A5100751690- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Phytochemicals and Antioxidant Activities
- Metabolism, Diabetes, and Cancer
- Phytochemistry and Biological Activities
- Renal and related cancers
- Natural product bioactivities and synthesis
- Pluripotent Stem Cells Research
- Lipid metabolism and biosynthesis
- Bee Products Chemical Analysis
- Tea Polyphenols and Effects
- Medicinal Plants and Bioactive Compounds
- CRISPR and Genetic Engineering
- Polysaccharides and Plant Cell Walls
- Reproductive Biology and Fertility
- Essential Oils and Antimicrobial Activity
- Liver physiology and pathology
- Bioenergy crop production and management
- Chromatography in Natural Products
- Hereditary Neurological Disorders
- Ginger and Zingiberaceae research
- Ginkgo biloba and Cashew Applications
- Hippo pathway signaling and YAP/TAZ
- Neurological diseases and metabolism
- Diet and metabolism studies
Chongqing University
2025
Chongqing Medical University
2015-2024
Guizhou Institute of Plant Protection
2024
Xijing Hospital
2024
China Agricultural University
2017
Background: Hepatic fibrosis is a major global health issue without an optimal drug treatment, highlighting the urgent need to find effective therapies. This study aimed clarify role and mechanism of micheliolide in treating hepatic fibrosis. Methods: The efficacy MCL was evaluated mouse model CCl4-induced LX-2 cells were subjected subsequent changes markers, autophagy, MEK/ERK pathway analyzed using transcriptomics Western blotting. interaction between TrxR1 or TrxR2 validated cellular...
Scope: Hawk tea, a non-Camellia is an ancient tea drink from southwest China and has been proven to exhibit significant hypoglycaemic lipid-lowering effects. The aim of this study was evaluate whether extract (HTE) can improve obesity induced by high-fat diet (HFD) in mouse model determine its anti-obesity effects are related improvements lipid metabolism the gut microbiota. Methods results: We tested ability HTE prevent regulate microbiota C57BL/6J mice fed with HFD. found that...
In this study, volatile oils of six Hawk tea varieties were studied for their chemical composition, antioxidant and antimicrobial activities to screen the most suitable botanical origins tea. A total 72 components separated identified from oils. The major constituents were: α ‐pinene, camphene, limonene, 1,8‐cineole, linalool, cis ‐nerolidol, germacrene B. Moreover, evaluated potential activities. results showed that all exhibited acceptable activities, which suggested these may serve as...
This study investigates the dual actions of 6-gingerol in stimulating both plasma adiponectin and muscular receptor signaling naturally ageing rats.Twenty-two-month-old male SD rats were treated with (0.2 mg kg-1 , once daily) for 7 weeks. 6-Gingerol can attenuate age-associated high triglyceride, glucose, insulin concentrations under fasting conditions as well suppress increase HOMA-IR index inhibit decrease p-Akt/Akt protein rats, which indicates an improvement systemic sensitivity....
The fruit (aril) of the endangered genus Taxus plants is an abandoned herbal resource. Traditionally, people enthusiastically focus on its bark, renewable, tremendous arils fall into soil with seeds after they are mature. present research investigated two species from , chinensis var. mairei and media regards to their antioxidant antihyperglycaemic activities, safety, bioactive constituents. Results showed that T . both had certain biological activities better in activity activity....
Incarvillea compacta Maxim is a traditional Tibetan plant widely used to treat rheumatic pain and bruises. We conducted qualitative analyses by liquid chromatography-mass spectrometry quantitative of the total phenols, flavonoids, alkaloids content different extracts I. Maxim. Antioxidant analgesic activity were analyzed. The results showed that methanol extract had highest various ingredients. A 25 constituents identified, which compounds 1–23 found for first time in this plant. water...
Analytical method of PAHs in TCMs based on different medicinal parts, levels, distribution, and sources.
