A5103017782- Pharmacological Effects of Natural Compounds
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- Botulinum Toxin and Related Neurological Disorders
- Alzheimer's disease research and treatments
- Sepsis Diagnosis and Treatment
- Diphtheria, Corynebacterium, and Tetanus
- Cancer, Stress, Anesthesia, and Immune Response
- Cardiac Ischemia and Reperfusion
- RNA Research and Splicing
- Inflammasome and immune disorders
- History of Medical Practice
- Long-Term Effects of COVID-19
- RNA modifications and cancer
- Advanced Breast Cancer Therapies
- Histone Deacetylase Inhibitors Research
- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- Influenza Virus Research Studies
- Genomics and Chromatin Dynamics
Air Force Medical University
2017-2025
Ningxia Medical University
2019-2024
Ningxia Medical University General Hospital
2022-2024
Hubei Cancer Hospital
2020-2024
Huazhong University of Science and Technology
2017-2024
Xilinx (United States)
2024
Anhui Medical University
2014-2023
Columbia University
2023
Columbia University Irving Medical Center
2022-2023
First Affiliated Hospital of Anhui Medical University
2021-2023
Macroautophagy/autophagy deficit induces intracellular MAPT/tau accumulation, the hallmark pathology in Alzheimer disease (AD) and other tauopathies; however, reverse role of MAPT accumulation autophagy neurodegeneration is not clear. Here, we found that overexpression human wild-type full-length MAPT, which models pathologies as seen sporadic AD patients, induced deficits via repression autophagosome-lysosome fusion leading to significantly increased LC3 (microtubule-associated protein 1...
Recent advances in human blastoids have opened new avenues for modeling early development and implantation. One limitation of our first protocol blastoid generation was relatively low efficiency. We now report an optimized the efficient large quantities high-fidelity from naive pluripotent stem cells. This enabled proteomics analysis that identified phosphosite-specific signatures potentially involved derivation and/or maintenance signaling states blastoids. Additionally, we uncovered...
Patients with chronic hepatitis B (CHB) undergoing interferon (IFN)-α-based therapies often exhibit a poor HBeAg serological response. Thus, there is an unmet need for new aimed at CHB. This study comprised two clinical trials, including 130 CHB patients, who were treatment-naïve; in the first, 92 patients systematically analyzed ex vivo interleukin-2 receptor (IL-2R) expression and inhibitory molecules after receiving Peg-IFN-α-2b therapy. In our second trial, 38 non-responder whom IFN-α...
Objective: Apoptosis and autophagy are significant factors of sepsis induced myocardial injury (SIMI). XBJ improves SIMI by PI3K/AKT/mTOR pathway. Present study is devised to explore the protective mechanism in continuous treatment caused CLP. Methods: Rat survival was first recorded within 7 days. Rats were randomly assigned three groups: Sham group, CLP group. The animals each group divided into 12 h 1 d, 2 3 d 5 according administration time hours, day, days, days or respectively....
Aims: This study aimed to evaluate the effects of VC on SIMI in rats. Methods: In this study, survival rate high dose for was evaluated within 7 days. Rats were randomly assigned three groups: Sham group, CLP and (500 mg/kg i.v.) group. The animals each group treated with drugs 1 day, 3 days or 5 days, respectively. Echocardiography, myocardial enzymes HE used detect cardiac function. IL-1β, IL-6, IL-10 TNF-α) serum measured using ELISA kits. Western blot proteins related apoptosis,...
Abstract Translationally controlled tumor protein (TCTP), also known as histamine-releasing factor (HRF) or fortilin, is a highly conserved found in various species. To date, multiple studies have demonstrated the crucial role of TCTP wide range cellular pathophysiological processes, including cell proliferation and survival, cycle regulation, death, well migration movement, all which are major pathogenic mechanisms tumorigenesis development. This review aims to provide an in-depth analysis...
Disuse bone loss is prone to occur in individuals who lack mechanical stimulation due prolonged spaceflight or extended bed rest, rendering them susceptible fractures and placing an enormous burden on social care; nevertheless, the underlying molecular mechanisms of caused by unloading have not been fully elucidated. Numerous studies focused epigenetic regulation disuse loss; yet limited research has conducted impact RNA modification formation response conditions. In this study, we...
