A5101758583- melanin and skin pigmentation
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Advanced Proteomics Techniques and Applications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune Bullous Skin Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Ovarian cancer diagnosis and treatment
- Scoliosis diagnosis and treatment
- Plant Stress Responses and Tolerance
- T-cell and B-cell Immunology
- Gut microbiota and health
- Skin and Cellular Biology Research
- Insect Resistance and Genetics
- Eosinophilic Disorders and Syndromes
- Molecular Biology Techniques and Applications
- Medical Imaging and Analysis
- Crop Yield and Soil Fertility
- Cholesterol and Lipid Metabolism
- Platelet Disorders and Treatments
- Plant Pathogens and Fungal Diseases
- Monoclonal and Polyclonal Antibodies Research
- Endometriosis Research and Treatment
- Retinoids in leukemia and cellular processes
- Metabolomics and Mass Spectrometry Studies
First Affiliated Hospital of Zhengzhou University
2024-2025
Chongqing Public Health Medical Center
2025
Chongqing Medical University
2025
Sun Yat-sen Memorial Hospital
2025
Sun Yat-sen University
2025
Affiliated Hospital of Youjiang Medical University for Nationalities
2024
Jinan University
2024
University of Hohenheim
2020-2024
Institute of Computing Technology
2024
Chinese Academy of Sciences
2024
Bullous pemphigoid (BP) is the most common autoimmune blistering disease, which primarily affects elderly. However, relationship between BP and malignancy remains controversial in traditional observational studies. The aim of this study, included only European populations, was to assess potential causative link 13 types malignant tumors a two-sample Mendelian randomization (MR) study. not associated with an increased risk developing tumors. This study did find causal further research...
Vitiligo is a complex autoimmune disease characterized by the loss of melanocytes, leading to skin depigmentation. Despite advances in understanding its genetic and molecular basis, precise mechanisms driving vitiligo remain elusive. Integrating multiple layers omics data can provide comprehensive view pathogenesis identify potential therapeutic targets. The study aims delineate using an integrative multiomics strategy. We focus on exploring regulatory influence JAK/STAT pathway Cathepsin S,...
Endometriosis (EM) is a chronic disease severely impacting reproductive health, with its exact cause still unclear. In-depth understanding of the etiology and pathogenesis EM from perspective genetics exploring individualized treatment strategies can improve health quality life patients. In this study, whole blood cis- expression quantitative trait loci (eQTL) data were used as exposure data, FinnGen database EM1-2 EM3-4 outcomes. Summary-data-based mendelian randomization (SMR) methods to...
This report details a rare case of paraneoplastic pemphigus (PNP) associated with pheochromocytoma. The patient presented prominent dermatological manifestations, including erythema, vesicles, and erosions. During hospitalization, diagnostic imaging revealed retroperitoneal mass, which was subsequently surgically removed. A comprehensive workup, CT, MRI, histopathological analysis, direct immunofluorescence examination, conducted. Postoperative management combined pharmacological...
Drought has become a major stress for agricultural productivity in temperate regions, such as central Europe. Thus, information on how crop plants respond to drought is important develop tolerant hybrids and ensure yield stability. Posttranscriptional regulation through changed protein abundances an mechanism of short-term response events that not yet been widely exploited breeding strategies. Here, we investigated the repeated exposure sensitive maize hybrid order understand general...
Comparative study.To compare manual and deep learning-based automated measurement of Cobb angle in adolescent idiopathic scoliosis.We proposed a fully framework to measure the AIS patients. Whole-spine images 500 individuals were collected. 200 digital radiographic (DR) labeled manually as training set, remaining 300 used validate by mean absolute error (MAE), Pearson or spearman correlation coefficients, intra/interclass coefficients (ICCs). The relationship between accuracy vertebral...
Introduction: Vitiligo, a common autoimmune acquired pigmentary skin disorder, poses challenges due to its unclear pathogenesis. Evidence suggests inflammation and metabolism’s pivotal roles in onset progression. This study aims elucidate the causal relationships between vitiligo inflammatory proteins, immune cells, metabolites, exploring bidirectional associations potential drug targets. Methods: Mendelian Randomization (MR) analysis encompassed 4,907 plasma 91 731 cell features, 1400...
Thyroid nodule is a common thyroid disease, but the study of its pathology and pathogenesis still limited. As non-invasive diagnostic method, medical image examination great value to pathological correlation nodules. The purpose this was investigate expression eosinophils in between analyzed reports group patients with nodules examined by images performed corresponding imaging scans or examinations. data processed, including reconstruction, transmission other steps, generate that can be...
Proteomics and phosphoproteomics are robust tools to analyze dynamics of post-transcriptional processes during growth development. A variety experimental methods workflows have been published, but most them were developed for model plants not adapted high-throughput platforms. Here, we describe an workflow proteome phosphoproteome studies tailored cereal crop tissues. The consists two parallel parts that suitable analyzing protein/phosphoprotein from total proteins the microsomal membrane...
Introduction: Vitiligo is an autoimmune disease characterized by the loss of skin pigmentation. This study aims to explore genetic associations between vitiligo and 21 diseases using Mendelian randomization (MR) analysis, with a focus on identifying potential risk protective factors. Methods: We performed univariable multivariable analyses assess causal vitiligo. Confounding factors, including smoking, alcohol consumption, Body Mass Index (BMI), were integrated into analysis. Strongly...
Strains from the
<title>Abstract</title> Background: Vitiligo is a complex autoimmune disease characterized by the loss of melanocytes, leading to skin depigmentation. Despite advances in understanding its genetic and molecular basis, precise mechanisms driving vitiligo remain elusive. Integrating multiple layers omics data can provide comprehensive view pathogenesis identify potential therapeutic targets. Methods: We first performed genome-wide association study (GWAS) meta-analysis druggability assessment...
Due to limited treatment options, cutaneous warts caused by human papillomavirus (HPV) remain a significant clinical challenge. Furthermore, the genetic susceptibility and molecular basis of viral are not yet fully understood.