A5066434426- Adipose Tissue and Metabolism
- Circadian rhythm and melatonin
- Neuroscience of respiration and sleep
- Neurobiology and Insect Physiology Research
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Fibroblast Growth Factor Research
- Neuropeptides and Animal Physiology
- Pancreatic function and diabetes
- Neuroendocrine regulation and behavior
- Protein Structure and Dynamics
- Treatment of Major Depression
- Regulation of Appetite and Obesity
- Neuroscience and Neuropharmacology Research
ShanghaiTech University
2020-2025
Shanghai Institutes for Biological Sciences
2020
Chinese Academy of Sciences
2020
University of Chinese Academy of Sciences
2020
Center for Excellence in Brain Science and Intelligence Technology
2020
Heat defense is crucial for survival and fitness. Transmission of thermosensory signals into hypothalamic thermoregulation centers represents a key layer regulation in heat defense. Yet, how these are transmitted the hypothalamus remains poorly understood. Here, we reveal that lateral parabrachial nucleus (LPB) glutamatergic prodynorphin cholecystokinin neuron populations progressively recruited to defend elevated body temperature. These two nonoverlapping types form circuits with downstream...
Thermal homeostasis is vital for mammals and controlled by brain neurocircuits. Yet, the neural pathways responsible cold defense regulation are still unclear. Here, we found that a pathway from lateral parabrachial nucleus (LPB) to dorsomedial hypothalamus (DMH), which runs parallel canonical LPB preoptic area (POA) pathway, also crucial defense. Together, these make an equivalent cumulative contribution, forming circuit. Specifically, activation of → DMH induced strong cold-defense...
Highlights•Cryo-EM structures of GPR3 in monomer and dimer states•TM5 mediates extensive interface•ICL3 regulates signaling•Oligomerization is linked to autoinhibition GPR3SummaryG protein-coupled receptor 3 (GPR3) a class A orphan characterized by high constitutive activity the Gs signaling pathway. has been implicated Alzheimer's disease regulation thermogenesis human adipocytes, yet molecular mechanisms underlying its self-activation potential endogenous modulators remain unclear. In this...
Summary Thermal homeostasis is vital for mammals and controlled by brain neurocircuits. Remarkable advances have been made in understanding how neurocircuits centered the hypothalamic preoptic area (POA), brain’s thermoregulation center, control warm defense, whereas mechanisms which POA regulates cold defense remain unclear. Here, we confirmed that pathway from lateral parabrachial nucleus (LPB) to POA, critical defense. Parallel this pathway, uncovered a LPB dorsomedial hypothalamus (DMH),...
ABSTRACT Heat defense is crucial for survival and fitness, its dysregulation may result in deaths due to poor management. Transmission of thermosensory signals into hypothalamic thermoregulation centers represent a key layer regulation heat defense. However, the mechanism by which these are transmitted hypothalamus remains poorly understood. Here, we reveal that glutamatergic prodynorphin cholecystokinin neuron populations lateral parabrachial (LPB) progressively recruited defend elevated...
Depression is a common affective disorder characterized by significant and persistent low mood. Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, reported to have rapid durable antidepressant effect, but the mechanisms are unclear. Protein phosphorylation post-translational modification that plays crucial role in cell signaling. Thus, we present phosphoproteomics approach investigate underlying stress-induced depression effect of ketamine mice. We analyzed phosphoprotein changes...