A5100719417- Endoplasmic Reticulum Stress and Disease
- High Altitude and Hypoxia
- Autophagy in Disease and Therapy
- Pulmonary Hypertension Research and Treatments
- Heart Failure Treatment and Management
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- CRISPR and Genetic Engineering
- Trace Elements in Health
- Cardiovascular Function and Risk Factors
- RNA modifications and cancer
- S100 Proteins and Annexins
- RNA regulation and disease
- Inflammatory Biomarkers in Disease Prognosis
- Iron Metabolism and Disorders
- Cancer, Lipids, and Metabolism
- Chemotherapy-induced cardiotoxicity and mitigation
- Health, Environment, Cognitive Aging
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Health and Risk Factors
- GDF15 and Related Biomarkers
- Cardiac Fibrosis and Remodeling
- Frailty in Older Adults
- Diet and metabolism studies
Chinese PLA General Hospital
2016-2025
Tianjin First Center Hospital
2025
Tianjin Medical University
2025
Nankai University
2024-2025
Jilin Agricultural University
2016
Abstract Aims Diabetic cardiomyopathy (DCM) is a major cause of mortality in patients with diabetes, and the potential strategies for treating DCM are insufficient. Melatonin (Mel) has been shown to attenuate DCM, however, underlying mechanism remains unclear. The role vascular endothelial growth factor-B (VEGF-B) little known. In present study, we aimed investigate whether Mel alleviated via regulation VEGF-B explored its mechanisms. Methods results We found that significantly cardiac...
Background: Maslinic acid (MA), a pentacyclic triterpenoid compound derived from leaves and fruits of Olea europaea, bears multi-pharmacological properties. Our previous studies found that MA exerted cardioprotective effect by modulating oxidative stress, inflammation, apoptosis during myocardial ischemia-reperfusion injury (MIRI). Nevertheless, data regarding the anti-ferroptosis effects on MI/RI remains unidentified Aim Study: This study aimed to explore ferroptosis induced MI/RI, with...
Background Frailty is increasingly recognized as a critical factor in the risk of chronic kidney disease (CKD), and it also condition that can undergo transitions. However, relationship between frailty transitions CKD aging populations remains underexplored. This study aims to investigate association middle-aged older adults using data from China Health Retirement Longitudinal Study.
Abstract Background Cardiac hypertrophy, a leading cause of heart failure, threatens global public health. Deubiquitinating enzymes (DUBs) are critical in cardiac pathophysiology by regulating protein stability, function, and degradation. Here, we investigated the role mechanism ovarian tumor domain-containing 7B (OTUD7B) hypertrophy modulating fatty acid metabolism. Methods Mice subjected to transverse aortic constriction (TAC) cardiomyocytes treated with phenylephrine (PE) were used...
Chronic noncommunicable diseases (NCDS) are often characterized by gradual onset and slow progression, but the difficulty in early prediction remains a substantial health challenge worldwide. This study aims to explore interconnectedness of disease occurrence through multi-omics studies validate it large-scale electronic records. In response, research examined data from 160 sub-healthy individuals at high altitude then deep learning model called Omicsformer is developed for detailed analysis...
The neutrophil-to-lymphocyte (N/L) ratio has been associated with poor outcomes in patients cardiovascular diseases, but it not studied elderly chronic heart failure (CHF).In this study, we analyzed 1355 admitted CHF. A multivariate logistic regression model was used to assess the independent association of N/L kidney disease (CKD). were then divided into tertiles according ratios. We Cox analysis between and subsequent major events (MCE), including cardiac death rehospitalization for...
The aim of the present study was to examine role eIF2α in cardiomyocyte apoptosis and evaluate cardioprotective salubrinal a rat myocardial infarction (MI) model. Rat left anterior descending coronary arteries were ligated classical proteins involved endoplasmic reticulum stress (ERS)‑induced apoptotic pathway analyzed using quantitative polymerase chain reaction western blot analysis. Salubrinal administered rats infarct size evaluated by specific staining method. Compared with sham surgery...
Endoplasmic reticulum (ER) stress results from imbalances in unfolded/misfolded proteins, contributing to a wide variety of human diseases. To better understand the mechanisms involved cellular response ER cardiomyocytes, we previously conducted genome-wide screening an vitro model rat which highlighted amino acid transporter heavy chain, member 2 (SLC3A2) as important factor stress. In present study, characterized role SLC3A2 during unfolded protein (UPR), one primary pathways activated...
The neutrophil-to-lymphocyte (N/L) ratio has been associated with poor prognosis in patients heart failure, but it not compared N-terminal pro-brain natriuretic peptide (NT-proBNP) elderly chronic failure (CHF). We sought to make this comparison.A total of 1355 CHF were analyzed. A multivariate logistic regression model was used analyze the variables atrial fibrillation (AF). Cox analysis assess multivariable relationship between N/L ratio, NT-proBNP level, and subsequent major...
