A5080805362- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Reproductive Biology and Fertility
- Corneal surgery and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Autophagy in Disease and Therapy
- Mesenchymal stem cell research
- Chronic Kidney Disease and Diabetes
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Drug Transport and Resistance Mechanisms
- Glaucoma and retinal disorders
- Peripheral Nerve Disorders
- Renal and related cancers
- RNA and protein synthesis mechanisms
- Nuclear Structure and Function
- Hereditary Neurological Disorders
- CRISPR and Genetic Engineering
- Long-Term Effects of COVID-19
- 3D Printing in Biomedical Research
- Advanced Glycation End Products research
- Kruppel-like factors research
- RNA modifications and cancer
- Management of metastatic bone disease
- Pancreatic function and diabetes
Xiamen University
2017-2025
Eye Center
2025
Harbin Medical University
2019-2024
Second Affiliated Hospital of Harbin Medical University
2019-2024
Guangdong Medical College
2020-2024
Second Affiliated Hospital of Guangzhou Medical University
2024
Guangzhou Medical University
2024
Jinan University
2021-2023
Xi'an Jiaotong University
2023
First Affiliated Hospital of Wannan Medical College
2022
Purpose: Patients diagnosed with diabetes are inclined to have abnormalities on stability of tear film and disorder meibomian gland (MG). This study aims explore the pathological change MG induced by in a rat model. Methods: Sprague-Dawley (SD) rats were intraperitoneally injected streptozotocin (STZ) establish diabetic animal Lipid accumulation was detected Oil Red O staining LipidTox staining. Cell proliferation status determined Ki67 P63 immunostaining, whereas cell apoptosis confirmed...
Abstract Metabolic reprogramming to glycolysis is closely associated with the development of chronic kidney disease (CKD). Although it has been reported that phosphofructokinase 1 (PFK) a rate-limiting enzyme in glycolysis, role platelet isoform PFK (PFKP) fibrosis initiation and progression as yet poorly understood. Here, we investigated whether PFKP could mediate interstitial by regulating proximal tubular epithelial cells (PTECs). We induced overexpression or knockdown renal tubules via...
Corneal neovascularization (CNV) is one of the main factors that induce blindness worldwide. However, current medical treatments cannot achieve non-invasive and safe inhibition CNV. A noninvasive photoacoustic imaging (PAI)-guided method purposed for regression PAI can monitor oxygen saturation cornea blood vessels through endogenous contrast hemoglobin trace administrated drugs by themselves as exogenous agents. An indocyanine green (ICG)-based nanocomposite (R-s-ICG) prepared CNV treatment...
Purpose: To investigate the ocular surface changes during progress of Sjögren's Syndrome (SS), using a previously described IL14α transgenic mice (IL14α TG) SS model. Methods: The TG and C57BL/6 wild-type (WT) female were evaluated at age six, nine, 12, 15, 18 months. Slit lamp microscopy observation, Oregon green dextran staining, Schirmer test, periodic-acid–Schiff staining assessed. Immunohistochemistry, immunofluorescence, associated gene expression analysis by qPCR ELISA performed in...
Background and Purpose Atherosclerosis is one of the underlying causes cardiovascular disease. Formation foam cells necrotic core in plaque a hallmark atherosclerosis, which results from lipid deposition, apoptosis, inflammation macrophages. Macrophage autophagy critical anti‐atherogenic process defective aggravates atherosclerosis by enhancing cell formation, inflammation. Hence, can be strategy for treatment. Calycosin, flavonoid Radix Astragali , displays anti‐oxidant anti‐inflammatory...
Increasing evidence suggests that human cholestasis is closely associated with the accumulation and activation of hepatic macrophages. Research indicates PPARγ exerts liver protective effects in cholestatic disease (CLD), particularly by ameliorating inflammation fibrosis, thus limiting progression. However, existing agonists, such as troglitazone rosiglitazone, have significant side prevent their clinical application treatment CLD. In this study, we found tectorigenin alleviates...
Purpose: To investigate a novel strategy in constructing tissue-engineered corneal stromal equivalent based on amniotic membrane and keratocytes. Methods: The ultrathin (UAM) was laminated, with cells (CSCs) distributed between the space of layered UAMs. Calcein AM staining used to evaluate cellular viability, morphology, arrangement. Immunostaining, qRT-PCR, Western blot were performed detect gene protein expression Optical coherence tomography visualized cross sections thickness UAM...
This study aims to investigate the molecular mechanism of Adenovirus type 36 (Ad36) in adipocyte differentiation and glucolipid metabolism.Rat obesity model was established by Ad36 infection high-fat diet, respectively. Comparison body weight, clinical biochemical indicators, insulin sensitivity lipid heterotopic deposition between these two models performed. Ad36-induced vitro also established. The binding rate FoxO1, PPARγ its target gene promoter detected using ChIP. mRNA protein...