Abstract Background and Aim The aim of our study was to investigate the immunomodulatory effect short‐term efficacy long‐term prognosis decompensated liver cirrhosis patients caused by hepatitis B after a double transplantation with human umbilical cord mesenchymal stem cells (hUCMSCs). Methods Fifty inpatients were recruited given same medical treatments, receiving hUCMSCs injection intravenously. Fifty‐three (Group B) matched for age, sex, baseline alanine aminotransferase, aspartate...
Background: Shaoyao-Gancao Decoction (SG-D) is a famous classical Chinese prescription that has been used in the treatment of numerous kinds diseases. However, its mechanism action Gastric carcinoma (GC) not clear. Methods: The active ingredients and targets SG-D were screened using network pharmacology, GC-related retrieved through several databases. protein-protein interaction was then further constructed GO KEGG enrichment analysis performed. Subsequently, molecular docking carried out....
To describe the clinical characteristics, treatments, and outcomes of tetanus determine most appropriate focus for prevention treatment to reduce morbidity mortality in China.Four databases, including Chinese Bio-Medical Literature Database, National Knowledge Infrastructure, Scientific Journal Wan-fang Data, were searched from 1 January, 2000 30 October, 2022.In total, 151 articles 6084 patients met inclusion criteria. Additionally, 5925 had their gender recorded detail, among which 66.67%...
Background: Cisplatin (DDP) is one of the important chemotherapy drugs for patients with advanced gastric cancer and metastasis, but its resistance a bottleneck problem that affects clinical efficacy patient survival. Eremias multiocellata (EM) traditional Chinese herbal medicine, which has been used in treatment precancerous lesions, cancer, liver fibrosis, other digestive diseases. However, mechanism reducing to still unclear. Methods: We MTT assay evaluate proliferative viability parental...
Gastric cancer (GC) is one of the most common types worldwide, and its prevention treatment methods have garnered much attention. As active ingredient licorice, 18β-glycyrrhetinic acid (18β-GRA) has a variety pharmacological effects. The aim this study was to explore effective target 18β-GRA in GC, order provide ideas for clinical GC.
Objective: Compelling evidence has demonstrated that Xuebijing (XBJ) exerted protective effects against SIMI. The aims of this study were to investigate whether TLR4/IKKα-mediated NF-κB and JAK2/STAT3 pathways involved in XBJ's cardio-protection during sepsis the mechanisms. Methods: In study, rats randomly assigned three groups: Sham group; CLP XBJ group. Rats treated with or sanitary saline after CLP. Echocardiography, myocardial enzymes HE used detect cardiac function. IL-1β, IL-6 TNF-α...
Sepsis is a clinical syndrome characterized by dysregulated host response to infection, leading life-threatening organ dysfunction. It high-fatality condition associated with complex interplay of immune and inflammatory responses that can cause severe harm vital organs. Sepsis-induced myocardial injury (SIMI), as complication sepsis, significantly affects the prognosis septic patients shortens their survival time. For sake better administrating hospitalized it necessary understand specific...
There is accumulating evidence that decreased histone acetylation involved in normal aging and neurodegenerative diseases. Recently, we found ANP32A, a key component of INHAT (inhibitor acetyltransferases) suppresses acetylation, increased aged cognitively impaired C5 7 mice expressing wild-type human full length tau (htau) transgenic mice. Downregulating ANP32A restored cognitive function synaptic plasticity through upregulation the expressions synaptic-related proteins via increasing...
Information regarding the epidemiology and clinical features of mild to moderate patients caused by COVID-19 in Fangcang Hospital is scarce. Through a retrospective cohort study, characteristics Dongxihu shelter hospitals were analyzed, factors that affected disease progression explored.The 714 with retrospectively analyzed at between February 7 March 8, 2020. We described distribution discharge or transfer times for each patient. According patients, we divided all into Non-Deteriorated...
Mongolian medicine RuXian-I is composed of 30 herbs, which a traditional recipe for clinical treatment breast "Qi Su Bu Ri Le Du Sen" disease (hyperplasia mammary glands, HMG). Based on the previous study, this dissertation further explores therapeutic mechanism estrogen-induced HMG in rats. had no effect body weight and food intake rats toxic effects five organs (heart, lung, spleen, kidney). reduced diameter height nipple, organ index, pathological changes alleviated sex hormone levels oh...