalances in unfolded/misfolded proteins, contributing to a wide variety of human diseases. To better understand the mechanisms involved cellular response ER cardiomyocytes, we previously conducted genome-wide screening an vitro model rat which highlighted amino acid transporter heavy chain, member 2 (SLC3A2) as important factor stress. In present study, characterized role SLC3A2 during unfolded protein (UPR), one primary pathways activated...
Abstract Background Semantic categorization analysis of clinical trials eligibility criteria based on natural language processing technology is crucial for the task optimizing design and building automated patient recruitment system. However, most related researches focused English criteria, to best our knowledge, there are no studied Chinese criteria. Thus in this study, we aimed explore semantic categories Methods We downloaded registration files from website Clinical Trial Registry...
<h3>Background:</h3> Splicing patterns are critical for assessing clinical phenotype of mutations in the dystrophin gene. However, it is still unclear how to predict alternative splicing pathways such cases splice-site mutation <h3>Objective:</h3> To identify elements determining intron +1G→A <h3>Results:</h3> We found that exon 25 spliced out 25, resulting mild Becker muscular dystrophy, and a cryptic splice site within 45 was activated severe Duchenne dystrophy with 45. Furthermore, vitro...
Background: With the increasing development of biotechnology, many cancer solutions have been proposed nowadays. In recent years, Neo-peptides-based methods made significant contributions, with an essential prerequisite bindings between peptides and HLA molecules. However, binding is hard to predict, accuracy expected improve further. Methods: Therefore, we propose Crossed Feature Correction Network (CFCN) deep learning method, which can automatically extract adaptively learn discriminative...
Lotus (Nelumbo nucifera) is a large aquatic plant that accumulates pharmacologically significant benzylisoquinoline alkaloids (BIAs). However, little known about their biosynthesis and regulation. Here, we show the two group III WRKY transcription factors (TFs), NnWRKY70a NnWRKY70b, positively regulate BIA in lotus. Both NnWRKY70s are jasmonic acid (JA) responsive, with expression profiles highly correlated to concentration pathway gene expression. A dual-luciferase assay showed could...