Abstract: Pulmonary arterial hypertension (PAH) is a progressive and malignant disease characterized by pulmonary small arteries right ventricle (RV) remodeling that can lead to severe RV dysfunction death. The current therapeutic targets for dysfunction, which strongly linked mortality, are far from adequate. Therefore, we investigated the effect of ursolic acid (UA), pentacyclic triterpenoid carboxylic acid, on PAH-induced its underlying mechanism. We established PAH model injecting...
Chronic mountain sickness (CMS) is a high altitude complication with rates of morbidity and mortality. CMS characterized by high-altitude polycythemia (HAPC) pulmonary hypertension (HAPH). In this study, macitentan, dual endothelin receptor antagonist, was used to treat CMS, the induced metabolomics changes were studied. in rats hypobaric hypoxia chamber (simulating 5500 m plateau) for 4 weeks. Macitentan administered third fourth weeks (30 mg·kg-1·day-1). At end follow-up period, we...
The serine/threonine protein phosphatase PP1 mediates the dephosphorylation of phosphorylated eukaryotic translation initiation factor 2 subunit α (p-eIF2α), which is a central regulator synthesis. In present study, we examined protective effects PP1-12 (an inhibitor PP1) against tunicamycin (TM)-induced apoptosis in cultured cardiomyocytes vitro, as well an vivo model ischemia/reperfusion (I/R) injury rat hearts. Neonatal from ventricles hearts 1-day-old Wistar rats were exposed to various...
Abstract Purpose Doxorubicin is an important cancer chemotherapeutic agent with severe cardiotoxic effects that eventually lead to dilated cardiomyopathy (DCM). Calsyntenin-1(CLSTN1) plays a critical role in the nervous system, but its relevance cardiovascular diseases unknown. We investigated significance of CLSTN1 doxorubicin-induced DCM. Methods expression DCM rats and H9c2 cells was determined using western blotting. To further explore functions CLSTN1, cardiac-specific overexpression...
Comprehensive analyses of multi-omics data may provide insights into interactions between different biological layers concerning distinct clinical features. We integrated on the gut microbiota, blood parameters and urine metabolites treatment-naive individuals presenting a wide range metabolic disease phenotypes to delineate clinically meaningful associations. Trans-omics correlation networks revealed that candidate microbial biomarkers metabolite feature were covaried with phenotypes....
Activating transcription factor 6 (ATF6) is a transmembrane protein that consists of cytoplasmic domain and an endoplasmic reticulum (ER) luminal domain. As unfolded levels arise in the ER, ER ATF6 moves to nucleus, where it activates range genes, including those involved apoptosis. only becomes functional once has moved compounds inhibit its re-localization are therapeutic interest. The aim present study was rapidly accurately identify such using novel image‑based, high‑content screening...
Growth-differentiation factor-15 (GDF-15) is a promising prognostic biomarker in patients with chronic heart failure (CHF). Comparatively little known about the value of repeated measurement GDF-15 CHF Chinese Han population. This study sought to identify clinical post-myocardial infarction CHF.In total, 232 consecutive were enrolled prospectively from January 2014 June 2016.The plasma concentration was determined on admission and over 12 months. Patients followed up for all-cause death...
Inflammation is an important element of the pathophysiological process heart failure (HF) and correlated with subtypes HF. The association between multiple biomarkers inflammation HF in Chinese subjects remains unclear. This study aimed to compare differences among patients different who have been identified date.We included 413 consecutive HF, including 262 preserved ejection fraction (HFpEF), 55 middle-ranged (HFmrEF) 96 reduced (HFrEF). Ten were analyzed compared according subtypes. One...
Ascent to high altitude feels uncomfortable in part because of a decreased partial pressure oxygen due the decrease barometric pressure. The molecular mechanisms causing injury liver tissue after exposure hypoxic environment are widely unknown. must physiologically and metabolically change improve tolerance altitude-induced hypoxia. Since is largest metabolic organ regulates many physiological processes, it plays an important adaptation. cellular response hypoxia results changes gene...
High-altitude pulmonary hypertension (HAPH) is a complication arising from an inability to acclimatize high altitude and associated with morbidity mortality. We aimed analyze the effects of macitentan, selexipag, riociguat, reoxygenation on HAPH, screen possible targets these treatments for future drug screening. Rats were subjected hypobaric hypoxia 35 days induce treated vehicle or reoxygenation, 21 35. Selexipag, prevented increase in mean artery pressure hypoxia-induced right ventricular...
Liu, Chunlei, Xu Chen, Ge Guo, Xiang Xu, Xin Li, Qingxia Wei, Yanying Shen, Hanlu Jianxiu Hao, Ya Ping Tian, and Kunlun He. Effects of intermittent normoxia on chronic hypoxic pulmonary hypertension right ventricular hypertrophy in rats. High Alt Med Biol. 22: 184–192, 2021. Background: Individuals with chronically low arterial oxygen tension owing to high altitude develop elevated rates (PH) (RV) hypertrophy. However, the effects frequency duration normoxic exposure PH RV have not been...