A5101981706- MicroRNA in disease regulation
- Bone health and osteoporosis research
- Medical Imaging and Analysis
- Cancer Cells and Metastasis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- Intraocular Surgery and Lenses
- Drug Transport and Resistance Mechanisms
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Fibroblast Growth Factor Research
- Wnt/β-catenin signaling in development and cancer
- Scoliosis diagnosis and treatment
- Parasites and Host Interactions
- Protein Degradation and Inhibitors
- Estrogen and related hormone effects
- Endoplasmic Reticulum Stress and Disease
- Liver physiology and pathology
- Coronary Interventions and Diagnostics
- Cannabis and Cannabinoid Research
- Drug-Induced Hepatotoxicity and Protection
- Cancer-related Molecular Pathways
- Pancreatic and Hepatic Oncology Research
Tianjin Medical University General Hospital
2025
Chinese PLA General Hospital
2023-2024
Sun Yat-sen University
2012-2024
Guangzhou Medical University
2024
China Atomic Energy Authority
2021-2024
First Affiliated Hospital of Zhengzhou University
2024
Sun Yat-sen Memorial Hospital
2016-2022
Third Affiliated Hospital of Sun Yat-sen University
2019
Massachusetts General Hospital
2018
Harvard University
2018
Cisplatin is an anticancer drug that has enjoyed remarkable success against testicular tumors, but dose limiting side-effects have limited its application a broader range of cancers. Previous studies shown high-mobility group (HMG) domain proteins such as HMG1 sensitize cells to cisplatin by shielding major DNA adducts from nucleotide excision repair. Estrogen treatment increases mRNA levels in breast cancer MCF-7 cells. Herein, we describe human having steroid hormone receptors with the...
Gastric cancer (GC) is a common in Asia and currently lacks targeted therapy approach. Mesothelin (MSLN) has been reported to be expressed GC tissue could by chimeric antigen receptor (CAR) T cells. targeting CAR-T mesothelioma, lung cancer, breast pancreas cancer. However, the feasibility of using anti-MSLN CAR cells treat remains studied. We verified MSLN expression primary human tissues cell lines then redirected with containing scFv (single-chain variable fragment), CD3ζ, CD28, DAP10...
Bullous pemphigoid (BP) is the most common autoimmune blistering disease, which primarily affects elderly. However, relationship between BP and malignancy remains controversial in traditional observational studies. The aim of this study, included only European populations, was to assess potential causative link 13 types malignant tumors a two-sample Mendelian randomization (MR) study. not associated with an increased risk developing tumors. This study did find causal further research...
The biological functions of growth factor, such as granulins, have been explored in parasites, and we elucidated that Clonorchis sinensis granulin (CsGRN) promoted the metastasis hepatocellular carcinoma our previous study. However, it is still unclear for malignant transformation role CsGRN normal human hepatocytes. In this study, by transfecting pEGFP-C1-CsGRN eukaryotic expression plasmid, a cell line with stable overexpression hepatocyte (LO2-GRN cells) was constructed. effects on...
Abstract Doxorubicin (Dox) is the standard treatment approach for osteosarcoma (OS), while acquired drug resistance seriously attenuates its efficiency. The present study aimed to investigate potential roles of metabolic reprogramming and related regulatory mechanism in Dox-resistant OS cells. results showed that ATP levels, lactate generation, glucose consumption oxygen rate were significantly increased cells compared with parental Furthermore, revealed expression estrogen-related receptor...
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects > 25% of the global population, potentially leading to severe hepatic and extrahepatic complications, including metabolic steatohepatitis. Given that pathophysiology MASLD is incompletely understood, identifying therapeutic targets optimizing treatment strategies are crucial for addressing this condition. Mendelian randomization (MR) analysis was conducted using two genome-wide association study datasets: a European...
Osteosarcoma patients often exhibit pulmonary metastasis, which results in high patient mortality. Understanding the mechanisms of advanced metastasis osteosarcoma cell is important for targeted treatment and drug development. Our present study revealed that transforming growth factor-β (TGF-β) can significantly promote vitro migration invasion human MG-63 HOS cells. The loss epithelial characteristics E-cadherin (E-Cad) up regulation mesenchymal markers Vimentin (Vim) suggested TGF-β...
