A5070412819- Acute Kidney Injury Research
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Renal and Vascular Pathologies
- Radiation Dose and Imaging
- Cardiovascular Health and Disease Prevention
- Genomics, phytochemicals, and oxidative stress
- Cardiac Imaging and Diagnostics
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Dementia and Cognitive Impairment Research
- Coronary Interventions and Diagnostics
- Hormonal Regulation and Hypertension
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Laser-induced spectroscopy and plasma
- Gout, Hyperuricemia, Uric Acid
- Sirtuins and Resveratrol in Medicine
- MicroRNA in disease regulation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Fibrosis and Remodeling
- Pancreatitis Pathology and Treatment
- Vascular Procedures and Complications
- Real-time simulation and control systems
- Dysphagia Assessment and Management
Tianjin Medical University
2014-2025
Tianjin First Center Hospital
2014-2025
Nankai University
2022-2025
Dalian Municipal Central Hospital
2021
Tongji University
2021
Tongji Hospital
2021
China Academy of Space Technology
2019
China Huadian Corporation (China)
2019
Tianjin Central Hospital of Gynecology Obstetrics
2015
The First Affiliated Hospital, Sun Yat-sen University
2012
Previous trials of renal denervation (RDN) have been designed to investigate reduction blood pressure (BP) as the primary efficacy endpoint using non-selective RDN without intraoperatively verified success. It is an unmet clinical need map nerves, selectively denervate sympathetic provide readouts for interventionalists and avoid futile RDN. We aimed examine safety nerve mapping/selective (msRDN) in patients with uncontrolled hypertension (HTN) determine whether antihypertensive drug burden...
Background: Maslinic acid (MA), a pentacyclic triterpenoid compound derived from leaves and fruits of Olea europaea, bears multi-pharmacological properties. Our previous studies found that MA exerted cardioprotective effect by modulating oxidative stress, inflammation, apoptosis during myocardial ischemia-reperfusion injury (MIRI). Nevertheless, data regarding the anti-ferroptosis effects on MI/RI remains unidentified Aim Study: This study aimed to explore ferroptosis induced MI/RI, with...
Sodium-glucose transport protein 2 inhibitors (SGLT2i) have been widely used to treat patients with type diabetes mellitus (T2DM) and demonstrated protective effects against certain cardiovascular diseases. However, no clinical research has conducted explore the relationship between SGLT2i risk of aortic aneurysm (AA). We extracted analyzed data 4964 T2DM from First Affiliated Hospital Zhengzhou University during July 2017 January 2023. Multivariate Cox models, interaction analysis...
Background Frailty is increasingly recognized as a critical factor in the risk of chronic kidney disease (CKD), and it also condition that can undergo transitions. However, relationship between frailty transitions CKD aging populations remains underexplored. This study aims to investigate association middle-aged older adults using data from China Health Retirement Longitudinal Study.
Abstract Background Cardiac hypertrophy, a leading cause of heart failure, threatens global public health. Deubiquitinating enzymes (DUBs) are critical in cardiac pathophysiology by regulating protein stability, function, and degradation. Here, we investigated the role mechanism ovarian tumor domain-containing 7B (OTUD7B) hypertrophy modulating fatty acid metabolism. Methods Mice subjected to transverse aortic constriction (TAC) cardiomyocytes treated with phenylephrine (PE) were used...
Maslinic acid (MA) is a pentacyclic triterpene obtained from the peel of olives that exhibits anti-inflammatory and antioxidant properties in several conditions. Our previous study revealed MA exerted cardioprotective effect by repressing inflammation apoptosis during myocardial ischemia-reperfusion injury (MIRI). However, data regarding antioxidative effects on MIRI remains limited. This aims to elucidate roles underlying mechanisms MIRI. The left anterior descending coronary artery rats...
We investigated the preventive effect of nicorandil on contrast-induced nephropathy (CIN) in patients with moderate renal insufficiency undergoing percutaneous coronary intervention (PCI). A total 250 a creatinine clearance (crCl) ≤60 mL/min PCI were randomly assigned to either group (nicorandil 10 mg 3 times/d and hydration; n = 125) or control (hydration only; 125). The first end point was incidence CIN defined as an increase serum (Scr) levels by ≥0.5 mg/dL ≥25% within 72 hours after...
Abstract Background Evidence has shown that serum uric acid (UA) is associated with cognitive function, but this finding remains debatable. Serum UA commonly elevated in patients chronic heart failure (CHF), especially men. However, the relationship between and function CHF populations stratified by sex are unclear. We aimed to examine whether was independently after controlling for demographic, medical psychological variables there a difference association among male female patients....
This study aims to assess clinical outcomes following switching from originator generic amlodipine. population-based, matched, cohort included users of amlodipine using claims data during 2018-2020 a health system in Tianjin, China, which usage was promoted by drug procurement policy, the national volume-based procurement. Non-switchers refer those remained on after while pure-switchers were who switched and continued amlodipine, back-switchers but then back originator. Propensity score...
