A5057458449- ZnO doping and properties
- Gas Sensing Nanomaterials and Sensors
- Copper-based nanomaterials and applications
- Transition Metal Oxide Nanomaterials
- Peptidase Inhibition and Analysis
- Adipokines, Inflammation, and Metabolic Diseases
- Ubiquitin and proteasome pathways
- Cervical Cancer and HPV Research
- Regulation of Appetite and Obesity
- Retinal Imaging and Analysis
- Electrospun Nanofibers in Biomedical Applications
- Ear Surgery and Otitis Media
- Advanced Photocatalysis Techniques
- Angiogenesis and VEGF in Cancer
- Biochemical Analysis and Sensing Techniques
- Nasal Surgery and Airway Studies
- Photoacoustic and Ultrasonic Imaging
- Maternal and fetal healthcare
- Nerve injury and regeneration
- Phonocardiography and Auscultation Techniques
- Antimicrobial Peptides and Activities
- Ultrasound in Clinical Applications
- Infectious Aortic and Vascular Conditions
- Chromatography in Natural Products
- Maternal Mental Health During Pregnancy and Postpartum
Xiamen University of Technology
2022-2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2008-2022
Dalian Medical University
2018-2021
Chongqing Medical University
2018-2021
Second Affiliated Hospital of Chongqing Medical University
2018-2021
Southwest Medical University
2019
Simcere Pharmaceutical (China)
2009-2010
Instytut Farmaceutyczny
2009-2010
Antibacterial hydrogels are attracting extensive attention in soft tissue repair and regeneration, including bacteria-infected-wound healing. The abuse of antibiotics leads to drug resistance. Recent developments have demonstrated that the delivery inorganic bactericidal agents can drive wound healing process; however, this approach is complicated by external light stimuli, cytotoxicity, nondegradability, sophisticated fabrication. Herein, an inherent antibacterial, bioresorbable hydrogel...
New series of dipeptidyl boronate inhibitors 20S proteasome were designed and synthesized. The comprehensive understanding the SAR was obtained by utilizing variation four substituents. From screened compounds in enzyme, novel 49 50 identified to be highly potent druglike candidates with IC(50) values 1.2 1.6 nM, respectively, which showed better activities than drug bortezomib on market. Two hematologic human tumor cell lines, HL-60 U266, significantly sensitive both nearly same potency as...
A series of novel dipeptidyl boronic acid proteasome inhibitors composed beta-amino acids were synthesized, in vitro and vivo biologically evaluated, theoretically modeled for the first time. From screened racemic compounds enzyme, 4i was most active. The IC(50) value its pure enantiomer 4q 9.6 nM, 36-fold more active than isomer 4p as marketed bortezomib inhibiting human 20S proteasome. This candidate also showed good activities with values nearly less 5 microM against several solid...
An extensive structure-activity relationship (SAR) study of 72 dipeptidyl boronic acid proteasome inhibitors constructed from β-amino acids is reported. SAR analysis revealed that bicyclic groups at the R¹ position, 3-F substituents R² and bulky aliphatic R³ position were favorable to activities. Enzymatic screening results showed compound 78, comprising all these features, was most active inhibitor against 20S human less than a 2 nM level, as marketed drug bortezomib. Cellular assays...
C1qTNF-related protein 4 (CTRP4) acts in the hypothalamus to modulate food intake diet-induced obese mice and has been shown exert an anti-inflammatory effect on macrophages. Since high-fat microglial activation hypothalamic inflammation impair leptin signaling increase intake, we aimed explore potential connection between anorexigenic of CTRP4 suppression with DIO. Using adenovirus-mediated overexpression model, investigated impact pathway mice. Furthermore, central plasma proinflammatory...
Fear of childbirth (FOC) can influence both maternal and child health. Research on FOC in China is scarce, especially rural women. This study aimed to assess pre- postpartum its predictors among Chinese
Abstract Background Human Papilloma Virus (HPV) DNA tests are highly sensitive and can triage women with mild lesions, improving the prognosis diagnosis of cervical lesions. However, additional efficient strategies should be developed to improve specificity these tests. Methods This study aimed evaluate clinical value HPV load in lesions by p16/Ki-67 testing. Histological samples were collected from 350 HR-HPV genotyping analyzed qRT-PCR. Immunohistochemical staining was used assess p16...
Abstract We developed an optical coherence tomography angiography technique by improving the speckle contrast algorithm and imaging process. This technique, which can achieve angiogenesis in vivo without increasing trauma, was used to evaluate microvasculature limb ischemia mice. Sixteen left hindlimb mice were randomly allocated into CuSO 4 saline groups. Within 7 days after treatment, ischemic damage, temperature histological staining assessed traditional methods. In addition, evaluated...
We have fabricated a hybrid membrane composed of polycaprolactone and natural polysaccharide, chitosan. The incorporation chitosan enabled heparinization the material via electrostatic interaction between heparin More importantly, since multiple cytokines exhibited binding affinity towards heparin, polycaprolactone/chitosan compound also facilitated immobilization monocyte chemoattractant protein-1, which is well-reported pro-angiogenic chemokine. Results demonstrated that heparinized with...
The quest for indium-free transparent conductive electrodes with enhanced optical band gaps and superior electrical conductivity is imperative the advancement of flexible electrochromic devices. This study presents a groundbreaking approach wherein composite ZnO films, incorporating Mg and/or B dopants through facile sol–gel spin coating method, are meticulously crafted systematically scrutinized their optoelectrical properties. Our findings reveal that doping primarily influences gap, while...
WO3 has become one of the most widely used electrochromic films due to its excellent stability and high optical modulation amplitude. However, with development commercial applications, demand for performance is constantly increasing, so it great significance improve by doping or composite design. In this experiment, WO3/Ag/WOx "Sandwich" structure were prepared DC magnetron sputtering. The surface morphology element composition analyzed SEM XPS. properties before after cycling studied...