A5100370988- Neuroscience of respiration and sleep
- Functional Brain Connectivity Studies
- Circadian rhythm and melatonin
- Advanced Neuroimaging Techniques and Applications
- Adipose Tissue and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- Natural product bioactivities and synthesis
- Neonatal and fetal brain pathology
- Neuropeptides and Animal Physiology
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Diet and metabolism studies
- Neural and Behavioral Psychology Studies
- Autism Spectrum Disorder Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Memory and Neural Computing
- Signaling Pathways in Disease
- Bioactive natural compounds
- Ion Channels and Receptors
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Genomics, phytochemicals, and oxidative stress
- Medicinal Plant Pharmacodynamics Research
- Traditional Chinese Medicine Analysis
- Protease and Inhibitor Mechanisms
Fourth Affiliated Hospital of Guangxi Medical University
2025
HKUST Shenzhen Research Institute
2023-2024
Shenzhen Institutes of Advanced Technology
2023
Wuhan Children's Hospital
2023
Huazhong University of Science and Technology
2023
Tianjin University of Traditional Chinese Medicine
2009-2022
Johns Hopkins Medicine
2014-2019
Johns Hopkins University
2014-2019
Chinese People's Armed Police General Hospital
2014-2018
Zhejiang Provincial People's Hospital
2017
Body temperature homeostasis is critical for survival and requires precise regulation by the nervous system. The hypothalamus serves as principal thermostat that detects regulates internal temperature. We demonstrate ion channel TRPM2 [of transient receptor potential (TRP) family] a sensor in subpopulation of hypothalamic neurons. limits fever response may detect increased temperatures to prevent overheating. Furthermore, chemogenetic activation inhibition TRPM2-expressing neurons vivo...
While much work has been conducted regarding the neurogenesis response to traumatic brain injury (TBI) in rodents, it remains largely unknown whether adult human also responds TBI a similar manner. Here, we performed immunocytochemistry on 11 specimens from patients with injury, who underwent surgical intervention. We found that expression of neural stem/progenitor cell (NSC) protein markers, including DCX, TUC4, PSA-NCAM, SOX2 and NeuroD, was increased perilesional cortex after compared...
Abstract Background Microdeletion of the human chromosomal region 16p11.2 (16p11.2 $${}^{+/-}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msup> <mml:mrow/> <mml:mrow> <mml:mo>+</mml:mo> <mml:mo>/</mml:mo> <mml:mo>-</mml:mo> </mml:mrow> </mml:msup> </mml:math> ) is a prevalent genetic factor associated with autism spectrum disorder (ASD) and other neurodevelopmental disorders. However its pathogenic mechanism remains unclear, effective treatments for syndrome are lacking....
Previous studies have documented that heightened impulsivity likely contributes to the development and maintenance of alcohol use disorders. However, there is still a lack comprehensively detected brain changes associated with abnormal in addicts. This study was designed investigate alterations structure functional connectivity dependent patients.Brain structural magnetic resonance imaging data as well impulsive behavior were collected from 20 patients age- sex-matched healthy controls...
To study gene function in neural progenitors and radial glia of the retina hypothalamus, we developed a Rax-CreERT2 mouse line which tamoxifen-inducible Cre recombinase is inserted into endogenous Rax locus. By crossing with Cre-dependent Ai9 reporter line, demonstrate that tamoxifen-induced activity recapitulates mRNA expression pattern. During embryonic development, confined to retinal hypothalamic progenitor cells, as well cells posterior pituitary. At postnatal time points, selective...
Thermal homeostasis is vital for mammals and controlled by brain neurocircuits. Yet, the neural pathways responsible cold defense regulation are still unclear. Here, we found that a pathway from lateral parabrachial nucleus (LPB) to dorsomedial hypothalamus (DMH), which runs parallel canonical LPB preoptic area (POA) pathway, also crucial defense. Together, these make an equivalent cumulative contribution, forming circuit. Specifically, activation of → DMH induced strong cold-defense...
Background Developing more effective strategies to prevent relapse remains one of the major challenges treating substance dependence. Previous studies have identified brain abnormalities in abstinent alcoholics. However, whether these persistent deficits abstinence could predict early alcohol use has not been well established. This study aimed identify biomarkers vulnerability by investigating alcohol-dependent patients. Methods Brain imaging and impulsive behavior data were collected from...
