A5065516001- Alzheimer's disease research and treatments
- Gut microbiota and health
- Tryptophan and brain disorders
- Diet and metabolism studies
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Genomics and Rare Diseases
- Drug Transport and Resistance Mechanisms
- Cholesterol and Lipid Metabolism
- Immune cells in cancer
- Metabolomics and Mass Spectrometry Studies
- Nuclear Receptors and Signaling
- Sleep and Wakefulness Research
- Natural product bioactivities and synthesis
- Neuropeptides and Animal Physiology
- Advanced MRI Techniques and Applications
- Cell Adhesion Molecules Research
- Biochemical effects in animals
- Inflammatory Bowel Disease
- Pulmonary Hypertension Research and Treatments
- Hippo pathway signaling and YAP/TAZ
- Vagus Nerve Stimulation Research
- Cytokine Signaling Pathways and Interactions
- Histone Deacetylase Inhibitors Research
- Bioinformatics and Genomic Networks
Shanghai Jiao Tong University
2020-2024
Ruijin Hospital
2020-2024
Jiangnan University
2018-2019
Acute lung injury (ALI) is a severe clinical disease marked by dysregulated inflammation response and has high rate of morbidity mortality. Macrophages, which play diverse roles in the inflammatory response, are becoming therapeutic targets ALI. In this study we investigated effects dehydrocostus lactone (DHL), natural sesquiterpene, on macrophage activation LPS-induced The cell line RAW264.7 primary macrophages were incubated with DHL (0, 3, 5, 10 30 μmol/L) for 0.5 h then challenged LPS...
Numerous studies have described the notable impact of gut microbiota on brain in Alzheimer's disease (AD) via – axis. However, molecular mechanisms underlying involvement development AD are limited. This study aimed to explore potential by integrating multi-omics data. In this study, APP/PS1 and WT mice at nine months age were used as mouse model. Cognitive function was assessed using Morris water maze test. The levels Aβ plaque neuroinflammation detected immunofluorescence PET/CT. addition,...
Alzheimer's disease (AD) is the most common neurodegenerative and its pathogenesis still unclear. There dysbiosis of gut microbiota in AD patients. More importantly, has been observed not only patients, but also patients with mild cognitive impairment (MCI). However, mechanism poorly understood. Cholinergic anti-inflammatory pathway an important for central nervous system (CNS) regulation peripheral immune homeostasis, especially gut. Therefore, we speculated that dysfunction cholinergic a...
There are many metabolic pathway abnormalities in Alzheimer's disease (AD). Several studies have linked branched-chain amino acid (BCAA) metabolism disorders with AD but not obtained consistent results. The purpose of this study is to explore the causal association between BCAA concentration and risk AD.A bidirectional Mendelian randomized (MR) was applied effect level AD. Genetic instrumental variables from genome-wide (GWAS) serum levels [total BCAAs (115,047 participants), valine (115,048...
Immune system dysfunction has been proven to be an important pathological event in Alzheimer's disease (AD). Mild cognitive impairment (MCI), as a transitional stage between normal function and AD, was research object for the screening of early diagnostic markers therapeutic targets AD. However, systematic assessment peripheral immune changes MCI patients consistent analysis with that CNS were still lacking.Peripheral blood transcriptome data from AddNeuroMed Cohort (n = 711) used training...
Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder frequently accompanied by cognitive impairment. Contributing factors such as modern lifestyle, genetic predisposition, and gene environmental interactions have been postulated, but the pathogenesis remains unclear. In this study, we attempt to investigate potential mechanisms interventions underlying T2DM-induced deficits from brain–gut axis perspective. A combined analysis of brain transcriptome, plasma metabolome, gut...
ABSTRACT Background Paroxysmal kinesigenic dyskinesia (PKD) is the most common type of paroxysmal dyskinesias. Only one‐third PKD patients are attributed to proline‐rich transmembrane protein 2 ( PRRT2 ) mutations. Objective We aimed explore potential causative gene for PKD. Methods A cohort 196 ‐negative probands were enrolled whole‐exome sequencing (WES). Gene Ranking, Identification and Prediction Tool, a method case–control analysis, was applied identify candidate genes. Another 325...
