A5100397323- Monoclonal and Polyclonal Antibodies Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury Research
- Pharmacological Effects of Natural Compounds
- Metabolomics and Mass Spectrometry Studies
- Estrogen and related hormone effects
- Dementia and Cognitive Impairment Research
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Mycobacterium research and diagnosis
- Berberine and alkaloids research
- Intensive Care Unit Cognitive Disorders
- Tuberculosis Research and Epidemiology
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Flavonoids in Medical Research
- Bacteriophages and microbial interactions
- Mitochondrial Function and Pathology
- Menopause: Health Impacts and Treatments
- Aortic Disease and Treatment Approaches
- Cholinesterase and Neurodegenerative Diseases
- Traditional Chinese Medicine Analysis
- Advanced Neuroimaging Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Thyroid Disorders and Treatments
Xijing Hospital
2023-2025
Air Force Medical University
2023-2025
Taiyuan University of Technology
2024
Shenyang Medical College
2023-2024
Agricultural Genomics Institute at Shenzhen
2024
Chinese Academy of Agricultural Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
Jiangsu Academy of Agricultural Sciences
2023
Chinese University of Hong Kong
2023
Second Affiliated Hospital of Nanjing Medical University
2022-2023
Perioperative neurocognitive disorders (PND) occur frequently after surgery, especially in aged patients. Surgery-induced neuroinflammation and blood-brain barrier (BBB) dysfunction play a crucial role the pathogenesis of PND. Interleukin-17A (IL-17A) increases surgical stress will be involved BBB dysfunction. However, effect IL-17A on function during PND remains poorly understood.Male wild-type C57BL/6J mice (15 months old) received tibial fracture surgery fixation to establish model. All...
Abstract Background Neuroinflammation, which ultimately leads to neuronal loss, is considered play a crucial role in numerous neurodegenerative diseases. The neuroinflammatory process characterized by the activation of glial cells such as microglia. Endoplasmic reticulum (ER) stress commonly associated with impairments function and cognition, but its relationship neurodegeneration still controversial. Recently, it was confirmed that nonharmful levels ER protected against experimental...
<ns4:p>The brain undergoes two aging programs: chronological and endocrinological. This is particularly evident in the female brain, which programs of associated with reproductive competency. Comprehensive understanding dynamic metabolic neuroinflammatory process can illuminate windows opportunities to promote healthy aging. Bioenergetic crisis chronic low-grade inflammation are hallmarks menopause have been implicated as a unifying factor causally connecting genetic risk factors for...
Postoperative cognitive dysfunction (POCD) is defined as new impairment (memory and impaired performance) after surgery, especially in aged patients. Sleep disturbance a common phenomenon before surgery that has been increasingly thought to affect patient recovery. However, little known about the functional impact of preoperative sleep on POCD. Here, we showed tibial fracture induced deficit production proinflammatory cytokines interleukin-6 (IL-6) IL-1 β , along with microglia astrocyte...
Abstract Decline in brain glucose metabolism is a hallmark of late-onset Alzheimer’s disease (LOAD). Comprehensive understanding the dynamic metabolic aging process can provide insights into windows opportunities to promote healthy aging. Chronological and endocrinological are associated with hypometabolism mitochondrial adaptations female brain. Using rat model recapitulating fundamental features human menopausal transition, results transcriptomic analysis revealed stage-specific shifts...
Late onset Alzheimer's disease (LOAD) is a progressive neurodegenerative with four well-established risk factors: age, APOE4 genotype, female chromosomal sex, and maternal history of AD. Each factor impacts multiple systems, making LOAD complex systems biology challenge. To investigate interactions between factors, we performed scale analyses, including metabolomics, transcriptomics, brain magnetic resonance imaging (MRI), beta-amyloid assessment, in 16 months old male mice humanized human...
Abstract Background Microglia, the principal sentinel immune cells of central nervous system (CNS), play an extensively vital role in neuroinflammation and perioperative neurocognitive disorders (PND). Histamine, a potent mediator inflammation, can both promote prevent microglia-related by activating different histamine receptors. Rat microglia express four receptors (H1R, H2R, H3R, H4R), among which 1 4 activation, whereas cellular mechanism 2 3 have not been elucidated. Therefore, we...
