Abstract Objective This study aims to investigate the relationship between obesity and constipation among American adults. Methods Our leveraged data from National Health Nutrition Examination Survey (NHANES). comprehensive approach enabled us summarize weighted prevalence rates of in To further deepen our understanding, we employed a variety analytical methods. These included multivariable logistic regression, subgroup analysis restricted cubic splines. Through these methodologies, were...

Many studies have reported the important role of glucagon-like peptide-1 receptor (GLP-1R) in regulating glucose homeostasis. However, addition to pancreas, GLP-1R is distributed organs such as lungs. A few researches mechanism action acute and chronic lung diseases. Nevertheless, its effect on development remains unclear. In this research, we aimed explore potential mechanisms vivo vitro bronchopulmonary dysplasia (BPD) models. Neonatal Sprague-Dawley rats were divided into hyperoxia (FIO2...

Background and Purpose Mitochondrial dysregulation of endothelial progenitor cells (EPCs) has been implicated in destruction hypertension. Regulation silent information regulator 3 (sirtuin 3; SIRT3) mitochondrial damage EPCs the underlying molecular mechanisms remain unclear, evidence selective SIRT3 agonists for treatment hypertension also is lacking. Experimental Approach Here, we discovered a potent agonist, rhynchophylline (Rhy), explored its action on dysfunction. Key Results In...

Hepatitis B virus X protein (HBx) is a multifunctional protein, and it activates multiple signal transduction pathways in types of cells regulates the process cell apoptosis. In present study, we mainly investigated correlation between HBx renal tubular epithelial apoptosis hepatitis virus-associated glomerulonephritis (HBVGN) possible signaling mechanism. Cell nephridial tissues patients with HBVGN were determined by TUNEL method. HBx, p-STAT3 STAT3 levels immunohistochemical assay,...

Abstract Background and Aim Drug therapy is the treatment of choice for Crohn's disease because it effectively controls or prevents intestinal inflammation. The purpose was to research molecular mechanism total flavones Abelmoschus manihot (TFA) on fibrosis in disease. Methods A 2,4,6‐Trinitrobenzenesulfonic acid (TNBS)‐induced colitis model IGF‐1‐treated fibroblasts were established. Then, TFA, 3‐MA, compound C used treatments. Hematoxylin eosin, Masson, Picrosirius red staining performed...

Is allograft inflammatory factor-1 (AIF-1), a cytokine associated with inflammation and rejection, aberrantly elevated in vitro fertilization (IVF) cycles gonadotropin-releasing hormone (GnRH) antagonist protocol potential effects on endometrial receptivity?

The fruit (aril) of the endangered genus Taxus plants is an abandoned herbal resource. Traditionally, people enthusiastically focus on its bark, renewable, tremendous arils fall into soil with seeds after they are mature. present research investigated two species from , chinensis var. mairei and media regards to their antioxidant antihyperglycaemic activities, safety, bioactive constituents. Results showed that T . both had certain biological activities better in activity activity....

Abstract Aim Autophagy is a common process during development. Abnormal autophagy can impact cell apoptosis. Previous studies have shown that apoptosis present bronchopulmonary dysplasia (BPD). However, there no consensus on the level of coexisting autophagy. This study was designed to investigate role and effects inducers in BPD model. Method A total 100 newborn Sprague‐Dawley rats were randomly assigned model control groups. models established by hyperoxic induction(FiO 2 0.80). Some them...

Pharmacy is the last department for outpatient in hospital, efficiency of which directly associated with patient satisfaction and reputation entire hospital. The aim study to improve queuing system pharmacy based on simulation method. After stimulating suitable models current situation, then changes number queues have been made see if there any improvement efficiency. Results showed that single-queue multi-window pattern not only much more balanced assign prescriptions each window, but also...

Protocatechuic aldehyde (PCA) is a natural phenolic acid compound with pharmacological effects such as anti-oxidative stress, antibacterial, anti-apoptotic, anti-inflammatory, anti-platelet aggregation, and anti-tumor. Despite the favorable therapeutic of PCA, it imperative to recognize that adverse drug reactions can arise even satisfactory quality assurance measures during standard clinical application dosing. Additionally, acute toxicity cardiotoxic sequelae PCA are frequently under...

Effects of dexmedetomidine (Dex) on oxidative stress and inflammatory response in lungs during mechanical ventilation chronic obstructive pulmonary disease (COPD) rats were investigated. Eleven out 38 SD randomly selected as the blank control group, other 27 subjected to modeling. After modeling, 11 group from model received non-invasive test for lung function. Three 3 hematoxylin eosin (HE) staining confirm successful 24 divided into groups, 8 each including control, Dex low-dose high-dose...

The objective of this research was to study the effect tong bian decoction on colon transport function interstitial cells Cajal (ICC) in chronic transit constipation (CTC) and inhibition autophagy ICC, so as achieve free movement bowels. In research, experimental rats were divided into normal group (NG) model (MG) by random method, rat CTC constructed subdivision circulatory increasing operation gavage method rhubarb. After successful establishment model, group, MG, mosapride recovery group....

Autophagy is closely associated with atherosclerosis and other cardiovascular diseases (CVD). Compound Danshen prescription widely used as a clinical antiatherosclerotic drug. In our previous studies, we have shown that the combined active component, ginsenoside Rg1-notoginsenoside R1-protocatechualdehyde (RRP), can effectively alleviate endothelial dysfunction reduce atherosclerotic plaques. However, association between cellular senescence, caused by reduced autophagy, remains unclear. this...

Abstract Background Bronchopulmonary dysplasia (BPD) is the most common and serious chronic lung disease in preterm infants with pathological characteristics of arrested development. DNA double-strand breaks (DSBs) are a manifestation oxidative stress damage, but little known about role DSBs BPD. The current study set out to detect DSB accumulation cell cycle arrest BPD expression genes related damage repair through signaling pathway-based PCR array determine suitable target improve...

Abstract Details of a biogenetically inspired strategy that led to the synthesis hetidine‐type C 20 ‐diterpenoid alkaloid skeleton are reported in this paper. Key steps our include C—H oxidation convert atisine‐type core ajaconine skeleton, as well an aza ‐Prins cyclization establishes hetidine skeleton. An unexpected heptacyclic framework bearing unique tricyclo[3.3.1.0 2,7 ]nonane moiety has been obtained during studies, which may represent new type alkaloids yet be discovered.

The occurrence and development of an endemic OA, Kashin-Beck disease (KBD), is closely related to oxidative stress induced by free radicals. aim the study was find key signalling molecules or pathogenic factors as a potential treatment strategy for KBD.