The intratracheal administration of a perfluorocarbon liquid during continuous positive-pressure ventilation (partial ventilation) improves lung function in animals with surfactant deficiency. Whether partial is effective the treatment infants severe respiratory distress syndrome not known.

Abstract Introduction High‐flow nasal cannula therapy (HFNC) has been shown to be more effective than continuous positive airway pressure (CPAP) in reducing intubations and ventilator days. HFNC likely provides mechanisms support respiratory efficiency beyond application of distending pressure. We reason that washout nasopharyngeal dead space impacts CO 2 removal along with oxygenation. The aim this study was demonstrate the flow dependence reduction improved oxygenation during on leak...

In the clinical setting, nasal cannulas are frequently used to deliver supplemental oxygen neonates and not believed affect general respiratory status. contrast, it was hypothesized that changes associated with cannula gas flow may be related in part generation of positive end-distending pressure. To test this hypothesis, alterations esophageal pressure were quantified as an indication thoracoabdominal motion breathing patterns 13 preterm infants at levels 0.5, 1, 2 L/min delivered by outer...

Abstract Pulmonary mechanics, using a two factor least mean square analysis technique, were determined in 22 preterm neonates with respiratory failure. The system is modelled as linear mechanical system. Concurrent signals of airflow and transpulmonary pressure utilized to calculate values dynamic lung compliance pulmonary resistances; these determinations made over the entire tidal volume range. In addition, resistive work breathing, time constants, scalar records sequential breaths,...

To differentiate the effects of gas and liquid ventilation on cardiopulmonary function during early development, we compared clinical, physiological, histological profiles gas- liquid-ventilated preterm lambs (n = 16; 108–116 days gestation). Immediately after cesarean section delivery, commenced using delivered by a volume ventilator 9) or perfluorochemical 7) mechanically assisted system. Pulmonary exchange, acid-base status, vital signs, respiratory compliance were assessed 3-h protocol;...

This article reviews the application of human airway Calu-3 cell line as a respiratory model for studying effects gas concentrations, exposure time, biophysical stress, and biological agents on epithelial cells. cells are grown to confluence at an air-liquid interface permeable supports. To conditions treatment modalities, monolayers placed in environmental chamber, exposed specific levels oxygen or other therapeutic modalities such positive pressure medications assess effect interventions...

The authors evaluated gas exchange, pulmonary function, and lung histology during perfluorocarbon liquid ventilation (LV) when compared with (GV) in the setting of severe respiratory failure.The efficacy LV failure has been premature animals surfactant deficiency. However, very little work performed evaluating older animal models adult distress syndrome (ARDS).A stable model injury was induced 12 young sheep weighing 16.4 +/- 3.0 kg using right atrial injection 0.07 mL/kg oleic acid followed...

Thoracoabdominal asynchrony (TAA) has long been thought clinically useful in the assessment of airflow obstruction (AO) infants. To test hypothesis that measurement TAA is lung mechanics infants with AO, we have used respiratory inductive plethysmography (RIP) to quantify TAA. We compared changes before and after aerosolized bronchodilator (BD) administration 13 Abdominal wall (AB) rib cage (RC) motion were displayed on an X-Y recorder a Lissajous figure. Asynchrony between RC AB was...

Pulmonary vascular resistance was investigated in the fluorocarbon-filled lung an situ isolated preparation. Lungs were perfused at constant flow (100 ml X min-1 kg-1) with whole blood from a donor cat. left atrial pressure held zero pressure. Measurements of pulmonary arterial enabled calculation resistance. Regional changes determined by microsphere technique. During quasi-static deflation over range 0–30 mmHg, dependent alveolar consistently greater for volume fluorocarbon than gas, each...

Humidification of inspired gas is important for patients receiving respiratory support. High-flow nasal cannula (HFNC) effectively provides temperature and humidity-controlled to the airway. We hypothesized that various levels humidification would have differential effects on airway epithelial monolayers. Calu-3 monolayers were placed in environmental chambers at 37°C with relative humidity (RH) < 20% (dry), 69% (noninterventional comparator), >90% 4 8 hours 10 L/min room air. At hours, cell...

To determine the influence of body position on chest wall and pulmonary function, we studied ventilatory, mechanics, thoracoabdominal motion profiles in 20 preterm infants recovering from respiratory disease who were positioned both supine prone position. Thoracoabdominal was assessed measurements relative rib cage abdominal movement calculated phase angle (an index synchrony) abdomen Lissajous figures. The ventilatory function simultaneous transpulmonary pressure, airflow, tidal volume....

Objective To investigate the effects of lung lavage with oxygenated liquid perfluorochemical on gas exchange, mechanics, and cardiac function in animals acute injury. Design Prospective, randomized, controlled trial. Setting Animal laboratory. Subjects Eight adult cats (2 to 4 kg, random sex). Interventions Two insults were combined cause injury: oleic acid infusion saline whole-lung wash. Animals assigned either control or treatment group which consisted a (Rimar 101) lavage....

Abstract Asynchronous or paradoxic motion between the rib cage and abdomen may be seen in infants with lung disease. We have recently shown that after bronchodilator administration, degree of asynchrony decreases proportionately to improvement mechanics. However, whether such thoraco‐abdominal (TAA) is a useful indicator function cross‐sectional population, i.e., correlates baseline mechanics, unknown. Therefore, we quantitated TAA using respiratory inductive plethysmography during quiet...