Obesity and associated metabolic fatty liver diseases (MAFLD) are strongly with dysfunction of glucose lipid metabolism. AMPKα PPARα key regulators in the homeostasis, indicating that novel agents to activate them promising therapeutic approaches for syndrome. Noticeably, as a natural anthraquinone derivative extracted from rhubarb, danthron can vitro. However, protective effect on obesity MAFLD vivo, well underlying mechanism remains unknown. In this study, was induced C57BL/6J mice by high...
Abstract Aims/hypothesis Type 2 diabetes is associated with a reduction in skeletal muscle mass; however, how the progression of sarcopenia induced and regulated remains largely unknown. We aimed to find out whether specific microRNA (miR) may contribute atrophy type diabetes. Methods Adeno-associated virus (AAV)-mediated miR-193b overexpression C57BLKS/J mice, deficiency db/db mice were used explore function loss. In C57BL/6 J tibialis anterior-specific deletion 3-phosphoinositide-dependent...
Introduction Carpal tunnel syndrome (CTS) is a common compression neuropathy of the median nerve in wrist. Early diagnosis CTS essential for selecting treatment options and assessing prognosis. The current based on patient's clinical symptoms, signs, an electromyography (EMG) test. However, they have some limitations. Recently, ultrasound has been adopted as adjunct diagnostic tool (EMG). Ultrasound non-invasive cost-effective technique. It provides dynamic display morphological changes...
Background and purpose: FXR is a promising target for the treatment of human cholestatic liver disease (CLD). SIRT1 deacetylase which promotes activity through deacetylating FXR. Pterostilbene (PTE) an activator SIRT1. However, role PTE in cholestasis has so far not been investigated. We examined whether alleviate injury DDC or ANIT-induced experimental cholestasis, explored underlying mechanisms. Experimental approach: Mice with DDC- were treated different dose PTE. Primary hepatocytes bone...
Diabetic kidney disease (DKD) is the leading cause of end-stage renal and has become a serious public health problem worldwide. Dipeptidyl peptidase-4 (DPP4) inhibitors, an emerging drug for treatment diabetes, have been found to renoprotective effects in addition glucose-lowering therefore potential be modality DKD. Lobeliae Chinensis Herba (LCH), traditional Chinese herb widely used recently hypoglycaemic mechanism related inhibition DPP4. Firstly, analysis single-cell sequencing data from...
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Clinical features are traditionally used to predict DKD, yet with low diagnostic efficacy. Most recent biomarkers DKD based on transcriptomics and metabolomics; however, they also should be in combination many other predictive indicators. The purpose this study was thus identify a simplified class blood capable predicting risk developing DKD. Gene Expression Omnibus database screened for biomarkers, differentially...
Background To investigate the dynamic changes of urine N6-methyladenosine (m6A) levels in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) evaluate clinical significance. Methods First, m6A were examined compared among 62 T2DM, 70 DN, 52 age- gender-matched normal glucose tolerant subjects (NGT) by using a MethyIFIashTM Urine Quantification Kit. Subsequently, we concentrations between different stages DN. Moreover, statistical analysis was performed to association...
Background. Mammalian target of rapamycin (mTOR) is crucial for endothelial function. This study aimed at assessing whether the glucagon-like peptide-1 (GLP-1) analogue liraglutide has a protective effect on function via mTOR signaling pathway. Methods. Human umbilical vein cells (HUVECs) were administered (100 nM) 0, 10, 30, 60, 720, and 1440 minutes, respectively. Then, expression phosphorylation levels mTOR, mTOR-Raptor complex (mTORC1), mTOR-Rictor (mTORC2) determined by Western blot...
Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a severe adverse caused by specific drugs. However, little information available about sequelae following DIHS/DRESS resolution from an endocrinologist's perspective. This study aimed to investigate the endocrine DIHS/DRESS, clinical feature etiology. We retrospectively analyzed patients diagnosed in Peking Union Medical College Hospital (PUMCH) during period of 1 January 2012 31...
Backgroud This study’s objectives were to compare the clinical, perinatal, and obstetrical outcomes of patients with different estradiol (E 2 ) levels in fresh single-blastocyst-transfer (SBT) cycles under an early follicular phase prolonged regimen on day trigger. Methods We recruited SBT ( n = 771) undergoing protocols β-hCG values above 10 IU/L between June 2016 December 2018. Patients who met inclusion exclusion criteria divided into four groups according their serum E level percentages...