Fibroblasts in the fibrotic heart exhibit a heterogeneous biological behavior. The specific subsets of fibroblasts that contribute to progressive cardiac fibrosis remain unrevealed. Our aim is identify fibroblast (FB) most significantly promote and related critical genes as biomarkers for ischemic disease. single nuclei RNA sequencing (snRNA-seq) bulk datasets used this study were obtained from Gene Expression Omnibus (GEO). activity gene sets was quantified each FB cluster using...
Abstract The aim of the present study was to ascertain neural correlates for integration visual information with control reach‐to‐grasp action in healthy human brain. Nine adult subjects (18–38 years; four females and five males) were scanned using functional magnetic resonance imaging while reaching‐to‐grasp a three‐dimensional target. Results demonstrated differential activation parietal cortices according number potential targets be taken into account before movement initiation...
Excess or deficiency of catecholamine (CA) secretion was related with several diseases. Recently, estrogen and phytoestrogens were reported to regulate the activity CA system. Bakuchiol is a phytoestrogen isolated from seeds Psoralea corylifolia L. (Leguminosae) which has been used in Traditional Chinese medicine as tonic aphrodisiac. In present study, bovine adrenal medullary cells employed investigate effects mechanisms bakuchiol on regulation secretion. Further, its anti-depressant like...
Rapidly approaching objects indicating threats can induce defensive response through activating a subcortical pathway comprising superior colliculus (SC), lateral posterior nucleus (LP), and basolateral amygdala (BLA). Abnormal has been reported in autism, impaired synaptic connections could be the underlying mechanism. Whether SC-LP-BLA processes looming stimuli abnormally autism is not clear. Here, we found that looming-evoked subgroup of valproic acid (VPA) mouse model autism. By...
Background The early diagnosis of autism in children is particularly important. However, there no obvious objective indices for the spectrum disorder (ASD), especially toddlers aged 1–3 years with language development delay (LDD). differential ASD challenging. Objective To examine differences dynamic characteristics regional neural activity and LDD, whether can be used as an imaging biomarker LDD. Methods Dynamic homogeneity (dReHo) amplitude low-frequency fluctuations (dALFF) 55 31 years,...
Spastic diplegic cerebral palsy(SDCP)is a common type of palsy (CP), which presents as group motor-impairment syndromes. Previous conventional MRI studies have reported abnormal structural changes in SDCP, such periventricular leucomalacia. However, there are roughly 27.8% SDCP patients presenting normal appearance MRI, were considered occult SDCP. In this study, sixteen with and 16 age- sex-matched healthy control subjects collected the data acquired on 3T MR system. We applied voxel-based...
For wild natural medicine, unanticipated biodiversity as species or varieties with similar morphological characteristics and sympatric distribution may co-exist in a single batch of medical materials, which affects the efficacy safety clinical medication. DNA barcoding an effective identification tool is limited by its low sample throughput nature. In this study, combining mini-barcode, metabarcoding delimitation method, novel biological sources consistency evaluation strategy was proposed,...
Abstract The hypothalamus is a central regulator of many innate behaviors essential for survival, but the molecular mechanisms controlling hypothalamic patterning and cell fate specification are poorly understood. To identify genes that control development, we have used single-cell RNA sequencing (scRNA-Seq) to profile mouse gene expression across 12 developmental time points between embryonic day 10 postnatal 45. This identified delineated clear trajectories all major types, readily...
Abstract Bilateral rapid‐rate transcranial magnetic stimulation (rTMS) of gerbil auditory cortex with a miniature coil device was used to study short‐term and long‐term effects on discrimination learning frequency‐modulated tones. We found previously that directional frequency modulation (rising vs. falling) relies processing formation its memory depends local protein synthesis. Here we show that, during training over 5 days, certain rTMS regimes contingent had differential the time course...
Summary Thermal homeostasis is vital for mammals and controlled by brain neurocircuits. Remarkable advances have been made in understanding how neurocircuits centered the hypothalamic preoptic area (POA), brain’s thermoregulation center, control warm defense, whereas mechanisms which POA regulates cold defense remain unclear. Here, we confirmed that pathway from lateral parabrachial nucleus (LPB) to POA, critical defense. Parallel this pathway, uncovered a LPB dorsomedial hypothalamus (DMH),...
Naoxintong capsule has beneficial effects for activating blood circulation, dispersing stasis and dredging collateral. It is widely used in the treatment of coronary heart disease, angina pectoris, stroke cardiovascular disease. However, pharmacodynamic basis possible mechanism its preventive are not clear. In this study, 10 male female C57BL/6 mice were used, randomly divided into control group (saline) group. Adaptively fed 7 days common conditions, given or saline 3 via intragastric...