A5004819710- Reproductive biology and impacts on aquatic species
- Aquaculture Nutrition and Growth
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Hypothalamic control of reproductive hormones
- Amphibian and Reptile Biology
- Neuroendocrine regulation and behavior
- Pharmaceutical and Antibiotic Environmental Impacts
- Regulation of Appetite and Obesity
- Environmental Toxicology and Ecotoxicology
- Aquaculture disease management and microbiota
- Estrogen and related hormone effects
- Fish Ecology and Management Studies
- Neurogenesis and neuroplasticity mechanisms
- Animal Behavior and Reproduction
- Animal Genetics and Reproduction
- Stress Responses and Cortisol
- Effects and risks of endocrine disrupting chemicals
- Ovarian function and disorders
- Physiological and biochemical adaptations
- Birth, Development, and Health
- Neuroscience and Neuropharmacology Research
- Zebrafish Biomedical Research Applications
- Neurobiology and Insect Physiology Research
- Petroleum Processing and Analysis
- MicroRNA in disease regulation
University of Ottawa
2016-2025
Ontario Genomics
2009-2022
Ottawa University
2022
Wilfrid Laurier University
2018-2021
University of New Brunswick
2012
University of Michigan
2009
National Water Research Institute
2009
University of Copenhagen
2008
University of Liverpool
2008
National University of Singapore
2008
The pulp and paper industry in Canada is developing technology for the production use of nanocrystalline cellulose (NCC). A key component developmental work an assessment potential environmental risks. Towards this goal, NCC samples as well carboxyl methyl (CMC), a surrogate parent cellulosic material, were subjected to ecotoxicological evaluation. This involved toxicity tests with rainbow trout hepatocytes nine aquatic species. most sensitive (EC20s between 10 200 mg/l) NCC, although...
In Canada, the use of botanical natural health products (NHPs) for anxiety disorders is on rise, and a critical evaluation their safety efficacy required. The purpose this study was to determine whether commercially available botanicals directly affect primary brain enzymes responsible γ-aminobutyric acid (GABA) metabolism. Anxiolytic plants may interact with either glutamic decarboxylase (GAD) or GABA transaminase (GABA-T) ultimately influence levels neurotransmission. Two in vitro rat...
Abstract A novel pharmacological mechanism of action for the anxiolytic botanical Melissa officinalis L. (lemon balm) is reported. The methanol extract was identified as a potent in vitro inhibitor rat brain GABA transaminase (GABA‐T), an enzyme target therapy anxiety, epilepsy and related neurological disorders. Bioassay‐guided fractionation led to identification isolation rosmarinic acid (RA) triterpenoids, ursolic (UA) oleanolic (OA) active principles. Phytochemical characterization crude...
We investigated the effects of fluoxetine, a selective serotonin reuptake inhibitor, on neuroendocrine function and reproductive axis in female goldfish. Fish were given intraperitoneal injections fluoxetine twice week for 14 days, resulting five 5 μg fluoxetine/g body wt. measured monoamine neurotransmitters serotonin, dopamine, norepinephrine addition to their metabolites with HPLC. Homovanillic acid, metabolite dopaminergic pathway, increased significantly hypothalamus. Plasma estradiol...
Abstract N6-methyladenosine (m6A), catalyzed by Mettl3 methyltransferase, is a highly conserved epigenetic modification in eukaryotic messenger RNA (mRNA). Previous studies have implicated m6A multiple biological processes, but the vivo function of has been difficult to study, because mettl3 mutants are embryonic lethal both mammals and plants. In this we used transcription activator-like effector nucleases generated viable zygotic mutant, Zmettl3m/m, zebrafish. We find that oocytes...
The global prevalence of depression is high during childbearing. Due to the associated risks mother and baby, selective serotonin reuptake inhibitor fluoxetine (FLX) often first line treatment. Given that FLX readily crosses placenta, a fetus may be susceptible disruptive effects this highly plastic stage development. Here, we demonstrate 6-day exposure fetus-relevant concentration at critical developmental suppresses cortisol levels in adult zebrafish (F 0 ). This effect persists for three...