A5070399750- Traditional Chinese Medicine Studies
- Traditional Chinese Medicine Analysis
- Heart Failure Treatment and Management
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Plant-based Medicinal Research
- Cardiac Health and Mental Health
- Cardiac electrophysiology and arrhythmias
- Coronary Interventions and Diagnostics
- Cardiac Fibrosis and Remodeling
- Acupuncture Treatment Research Studies
- Medical Research and Treatments
- Cardiovascular and exercise physiology
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Angiogenesis and VEGF in Cancer
- Ginseng Biological Effects and Applications
- Healthcare and Venom Research
- Metabolomics and Mass Spectrometry Studies
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Viral Infections and Immunology Research
- Cancer Treatment and Pharmacology
- Pharmacological Effects of Natural Compounds
- Lipid metabolism and disorders
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2016-2025
Boston University
2022
Beijing University of Chinese Medicine
2022
Second Military Medical University
2022
Shanghai Changzheng Hospital
2022
Boston Medical Center
2022
University Medical Center
2022
Kaiser Permanente
2022
Maastricht University
2022
Acorda Therapeutics (United States)
2022
Myocardial fibrosis is a significant pathological basis of heart failure. Overactivation the ERK1/2 and JNK1/2 signaling pathways MAPK family members synergistically promotes proliferation myocardial fibroblasts accelerates development fibrosis. In addition to some small molecule inhibitors Western drugs, many Chinese medicines can also inhibit activity JNK1/2, thus slowing down fibrosis, are generally safe effective. However, specific biological mechanisms in still need be fully understood,...
Background and Purpose: Atherosclerosis is an underlying cause of coronary heart disease. Foam cell, a hallmark atherosclerosis, prominently derived from monocyte-differentiated macrophage, vascular smooth muscle cells (VSMCs) through unlimitedly phagocytizing oxidized low-density lipoprotein (oxLDL). Therefore, the inhibition monocyte adhesion to endothelium uptake oxLDL might be breakthrough point for retarding atherosclerosis. Formononetin, isoflavone extracted Astragalus membranaceus,...
Background: Hypertension is one of the most challenging public health problems worldwide. Previous studies suggested that Songling Xuemaikang capsule (SXC)—a Chinese herbal formula—was effective for essential hypertension. However, efficacy SXC monotherapy hypertension remains unclear. We aimed to compare blood pressure (BP)–lowering and safety versus losartan in patients with Methods: In this multicenter, randomized, double-blind, noninferiority trial China, 18 65 years age mild were...
Doxorubicin (DOX) is one of the most effective chemotherapy agents used in treatment hematological and solid tumors, however, it causes dose-related cardiotoxicity that may lead to heart failure patients. One major reasons was increased reactive oxygen species (ROS) production. Ginsenoside Rg3 (Rg3), powerful free radical scavengers possessed cardioprotective effects. Nevertheless, has low aqueous solubility oral bioavailability, limiting its Herein, we encapsulated through spontaneous...
In patients with heart failure (HF), improved left ventricular ejection fraction (LVEF) classification is closely associated increased survival rates. However, even receiving guideline-directed medical therapy (GDMT) still struggle poor cardiac function and high rates of readmission. Enhancing in HF reducing the occurrence adverse events (AEs) remain critical challenges at present. This study was designed to evaluate effects Qishen Yiqi dripping pills (QSYQ) on EF ischaemic (IHF). a...
Qishen Yiqi dripping pills (QSYQ) may be beneficial in patients with ischaemic heart failure (IHF). We aimed to assess the efficacy and safety of QSYQ administered together guideline-directed medical therapy IHF.This prospective randomized, double-blind, multicentre placebo-controlled study enrolled 640 IHF between March 2012 August 2014. Patients were randomly assigned receive 6 months or placebo addition standard treatment. The primary outcome was min walking distance at months. Among 638...
Background . Shenfu injection (SFI) has shown a remarkable therapeutic effect in patients with chronic heart failure (CHF) during the acute phase of symptom aggravation since it became commercially available 1987. However, SFI not been validated standard clinical study. As pilot trial, this study aimed to evaluate safety and efficacy for treatment CHF phase. Methods A total 160 experiencing were enrolled randomly assigned receive placebo (placebo group, 150 ml glucose (GS)) or (SFI 50 + 100...
Atherosclerosis is a major pathogenic driver of cardiovascular diseases. Foam cell formation plays key role in atherogenesis, which affected by lipid disorder and inflammation. Therefore, inhibition foam therapeutic approach for atherosclerosis treatment. Total flavone Astragalus membranaceus (TFA) extracted from A. that has protective effect on disease. However, the TFA underlying mechanism remains unknown. In this study, we determined whether could inhibit uncovered mechanism. vivo , ApoE...
The discovery of regulatory cell death processes has driven innovation in cardiovascular disease (CVD) therapeutic strategies. Over the past decade, ferroptosis, an iron-dependent form regulated by excessive lipid peroxidation, been shown to drive development multiple CVDs. This review provides insights into evolution concept similarities and differences with traditional modes programmed (e.g., apoptosis, autophagy, necrosis), as well core mechanisms ferroptosis (including cystine/glutamate...
Background and Purpose: Atherosclerosis is vascular disease of chronic inflammation lipid disorder, which a major cause coronary heart disease. Foam cell formation key progress during the atherosclerosis development. Insulin-like growth factor (IGF)-1 hormone that plays crucial role in growth, metabolism, homeostasis. Previous studies have demonstrated increase circulating IGF-1 can reduce atherosclerotic burden. However, active characterized with poor tissue retention at very low level...
Cardiac metabolic remodeling is recognized as an important hallmark of heart failure (HF), while strategies that target energy metabolism have therapeutic potential in treating HF.Shen-Fu formula (S-F) a standardized herbal preparation frequently used clinical practice and promising combinatorial therapy for HF-related remodeling.Herein, we performed untargeted multi-omics analysis using transcriptomics, proteomics, metabolomics on HF mice induced by transverse aortic constriction...
Ginsenoside Rg3 is one of the main active ingredients in ginseng. Here, we aimed to confirm its protective effect on heart function transverse aortic coarctation (TAC)-induced failure mice and explore potential molecular mechanisms involved. The effects ginsenoside mitochondrial were investigated by treating TAC-induced mice. mechanism for improving with was predicted through integrative analysis proteome plasma metabolome. Glucose uptake myocardial insulin sensitivity evaluated using...
Acute exacerbation is a common cause of hospitalization in patients with chronic heart failure, and coronary disease the most cause. Shenfu injection, Traditional Chinese Medicine widely used adjuvant treatment acute shows some effect improving symptoms quality life, but it lacks rigorous clinical evaluation research reports. This paper describes protocol for assessment injection loading failure.This adopts design prospective, randomized, multicenter, blind imitation, placebo-controlled...