A5101454681- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cholesterol and Lipid Metabolism
- Reproductive biology and impacts on aquatic species
- Animal Genetics and Reproduction
- Cancer, Lipids, and Metabolism
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Sperm and Testicular Function
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Peroxisome Proliferator-Activated Receptors
- Reproductive Biology and Fertility
- interferon and immune responses
- Drug Transport and Resistance Mechanisms
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Aquaculture Nutrition and Growth
- CRISPR and Genetic Engineering
- Tryptophan and brain disorders
- Lipid metabolism and disorders
- Kruppel-like factors research
- Gut microbiota and health
- Cancer-related Molecular Pathways
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
Ningxia Medical University
2018-2025
Southwest University
2021-2025
Hubei University
2025
Henan Provincial People's Hospital
2018-2025
State Key Laboratory of Medicinal Chemical Biology
2020-2024
Nankai University
2018-2024
Ningxia Medical University General Hospital
2018-2024
Beijing Tongren Hospital
2024
Capital Medical University
2024
Macau University of Science and Technology
2024
Background and Purpose: Atherosclerosis is an underlying cause of coronary heart disease. Foam cell, a hallmark atherosclerosis, prominently derived from monocyte-differentiated macrophage, vascular smooth muscle cells (VSMCs) through unlimitedly phagocytizing oxidized low-density lipoprotein (oxLDL). Therefore, the inhibition monocyte adhesion to endothelium uptake oxLDL might be breakthrough point for retarding atherosclerosis. Formononetin, isoflavone extracted Astragalus membranaceus,...
Abstract Many regions across the globe are grappling with water scarcity issues, prompting exploration of innovative harvesting techniques. While development high‐performance materials has been widely documented, these technologies often rely on a singular source limited efficiency. This study presents dual‐functional copper Janus system that facilitates continuous freshwater by integrating seawater desalination powered solar energy during daylight hours and fog collection night morning...
<b><i>Purpose:</i></b> To investigate the potential protective effects of curcumin on retina in diabetic rats. <b><i>Methods:</i></b> An experimental rat model was induced by a low dose streptozotocin combined with high-energy diet. Rats which had blood glucose levels ≥11.6 mmol/L were used as The rats randomly divided into 3 groups: no treatment (DM), treated 100 mg/kg (DM + Cur mg/kg), and 200 mg/kg). Curcumin orally administered daily for 16...
Rationale: Vascular microcalcification increases the risk of rupture vulnerable atherosclerotic lesions. Inhibition ERK1/2 reduces atherosclerosis in animal models while its role vascular calcification and underlying mechanisms remains incompletely understood. Methods: Levels activated ERK1/2, DKK1, LRP6 BMP2 human calcific aortic valves were determined. ApoE deficient mice received inhibitor (U0126) treatment, followed by determination atherosclerosis, miR-126-3p production. C57BL/6J used...
To systematically compare and rank ocular measurements with optical ultrasound biometers based on big data.PubMed, Embase, the Cochrane Library US trial registry ( www.gov ) were used to search trials published up October 22nd, 2020. We included comparative studies reporting following parameters measured by at least two devices: axial length (AL), flattest meridian keratometry (Kf), steepest (Ks), mean (Km), astigmatism (AST), vectors J0 J45, anterior chamber depth (ACD), aqueous (AQD),...
Oxidative stress significantly contributes to ageing and disease, with antioxidants holding promise in mitigating its effects. Functional foods rich flavonoids offer a potential strategy mitigate oxidative damage by free radicals. We investigated the protective effects of mulberry leaf (MLF) against H2O2-induced HepG2 cells. It assessed inhibitory effect MLF (62.5–500 μg/mL) on analyzing cellular morphology markers, including ROS production, mitochondrial membrane potential, antioxidant...
The liver X receptor (LXR) agonist T317 reduces atherosclerosis but induces fatty liver. Metformin activates energy metabolism by activating AMPKα. In this study, we determined if interactions between metformin and could inhibit without activation of hepatic lipogenesis.Apolipoprotein E-deficient mice were treated with T317, or both agents, in a high-fat diet for 16 weeks. Then, samples aorta, liver, macrophage serum collected to determine atherosclerotic lesions, lipid profiles expression...