Abstract Chemotherapy resistance is one of the major challenges for treatment osteosarcoma ( OS ). The potential roles oestrogenic signals in chemoresistance cells were investigated. As compare to parental cells, doxorubicin and cisplatin CDDP ) resistant had greater levels oestrogen‐related receptors alpha ERR α). Targeted inhibition α by its specific si RNA s or inverse agonist XCT ‐790 can restore sensitivity chemotherapy. This might be due that si‐ decrease expression P‐glycoprotein...
Sef (similar expression to fgf), also know as IL17RD, is a transmembrane protein shown inhibit fibroblast growth factor signaling in developmental and cancer contexts; however, its role tumor suppressor remains be fully elucidated. Here, we show that regulates epithelial-mesenchymal transition (EMT) breast cell lines. was highest the normal epithelial line MCF10A, intermediate MCF-7 cells lowest MDA-MB-231 cells. Knockdown of increased genes associated with EMT, promoted migration, invasion,...
Clonorchis sinensis granulin (CsGRN), a component of the excretory/secretory products this species, is multifunctional growth factor that can promote metastasis cholangiocarcinoma cells. However, effect CsGRN on human intrahepatic biliary epithelial cells (HIBECs) unclear. Here, we investigated malignant transformation HIBECs and its possible underlying mechanism.The phenotypes after treatment were estimated by EdU-488 incorporation assay, colony formation wound-healing Transwell assay...
Objective As osteoporosis progresses, the primary compressive trabeculae (PCT) in proximal femur remains preserved and is deemed principal load‐bearing structure that links femoral head with neck. This study aims to elucidate distribution patterns of PCT within elderly population, assess its implications for development optimization internal fixation devices used hip fracture surgeries. Methods a retrospective cohort conducted from March 2022 April 2023. A total 125 patients who underwent...
The NF-κB signalling pathway has been reported to be related liver fibrosis, and we investigated whether the is involved in fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis (CssPLA2). Furthermore, expression receptor CssPLA2 on cell surface hepatic stellate cells (HSCs) may greatly contribute fibrosis.CssPLA2 was administered BALB/c mice abdominal injection. levels markers activation mouse tissue were measured quantitative RT-PCR, ELISA western blot. Additionally, HSCs...
The latest perspective indicates that apoptotic dysregulation is an important mechanism in male infertility induced by varicocele. To elucidate the molecular of apoptosis caused varicocele, we used proteomics (2D-MALDI-TOF MS) to identify altered proteins testes experimental varicocele rats compared with control. Here, 21 significantly different protein spots were detected technology. 14-3-3 epsilon (14-3-3ε) was our subsequent research target because its function apoptosis. expression...
Clonorchis sinensis infection is an important risk factor for cholangiocarcinoma (CCA). It has been reported that extracellular vesicles (EVs) are involved in the parasite-host interaction, and EVs of C . ( Cs EVs) can contribute to biliary injuries inflammation. However, uncertainty surrounds function progression CCA. In this study, differential ultracentrifugation was used separate from culture supernatant adult worms, they were then identified by transmission electron microscopy,...
To explore the technical aspects of accuracy cervical pedicle screw placement with O-arm guidance.The clinical data 21 patients who underwent fixation by real-time guidance from December 2015 to January 2020 were analyzed retrospectively. There 15 males and 6 females, aged 29 76 years old an average (45.3±11.5) years. The postoperative CT scan was utilized evaluate classified according Gertzbein Robbins classification.A total 132 screws implanted in patients, 116 at C3-C6 16 C1 C2. According...
Objective To evaluate the application of ultrasound biomicroscopy (UBM) in diagnose slight lens dislocation.Methods Seventy-three patients with ocular contusion and clinical suspicion dislocation were performed UBM direct examination indirect by two technicians for detecting rupture o'clock position suspensory ligament lens.The time required was calculated.Results Among 73 cases dislocation,49 could cooperate examination.The completion rate 67.35％.All 100％.The difference statistical...
Objective To evaluate the therapeutic effect of posterior chamber foldable intraocular lens (IOL) suture fixation. Methods Posterior capsular rupture cases with small incision cataract extraction surgery were randomly divided into two groups: single-piece IOL fixation group (the control group) and experimental group). The included 11 ( eyes) 12 eyes). Postoperative follow-up observations visual acuity, pressure, astigmatism change deviation. Results uncorrected acuity improved in all cases....