Hypoxia-ischemia (HI) is a major cause of brain damage in neonates. Mitochondrial dysfunction acts as hub for broad spectrum signaling events, culminating cell death triggered by HI. A neuroprotective role melatonin (MT) has been proposed, and mitophagy regulation seems to be important survival. However, the molecular mechanisms underlying MT-mediated during HI treatment are poorly defined. Nucleotide-binding oligomerization domain leucine-rich repeat-containing protein X1 (NLRX1) emerged...
Abstract Background Metastasis is the major cause of morbidity and mortality in cancer that involves multiple steps including epithelial–mesenchymal transition (EMT) process. Centrosome an organelle functions as microtubule organizing center (MTOC), centrosome abnormalities are commonly correlated with tumor aggressiveness. However, conclusive mechanisms indicating specific centrosomal proteins participated progression metastasis remain largely unknown. Methods The expression levels...
As one of the essential nutrients for plants, nitrogen (N) has a major impact on yield and quality wheat worldwide. Due to chemical fertilizer pollution, it become increasingly important improve crop by increasing N use efficiency (NUE). Therefore, understanding response mechanisms low (LN) stress is regulation NUE in wheat. In this study, LN significantly accelerated root growth, but inhibited shoot growth. Further transcriptome analysis showed that 8468 differentially expressed genes...
Background: Severe pulmonary regurgitation (PR) often occurs after treatment of tetralogy Fallot with a valve ring patch, leading to enlargement and diverse morphological characteristics the native right ventricular outflow tract (nRVOT), which increases difficulty transcatheter replacement (TPVR). The purpose this study was use TPVR simulator help doctors improve their surgical skills by simulating process in vitro. Methods: developed using three-dimensional (3D) printing technology under...
With the rising incidence of Mycoplasma pneumoniae pneumonia (MPP) in children, effective treatments are a research priority. This review compares MPP children using traditional Chinese medicine (TCM) and western medicine, highlighting recent advancements. Western primarily uses antibiotics to control pathogens, whereas TCM focuses on adjusting child's physical constitution treating based syndrome differentiation. Recent studies show that combining offers better outcomes than single-method...
New therapeutic approaches are needed for hepatocellular carcinoma (HCC), which is the most common primary malignancy of liver. Bispecific T-cell engagers (BiTE) can effectively redirect T cells against tumors and show a strong anti-tumor effect. However, potential immunogenicity, complexity, high cost significantly limit their clinical application. In this paper, we used hepatoma cells-specific aptamer TLS11a anti-CD3 to establish an aptamer/antibody bispecific system (AAbs), TLS11a/CD3,...
Abstract Objective: PhytoSERM is a selective estrogen receptor beta (ERβ) modulator comprised of three phytoestrogens: genistein, daidzein, and S-equol. The formulation promotes estrogenic action in the brain while largely inactive or inhibitory reproductive tissue. A phase Ib/IIa clinical trial (ClinicalTrial.gov ID: NCT01723917) demonstrated safety pharmacokinetics profile PhytoSERM. While this study was not powered for efficacy analysis, we conducted pilot, retrospective analysis to...
There are limited studies on neuroprotection from repeated subconcussive head impacts (RSHI) following docosahexaenoic acid (DHA) + eicosapentaenoic (EPA) supplementation in contact sports athletes. We performed a randomized, placebo-controlled, double-blinded, parallel-group design trial to determine the impact of 26 weeks DHA+EPA (n = 12) vs. placebo (high-oleic safflower oil) 17) serum concentrations neurofilament light (NfL), biomarker axonal injury, and inflammatory cytokines...
The objective of this study was to compare high supplementary doses (125 µg/kg) vitamin D3 (VD3) or 25-hydroxyvitamin (25-OHD3) with commercial (62.5 VD3 on laying performance, eggshell quality and ultrastructure, plasma calcium levels in late period hens. A total 1512 Roman Gray (60-week-old) hens were allotted into three treatments 12 replicates 42 birds each replicate. During the 12-week trial period, layers fed a basal diet supplemented different 25-OHD3 µg/kg control group, CON; 125...
Aging and endocrine transition states can significantly impact inflammation across organ systems. Neuroinflammation is well documented in Alzheimer disease (AD). Herein, we investigated neuroinflammation that emerges during mid-life aging, chronological endocrinological, the female brain as an early initiating mechanism driving AD risk later life. Analyses were conducted a translational rodent model of endocrinological aging followed by validation transcriptomic profiles from women versus...