A5101436250- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- ATP Synthase and ATPases Research
- Retinoids in leukemia and cellular processes
- 3D Printing in Biomedical Research
- Nutritional Studies and Diet
- Sulfur Compounds in Biology
- Wnt/β-catenin signaling in development and cancer
- Electrospun Nanofibers in Biomedical Applications
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Colorectal Cancer Treatments and Studies
- Gastrointestinal disorders and treatments
- Tryptophan and brain disorders
- Hydrogen's biological and therapeutic effects
- Medicinal Plants and Bioactive Compounds
- Sodium Intake and Health
- Natural Antidiabetic Agents Studies
- Cholesterol and Lipid Metabolism
- Hydrogels: synthesis, properties, applications
- Curcumin's Biomedical Applications
Hangzhou Medical College
2022-2024
Zhejiang Provincial People's Hospital
2012-2024
Harbin Medical University
2008-2023
Second Affiliated Hospital of Harbin Medical University
2008-2022
Guangxi Medical University
2020
First Affiliated Hospital of GuangXi Medical University
2020
Huazhong University of Science and Technology
2014-2019
Dalian University of Technology
2016-2017
Dalian Institute of Chemical Physics
2016-2017
Chinese Academy of Sciences
2016-2017
Cellular cholesterol levels are tightly regulated and represent a balance of uptake, endogenous synthesis efflux. Although the classic transcriptional regulations metabolism by liver X receptors (LXRs) have been well studied, potential effects LXR‐responsive microRNAs (miRNAs) still need to be unveiled. Here, we describe that miR‐26, an LXR‐suppressed miRNA, inhibits expression ATP‐binding cassette transporter A1 (ABCA1) ADP‐ribosylation factor‐like 7 (ARL7), two LXR target genes which play...
In an attempt to identify the human herpesvirus 7 (HHV-7) envelope protein(s) involved in cell surface binding, extracellular domain of HHV-7 glycoprotein B (gB) homolog protein was cloned and expressed as a fusion product with Fc immunoglobulin G heavy chain gamma1 (gB-Fc) eukaryotic system. Indirect immunofluorescence followed by flow cytometric analysis revealed specific binding gB-Fc membrane SupT1 cells but not other CD4+ T-lymphoblastoid lines, such Jurkat or PM1, clearly indicating...
Abstract Background The discovery of practical biomarkers is important to realize personalized medicine for patients with malignant neoplasias, including colorectal cancer (CRC). Purpose aim this study was determine reliable prognostic by the analysis resectable liver metastases (CRLM). Methods Genomic DNA obtained from CRLM tissues a cohort 126 curative hepatic resection. KRAS / BRAF mutation spectrum and microsatellite instability (MSI) status were successfully analyzed in 100 these...
Abstract Background In the last decade, studies in hepatocellular carcinoma (HCC) demonstrate dysregulation of miRNAs expression. For instance, miR‐650 has been implicated gastric and colorectal cancer tumorigenicity; however, role remains unknown HCC. Methods this study, we performed a comprehensive analysis to examine expression level 248 HCC 120 paracarcinomatous liver (PCL) tissues. The correlations between clinicopathological characteristics (HCC tumorigenicity) were evaluated. played...
Long noncoding RNAs (lncRNAs) have been reported to exhibit a crucial regulatory role in tumor progression, including cholangiocarcinoma (CCA). As promising lncRNA, proteasome 20S subunit alpha 3 antisense RNA 1 (PSMA3-AS1) is involved development of various tumors. However, the and function PSMA3-AS1 CCA remain unclear. The aim this study examine expression, function, mechanism, clinical significance development. By TCGA database analysis, we found that was overexpressed CCA. Consistent...
Hydrogen sulfide (H 2 S) can be synthesized in mammalian cells by cystathionine γ -lyase (CSE) and/or β -synthase (CBS). Both CSE and CBS are expressed rat gastric tissues but their role human neoplasia has been unclear. The aims of the present study were to detect proteins cancer determine effect exogenous NaHS on proliferation cells. We found that both upregulated carcinoma mucosa compared with those noncancerous samples. induced apoptosis regulating related proteins. Also, inhibited cell...
Secreted frizzled-related protein 2, (SFRP2) is a Wnt inhibitor whose promoter CpGs were recently found to be methylated at high frequency in colorectal cancers (CRCs). We hypothesized that the pattern of SFRP2 methylation may differ throughout during progressive tumorigenesis. Using combined bisulfite restriction analysis (COBRA), two methylation-sensitive regions (Regions A and B) investigated 569 specimens tissue:222 CRCs, 103 adenomatous polyps (APs), 208 normal colonic mucosa from CRC...
Abstract Phosphotyrosyl phosphatase activator (PTPA) is decreased in the brains of Alzheimer's disease (AD) and AD transgenic mouse models. Here, we investigated whether down‐regulation PTPA affects cell viability underlying mechanisms. We found that was located integral membrane mitochondria, knockdown induced apoptosis HEK293 N2a lines. mitochondrial potential Bax translocation into mitochondria with a simultaneous release Cyt C, activation caspase‐3, cleavage poly (DNA ribose) polymerase...
Gelatin hydrogel has great potential in regenerative medicine. The degradation of gelatin is important to control the release profile encapsulated biomolecules and regulate vivo tissue repair process. As a plasticizer, PEG can significantly improve mechanical property hydrogel. However, how preparation parameters affect rate gelatin-PEG composite still not clear. In this study, significant effect factor, glutaraldehyde (GA) concentration, was confirmed by means Plackett-Burman method. Then...
Biliary tract cancer (BTC) is a devastating malignancy that notoriously difficult to diagnose and associated with high mortality. Circular RNA (circRNA) class of endogenous non-coding which has been regarded as the key regulator tumor initiation progression, including BTC. nuclear receptor interacting protein 1 (circ_NRIP1), circular RNA, abnormally expressed in many human tumors exhibits diverse functions progression. However, its biological significance BTC not thoroughly investigated. In...
Abstract This study was designed to illustrate the function and role of PCAT1 in CCA. The relative expression confirmed by RT-qPCR western blot. biological evaluated CCK8, EdU, colony formation, wound healing, transwell, subcutaneous tumor formation assays. Protein levels EMT markers were measured binding relationship predicted JASPAR starBase. YY1 promoter assessed ChIP luciferase reporter. capacity between miR-216a-3p as well BCL3 reporter AGO2-RIP In this study, we found that up-regulated...
The objective of this paper was to study the in vitro anti-breast cancer activity polysaccharides from Radix ranunculus ternati. Different concentrations polysaccharide extracts were selected, and MTT assay flow cytometry (FCM) used investigate their growth-inhibitory apoptosis-inducing effects on human breast MCF-7 cell lines. ternati had varying degrees growth lines, differences significant compared with blank control group. FCM showed that can induce apoptosis. In addition, it also...
After islet isolation, diffusion has become the main mechanism to transport oxygen and nutrients into core of islets. However, limitations, by which cannot effectively reach large islets can eventually cause cell death loss. This problem be resolved dispersing single cells, but cells do not exhibit insulin release function in vitro culture. In this study, we intended establish a new engineering approach forming clusters improve survival function. Therefore, alginate gels were used...
Abstract Optimizing alginate gel beads is necessary to support the survival, proliferation, and function of entrapped hepatocytes. In this study, gelling bath was modified by decreasing calcium ion concentration increasing sodium concentration. Alginate (using 36% G alginate) prepared in had more homogeneous structure better mass transfer properties compared with traditional that contains only ions. Moreover, generated could significantly promote HepG2 cell proliferation growth spheroids,...