Background and AimsPrior studies have established the correlation between oxidative balance score (OBS) hypertension (HTN).While association OBS resistant (RHT) as well arterial stiffness among individuals with remains undisclosed. Methods ResultsIn this study, total of 15910 adults diagnosed were enrolled from NHANES 2001-2018.OBS was calculated categorized into quartiles.Weighted regression model, stratified analyses restricted cubic spine (RCS) employed to evaluate RHT, major adverse...
Hypertension constitutes a critical risk factor for cardio-cerebrovascular disease. Despite the effectiveness of lifestyle adjustments and medications in blood pressure (BP) management, hypertension control rates remain inadequate. Percutaneous renal denervation (RDN) has emerged as forward-looking evidence-supported interventional modality improvement BP regulation enhancement control. Comprehensive evidence from randomized, sham-controlled clinical trials supports sustained efficacy...
Established evidences have demonstrated that hypertension was associated with the cognitive impairment. But associations between duration of exposure and performance are still inconclusive.
Abstract Background Previous studies indicated that metabolic heterogeneity of obesity would affect the risk cardiovascular disease (CVD). However, alterations in CVD associated with transitions between various health statuses influenced by status remain unclear. Methods We utilized data from China Health and Retirement Longitudinal Study (CHARLS), a longitudinal cohort study involving Chinese residents aged 45 years older. Baseline were collected 2011–2012, follow‐up surveys conducted up to...
We investigated the preventive effect of alprostadil on contrast-induced nephropathy (CIN) in patients with renal insufficiency undergoing percutaneous coronary intervention (PCI). A total 300 creatinine clearance (crCl) ≤60 mL/min PCI were randomly assigned to or a control group. The primary end point was incidence CIN defined as an increase serum (Scr) levels by ≥0.5 mg/dL or≥ 25% after administration contrast media within 72 hours. secondary points (1) changes Scr and crCl hours (2) major...
The role of alprostadil on the prevention contrast-induced nephropathy (CIN) still remains controversial. purpose this study was to examine effects short-term incidence CIN in patients undergoing elective percutaneous coronary intervention (PCI).A total 480 with heart disease PCI were enrolled our and randomly assigned two groups. control group (n = 240) given only hydration therapy received intravenous administration 20 ug/day (diluted 100 ml normal saline) from 0.5∼1 hr before 3 days after...
Abstract Background Superior mesenteric artery embolism (SMAE) is a rare cause of acute abdomen, and the fatality rate extremely high if it not diagnosed treated in time. Due to lack knowledge experience nonspecialist physicians, easy misdiagnose. Radiofrequency ablation (RFA) has become first-line treatment strategy for atrial fibrillation (AF). Thromboembolic events are some major complications after RFA, whereas SMAE rarely reported. Case presentation A 70 year-old woman with paroxysmal...
Abstract Objective: This study was performed to explore the effects of probucol on contrast-induced acute kidney injury (CIAKI) in patients with coronary heart disease undergoing percutaneous intervention (PCI). Methods: In total, 220 PCI were randomly assigned either control group (hydration from 12 hours before after contrast administration; n = 110) or plus 500 mg twice daily 1 day and 3 days operation; 110). The primary endpoint occurrence serum creatinine (Scr)-based CIAKI, defined as...
The primary site of infection in COVID-19 exhibit is the respiratory system, but multiple organ systems could be affected. virus directly invade cardiomyocytes. Alternatively, cytokine storm lead to myocardial injury. More importantly, management existing cardiovascular diseases must re-examined due to, for example, interaction between antiviral agents and with a wide variety pharmacological agents. Branch Cardiovascular Physicians Chinese Medical Doctor Association organized panel experts...
<title>Abstract</title> <bold>Background</bold> Established evidences have demonstrated that hypertension was associated with the cognitive impairment. But associations between duration of exposure and performance are still inconclusive. <bold>Objectives</bold> The objective this study to assess association diagnosis in older adults by National Health Nutrition Examination Survey (2011–2014). <bold>Methods</bold> To evaluate relationship performance, we conducted logistic regression...
In this paper, we describe the evolution of Toxic Chemical Substances Control Act (TCSCA) regulated by Taiwan Environmental Protection Administration during past two decades. The TCSCA was originally drafted for management utilization and operation toxic chemical substances from cradle to grave. Following 921 earthquake in central 1999, newly issued Disaster Prevention Mitigation further required that risk disaster mitigation all listed chemicals must also be TCSCA. Since then, significant...
Caused by SARS-CoV-2, COVID-19 has become a severe threaten to society and human health, its epidemic control emerges as long-term issue. A sustainable environmental transmission risk (SEERC) in urban area is urgently needed. This work aims conduct new investigation on the of SARS-COV-2 virus/hazardous material through various medias, routes regions entirely for guiding SEERC. Specifically, 5 28 (totally 140 scenarios) are considered. For perspective, evaluation conducted quantification...