A5100416475- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
- Pharmacological Effects of Natural Compounds
- Advanced Drug Delivery Systems
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Protein Hydrolysis and Bioactive Peptides
- Nanocomposite Films for Food Packaging
- Chemical Synthesis and Analysis
- Peptidase Inhibition and Analysis
- Cardiac Imaging and Diagnostics
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Lung Cancer Diagnosis and Treatment
- Pharmacogenetics and Drug Metabolism
- Cancer-related molecular mechanisms research
- Neurosurgical Procedures and Complications
- RNA Interference and Gene Delivery
- Fungal Biology and Applications
- Polysaccharides and Plant Cell Walls
- Lung Cancer Treatments and Mutations
- Neuroscience and Neuropharmacology Research
- Sulfur Compounds in Biology
- Radiomics and Machine Learning in Medical Imaging
Zhejiang University
2017-2025
Shanghai University of Traditional Chinese Medicine
2023-2025
Shuguang Hospital
2023-2025
Shandong University
2013-2025
Kunming Medical University
2020-2025
Yangzhou University
2018-2025
Ningxia Medical University
2020-2025
Guangdong Academy of Medical Sciences
2025
Southern Medical University
2025
Guangdong Provincial People's Hospital
2025
Impaired wound healing in diabetics usually leads to life-threatening complications. To develop a system for fastening skin efficiently and safely diabetics, thermos-sensitive hydrogel containing the nanodrug, loaded form of gelatin microspheres (GMs), was designed deliver curcumin (Cur) as therapeutic drug. Cur is naturally existing polyphenolic compound with broad range biological functions useful potential therapies. Because molecule has weakness both bioavailability vivo stability,...
Effective physiological bone integration and absence of bacterial infection are essential for a successful orthopaedic or dental implant.
Invasion and metastasis of solid tumors are the major causes death in cancer patients. Cancer stem cells (CSCs) constitute a small fraction tumor cell population, but play critical role invasion metastasis. The xenograft immunodeficient mice is one commonly used vivo models to study cells. However, this model time-consuming labor intensive. Zebrafish (Danio rerio) their transparent embryos emerging as promising system for studies invasion. In study, we established by using zebrafish embryo...
Colorectal cancer (CRC) is a common malignant tumor that affects people worldwide. Metagenomic analyses have shown an enrichment of Fusobacterium nucleatum (F. nucleatum) in colorectal carcinoma tissue; many studies indicated F. closely related to the carcinogenesis. In this review, we provide latest information reveal molecular mechanisms. The known virulence factors promote adhesion intestinal epithelial cells via FadA and Fap2. Besides, Fap2 also binds immune causing immunosuppression....
Spinal cord injury (SCI) represents a relatively common type of motor system trauma. While the SCI patient will experience varying degrees paraplegia and quadriplegia, which severely affects their quality life, heavy burden is also placed on family society as whole. The exact pathogenic mechanisms underlying this condition remain unknown no specific treatments are currently available. Findings from recent studies have shown that mesenchymal stem cells (MSCs), derived extracellular vesicles...
Loss of CDH1 (E-cadherin) expression in cancer cells may promote cell migration and invasion. Therefore, we hypothesised that loss colorectal carcinoma might be associated with aggressive features clinical outcome. Utilising molecular pathological epidemiology database 689 rectal colon cases the Nurses' Health Study Professionals Follow-up Study, assessed tumour by immunohistochemistry. Multivariate logistic regression analysis was conducted to assess association growth pattern...
Recent studies have reported that Fusobacterium nucleatum (Fn) is associated with gastric cancer (GC). Cancer-derived exosomes contain key regulatory noncoding RNAs and are a crucial medium of intercellular communication. However, the function mechanism (Fn-GCEx) secreted from Fn-infected GC cells remains unclear. In this study, Fn-GCEx enhanced proliferation, migration, invasion capacity in vitro, as well tumor growth metastasis vivo. HOTTIP was also upregulated treated Fn-GCEx. Moreover,...
The Maillard conjugates of cod skin collagen peptide (CSCP) and polydextrose (PDX) were used to stabilize the Antarctic krill oil (AKO) emulsion. First, CSCP–PDX glycoconjugate was prepared using microwave heating (MH) for 20 min, which had a higher grafting rate, wider structure, better functional characteristics than glycoconjugate, by traditional wet-heating (WH) after 10 h. Then, as an emulsifier improved stability AKO emulsion, shown zeta potential, rheology, so forth. In vitro...
It has previously been reported that the influence of vitamin D on metabolism calcium and phosphorus is associated with diabetes, cardiovascular disease, Alzheimer's cancer other systemic diseases, considered an important indicator general health. The present study was conducted to determine effect various doses supplementation glucose metabolism, lipid concentrations, inflammation levels oxidative stress pregnant women gestational diabetes mellitus (GDM). randomized, double-blind...
Glutamate excitotoxicity plays an important role in neuronal death after ischemia. However, all clinical trials using glutamate receptor inhibitors have failed. This may be related to the evidence that activation of different subunit NMDA will induce effects. Many studies shown intrasynaptic NR2A stimulate survival signaling pathways, whereas upregulation extrasynaptic NR2B trigger apoptotic pathways. A Lycium barbarum polysaccharide (LBP) is a mixed compound extracted from fruit. Recent LBP...
Purpose: Spinal cord injury (SCI) is a relatively common, devastating traumatic condition resulting in permanent disability. In this study, the use of exosomes derived from bone mesenchymal stem cells (BMSCs-Exo) as cell-free therapy for treatment SCI rats was investigated to gain insights into their mechanisms action. Methods: Rats were randomly divided three groups, Sham (treated with PBS), (SCI + PBS) and Exo BMSCs-Exo). Changes complement system between groups assessed proteomics. The...