A5044788727- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Neonatal Respiratory Health Research
- Estrogen and related hormone effects
- Respiratory Support and Mechanisms
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects of Natural Compounds
- Metabolomics and Mass Spectrometry Studies
- Phytochemistry and Biological Activities
- Plant-based Medicinal Research
- Peroxisome Proliferator-Activated Receptors
- Phytoestrogen effects and research
- Neuroscience of respiration and sleep
- Cholesterol and Lipid Metabolism
- Traditional Chinese Medicine Studies
- Cardiac Ischemia and Reperfusion
- Nitric Oxide and Endothelin Effects
- Sleep and Wakefulness Research
- Ginseng Biological Effects and Applications
- Pulmonary Hypertension Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Angiogenesis and VEGF in Cancer
- Autophagy in Disease and Therapy
Tianjin University of Traditional Chinese Medicine
2016-2025
Capital Medical University
2012-2025
Anhui Medical University
2025
Ministry of Agriculture and Rural Affairs
2025
Anhui Agricultural University
2025
Hubei University
2009-2024
Beijing Shijitan Hospital
2024
Tianjin haihe hospital
2023-2024
Dalian National Laboratory for Clean Energy
2024
Dalian Institute of Chemical Physics
2024
Blood vessels express estrogen receptors, but their role in cardiovascular physiology is not well understood. We show that vascular smooth muscle cells and blood from receptor beta (ERbeta)-deficient mice exhibit multiple functional abnormalities. In wild-type mouse vessels, attenuates vasoconstriction by an ERbeta-mediated increase inducible nitric oxide synthase expression. contrast, augments ERbeta-deficient mice. Vascular isolated abnormalities of ion channel function. Furthermore,...
Tamoxifen inhibits estrogen receptor (ER)-positive breast cancer growth while CD36 potentiates metastasis. The effects of on proliferation/migration cells and tamoxifen-inhibited ER-positive cell are unknown. In this study, we correlated the mortality patients to tumor expression levels. We also found was higher in ER-rich (MCF-7>T-47D~ZR-75-30) than ER-negative (MDA-MB-231) cells. siRNA decreased viability migration MCF-7 MDA-MB-231 with more potent Inversely, high expressing enhanced...
Abstract Tissue‐resident cardiac macrophage subsets mediate tissue inflammation and repair after acute myocardial infarction (AMI). CC chemokine receptor 2 (CCR2)‐expressing macrophages have phenotypical similarities to M1‐polarized macrophages, are pro‐inflammatory, recruit CCR2 + circulating monocytes infarcted myocardium. Small extracellular vesicles (sEV) from ̶ which phenotypically resemble M2‐polarized promote anti‐inflammatory activity repair. Here, the authors harvested M2...
Protein misfolding, accumulation, and aggregation characterize many aging-related diseases. aggregates do not accumulate in unstressed cells primarily because of the existence competent cellular "quality control" machinery. The endoplasmic reticulum (ER) is a major part this quality control system. Accumulation misfolded proteins ER causes stress activates signaling pathway called unfolded protein response (UPR). UPR limits load by upregulating chaperones such as Ig binding...
Nitric oxide (NO) is a potent vasodilator and inhibitor of platelet activation. NO stimulates production cGMP activates cGMP-dependent protein kinase (G kinase), which by an unknown mechanism leads to inhibition Gα q -phospholipase C-inositol 1,4,5-triphosphate signaling intracellular calcium mobilization for several important agonists, including thromboxane A 2 (TXA ). To explore the NO, activation TXA receptors in presence was studied. The nonhydrolyzable analog 8-bromo-cyclic GMP...
The nucleus accumbens (NAcc) can be subdivided into `core' and `shell' based on anatomical connections histochemical markers. Previous studies have demonstrated dopamine-β-hydroxylase immunoreactive (DBH-ir) fibers in the NAcc shell, but source of these noradrenergic (NE) afferents has not been determined. Therefore, we investigated detail anatomy NE to this subregion. Dual immunohistochemistry for DBH substance P numerous DBH-ir caudal shell. Neurons projecting were identified with...
Hyperactivity of brain norepinephrine (NE) systems has long been implicated in mechanisms opiate withdrawal (OW). However, little is known about where elevated NE may act to promote OW. Here we report that the bed nucleus stria terminalis (BNST), densest target brain, critical for actions (1) Many BNST neurons become Fos+ after Pretreatment with beta antagonist, propranolol, markedly reduces OW symptoms and number cells BNST. (2) Numerous tractus solitarius (A2 neurons) A1 cell group are...
Abstract Introduction High‐flow nasal cannula therapy (HFNC) has been shown to be more effective than continuous positive airway pressure (CPAP) in reducing intubations and ventilator days. HFNC likely provides mechanisms support respiratory efficiency beyond application of distending pressure. We reason that washout nasopharyngeal dead space impacts CO 2 removal along with oxygenation. The aim this study was demonstrate the flow dependence reduction improved oxygenation during on leak...
Recent data have indicated that estradiol can modulate the kinetics of endothelial progenitor cells (EPCs) via nitric oxide synthase (eNOS)-dependent mechanisms. We hypothesized could augment incorporation bone marrow (BM)-derived EPCs into sites ischemia-induced neovascularization, resulting in protection from ischemic injury.Myocardial infarction (MI) was induced by ligation left coronary artery ovariectomized mice receiving either 17beta-estradiol or placebo. Estradiol significant...
Cardiac hypertrophy is a common response to injury and hemodynamic stress an important harbinger of heart failure death. Herein, we identify the Kruppel-like factor 15 (KLF15) as inhibitor cardiac hypertrophy. Myocardial expression KLF15 reduced in rodent models biopsy samples from patients with pressure-overload induced by chronic valvular aortic stenosis. Overexpression neonatal rat ventricular cardiomyocytes inhibits cell size, protein synthesis hypertrophic gene expression. KLF15-null...
The presence of refractory wake impairments in many individuals with severe sleep apnea led us to hypothesize that the hypoxia/reoxygenation events permanently damage wake-active neurons. We now confirm long-term exposure adult mice results irreversible impairments. Functionality and injury were next assessed major neural groups. Hypoxia/reoxygenation for 8 weeks resulted vacuolization perikarya dendrites markedly impaired c -fos activation response enforced wakefulness both noradrenergic...
Background— Estradiol (E 2 ) modulates the kinetics of circulating endothelial progenitor cells (EPCs) and favorably affects neovascularization after ischemic injury. However, roles estrogen receptors α (ERα) β (ERβ) in EPC biology are largely unknown. Methods Results— In response to E , migration, tube formation, adhesion, estrogen-responsive element–dependent gene transcription activities were severely impaired EPCs obtained from ERα-knockout mice (ERαKO) moderately ERβKO EPCs. The number...
Modern society enables a shortening of sleep times, yet long-term consequences extended wakefulness on the brain are largely unknown. Essential for optimal alertness, locus ceruleus neurons (LCns) metabolically active that fire at increased rates across sustained wakefulness. We hypothesized is metabolic stressor to LCns and that, with wakefulness, adaptive mitochondrial responses fail injury ensues. The nicotinamide adenine dinucleotide-dependent deacetylase sirtuin type 3 (SirT3)...
This article reviews the application of human airway Calu-3 cell line as a respiratory model for studying effects gas concentrations, exposure time, biophysical stress, and biological agents on epithelial cells. cells are grown to confluence at an air-liquid interface permeable supports. To conditions treatment modalities, monolayers placed in environmental chamber, exposed specific levels oxygen or other therapeutic modalities such positive pressure medications assess effect interventions...