Abstract Gonadotropin-releasing hormone (Gnrh) plays important roles in reproduction by stimulating luteinizing release, and subsequently ovulation sperm ultimately controlling many species. Here we report on a new role for this decapeptide. Surprisingly, Gnrh3-null zebrafish generated CRISPR/Cas9 exhibited male-biased sex ratio. After the dome stage, number of primordial germ cells (PGCs) gnrh3-/- fish was lower than that wild-type, an effect partially rescued gnrh3 overexpression. A...
Background and Purpose Atherosclerosis is one of the underlying causes cardiovascular disease. Formation foam cells necrotic core in plaque a hallmark atherosclerosis, which results from lipid deposition, apoptosis, inflammation macrophages. Macrophage autophagy critical anti‐atherogenic process defective aggravates atherosclerosis by enhancing cell formation, inflammation. Hence, can be strategy for treatment. Calycosin, flavonoid Radix Astragali , displays anti‐oxidant anti‐inflammatory...
Heart failure is the leading cause of death worldwide. Compound Danshen Dripping Pill (CDDP) or CDDP combined with simvastatin has been widely used to treat patients myocardial infarction and other cardiovascular diseases in China. However, effect on hypercholesterolemia/atherosclerosis-induced heart unknown. We constructed a new model induced by hypercholesterolemia/atherosclerosis apolipoprotein E (ApoE) LDL receptor (LDLR) dual deficient (ApoE-/-LDLR-/-) mice investigated plus low dose...
Abstract Sepsis is an infection‐triggered, rapidly progressive systemic inflammatory syndrome with a high mortality rate. Currently, there are no promising therapeutic strategies for managing this disease in the clinic. Heparanase plays crucial role pathology of sepsis, and its inhibition can significantly relieve related symptoms. Here, novel heparanase inhibitor CV122 rationally designed synthesized, potential sepsis Lipopolysaccharide (LPS) Cecal Ligation Puncture (CLP)‐induced mouse...
Cortisol is the major glucocorticoid, which considered to be a key factor linking environmental stress and sex differentiation in teleosts. In present study, we explored possible role of cortisol protogynous hermaphroditic swamp eel, Monopterus albus . We cloned characterized full-length cDNA sequences glucocorticoid receptor genes, gr1 gr2 A novel alternative splicing variant ( gr1b ) was also discovered, lacked 27-bp nucleotide insertion , resulting nine-amino-acid deletion GR1. Real-time...
Herein, alkoxy-bridged triphenylene and perylene monoimide diester dyads (TP-Cn-PMI, n = 4, 6, 10) were designed synthesized, their films successfully prepared on the surfaces of platinum...
An association between the coronavirus disease 2019 (COVID-19) and a reduction in male semen parameters has been described, but no large-scale population analyses have conducted. This study aimed to investigate effects of COVID-19 pandemic on quality. Based ecological comparative study, our analyzed impact quality after national liberalization restrictions China at end 2022, aiming explore quality, provide basis for subsequent epidemics reproduction as well clinical diagnosis treatment. It...
Abstract Systemic inflammatory response syndrome (SIRS) and organ dysfunction make it challenging to predict which major trauma patients are at risk of developing sepsis. Additionally, the unclear pathogenesis sepsis after contributes its high morbidity mortality. Identifying early predictive diagnostic biomarkers, as well exploring related metabolic pathways, is crucial for improving prevention, diagnosis, treatment. This study prospectively analyzed plasma samples from with severe...
Abstract Sepsis after trauma and trauma-induced SIRS have similar symptoms, making their differentiation challenging. Therefore, biomarkers are needed to differentiate between sepsis SIRS. We hypothesized that following induces distinct alterations in blood metabolism compared sought identify metabolite could the two. In this retrospective study, existing metabolomics data from 60 patients without SIRS, 40 with 50 non-trauma control cases were analyzed. Among traumatic 16 developed (SDS...
Abstract Ghrelin is a recently discovered brain–gut peptide in fish and mammals. It has two main physiological functions—stimulating growth hormone secretion regulating appetite. To investigate the biological function of ghrelin appetite regulation grass carp Ctenopharyngodon idellus , full‐length cDNA sequence gene was obtained by RT‐PCR rapid amplification ends methods. Homology analysis indicated that conserved teleosts. The consists four exons three introns, which similar to common carp,...