Hawk tea is a rich and edible resource, traditionally used as beverage in South China. This drink has many pharmacologic effects, such acting an antioxidant reducing blood sugar lipids. The objective of this work was to explore the active compound contents, bioactivities their monthly changes, optimize harvest time. In present study, from each month 2017 collected extracted with 70% (v/v) ethanol. contents total flavonoids phenols were determined using colorimetric method. We seven...
Activated hepatic stellate cells (HSCs) are the principal effectors during fibrosis, which is characterized by accumulation of extracellular matrix. Therefore, present therapies and investigations into fibrosis mainly focus on suppression activated HSCs. Astragaloside IV (ASIV) an effective constituent extracted from plant Astragalus membranaceus has exhibited anti-fibrotic properties in fibrosis. However, its protective mechanism against not fully understood. The study aimed to investigate...
Abstract Tubular injury and oxidative stress are involved in the pathogenesis of diabetic kidney disease (DKD). Astragaloside IV (ASIV) is a natural antioxidant. The effects underlying molecular mechanisms ASIV on DKD have not been elucidated. db/db mice high‐glucose‐stimulated HK2 cells were used to evaluate beneficial vivo vitro. Succinylated proteomics was identify novel against experimentally further validated. alleviated renal dysfunction proteinuria, downregulated fasting blood...
The mechanisms of oleanolic acid (OA) regulating hepatic sterol regulatory element-binding protein (SREBP) 1c/stearoyl-CoA desaturase (SCD) 1 pathway to ameliorate fructose-induced hepatosteatosis are investigated.Rats treated with 10% w/v fructose solution co-administered by OA for 5 weeks, and then sacrifice after fasting 14 h. reverses the increase in triglyceride (TG) content downregulates Scd1 mRNA expression. However, two upstream transcription factors, ChREBP SREBP1c, remain at normal...
Rhodiola species have been used for asthenia, depression, fatigue, poor work performance and cardiovascular diseases, all of which may be associated with insulin resistance. To disclose the underlying mechanisms action, effect crenulata root (RCR) on resistance was investigated. Male Sprague-Dawley rats were treated liquid fructose in their drinking water over 18 weeks. The extract RCR co-administered (once daily by oral gavage) during last 5 indexes lipid glucose homeostasis determined...
Increasing evidence has shown the beneficial effects of Rhodiola species on metabolic disorders, but their mechanisms are not clear. Hepatic steatosis is closely related to we aim investigate therapeutic crenulata root (RCR) fructose-induced hepatic and explore underlying mechanisms. To observe effect extract in Sprague-Dawley (SD) rats its possible mechanism. Male were treated with liquid fructose drinking water over 18 weeks. The RCR was co-administered (once daily by oral gavage) during...
Humulus scanden, rich in flavonoids, is a traditional Chinese medicine. It widely used China to treat tuberculosis, dysentery and chronic colitis. In this study, scandens (H.S) was extracted different solvents (water, n-butanol, acetic ether chloroform) the antioxidant, anti-inflammatory activities of extracts were investigated by four assays including DPPH, reducing power, xylene-induced mouse ear edema cotton pellet-induced granuloma methods. And then, acute oral toxicity biochemical...
Apple pomace and rosemary (AR) have been reported to contain rich bioactive molecules, which numerous metabolic effects. Our preliminary work revealed that AR ameliorated fructose‑induced insulin resistance in rats by modulating sarcolemmal CD36 glucose transporter‑4. The present study aimed further examine how improves disorders investigating the effect of on hepatic steatosis induced fructose overconsumption. results demonstrated (100 mg/kg daily gavage for 5 weeks) attenuated chronic...
Ageing often results in insulin resistance (IR) and chronic inflammation, adipose is one of the tissues which inflammation IR occur earliest during this process. The present study investigated effect underlying mechanisms ursolic acid (UA) on ageing rats. Specific pathogen-free male Sprague-Dawley rats were randomly divided into 4 groups: i) Young normal (young); ii) untreated (aged); groups supplemented with UA either iii) low-UA 10 mg/kg (UA-L) or iv) high-50 (UA-H). Animals UA-treated...