Abstract Purpose Despite the revealed role of immunological dysfunctions in development and progression Alzheimer’s disease (AD) through animal postmortem investigations, direct evidence regarding impact genetic factors on microglia response amyloid-β (Aβ) deposition AD individuals is lacking. This study aims to elucidate this mechanism by integrating transcriptomics TSPO, Aβ PET imaging clinical cohort. Methods We analyzed 85 patients with PET/MR for microglial activation (TSPO, [ 18...
Alzheimer's disease (AD) is a devastating in the elderly with no known effective treatment. It characterized by progressive deterioration of memory and cognition. Many new potential targets are being investigated to develop therapeutic strategies for AD. Neuropeptide S (NPS) an endogenous peptide central nervous system, which has been shown play beneficial role learning memory. However, whether NPS can ameliorate cognitive deficits AD remains unclear. In this study, we examined effects...
Abstract INTRODUCTION Altered neurometabolism, detectable via proton magnetic resonance spectroscopic imaging ( 1 H‐MRSI), is spatially heterogeneous and underpins cognitive impairments in Alzheimer's disease (AD). However, the spatial relationships between neurometabolic topography impairment AD remain unexplored due to technical limitations. METHODS We used a novel whole‐brain high‐resolution H‐MRSI technique, with simultaneously acquired 18 F‐florbetapir positron emission tomography (PET)...
Alzheimer's disease (AD) is the most common type of neurodegenerative disease. Tau pathology one pathological features AD, and its progression closely related to progress AD. Immune system dysfunction an important mediator progression, but specific molecular mechanism still unclear. The purpose this study determine immune hub genes peripheral cell infiltration associated with Braak stages, mechanisms between them.In study, 60 samples different stages in GSE106241 dataset were used screen...
There is accumulating evidence that decreased histone acetylation involved in normal aging and neurodegenerative diseases. Recently, we found ANP32A, a key component of INHAT (inhibitor acetyltransferases) suppresses acetylation, increased aged cognitively impaired C5 7 mice expressing wild-type human full length tau (htau) transgenic mice. Downregulating ANP32A restored cognitive function synaptic plasticity through upregulation the expressions synaptic-related proteins via increasing...
Occipital cortical malformation (OCCM) is a disease caused by malformations of development characterized polymicrogyria and pachygyria the occipital lobes childhood-onset seizures. The recessive or complex heterozygous variants LAMC3 gene are identified as cause OCCM. In present study, we novel (c.470G > A c.4030 + 1G A) in Chinese female with Cranial magnetic resonance imaging was normal. Functional experiments confirmed that both variant sites premature truncation laminin γ3 chain....
Background: Cerebrotendinous xanthomatosis(CTX) is an autosomal recessive disorder of bile acid synthesis caused by mutations in the CYP27A1 gene. CTX underdiagnosed and potentially treatable disease, thus a detailed appreciation phenotypic spectrum genetic characteristics are crucial for early diagnosis treatment. Objectives methods: Four families with gene were enrolled our study. We investigated clinical molecular features probands CTX. Genetic analysis was performed detecting variants....
Summary It has been established that lanatoside C, a FDA ‐approved cardiac glycoside, reduces proliferation of cancer cell lines. The fibroblasts is critical to the pathogenesis pulmonary fibrosis ( PF ), progressive and fatal fibrotic lung disease lacking effective treatment. In this study we have investigated impact C on bleomycin BLM )‐induced mouse model through evaluation fibroblast activation in vitro. We evaluated explanted tissue by histological staining, western blot analysis, qRT ‐...
Parkinson's disease (PD) is the second most common neurodegenerative disorder, and mechanism of its occurrence still not fully elucidated. Accumulating evidence has suggested that gut acts as a potential origin PD pathogenesis. Recent studies have identified inflammatory bowel risk factor for disease, although underlying mechanisms remain elusive. The aim this study was to further explore molecular between Crohn's (CD). gene expression profiles (GSE6613) CD (GSE119600) were downloaded from...