A5100405077- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Pluripotent Stem Cells Research
- FOXO transcription factor regulation
- Cancer, Hypoxia, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Cytomegalovirus and herpesvirus research
- Extracellular vesicles in disease
- Liver Diseases and Immunity
- Biological Activity of Diterpenoids and Biflavonoids
- Reproductive System and Pregnancy
- Nuclear Structure and Function
- Environmental Toxicology and Ecotoxicology
- Organ Transplantation Techniques and Outcomes
- Cardiovascular Disease and Adiposity
- Muscle Physiology and Disorders
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- Reproductive Biology and Fertility
Qingdao Agricultural University
2025
Chongqing Medical University
2024
Qiqihar Medical University
2022
Army Medical University
2019-2021
Southwest Hospital
2019-2021
Institute of Modern Physics
2014
Chinese Academy of Sciences
2014
Mitochondria are key regulators of hematopoietic stem cell (HSC) homeostasis. Our research identifies the transcription factor Nynrin as a crucial regulator HSC maintenance by modulating mitochondrial function. is highly expressed in HSCs under both steady-state and stress conditions. The knockout diminishes frequency, dormancy, self-renewal, with increased dysfunction indicated abnormal mPTP opening, swelling, elevated ROS levels. These changes reduce radiation tolerance promote...
The oncogene DEK is found fused with the NUP214 gene creating oncoprotein DEK-NUP214 that induces acute myeloid leukemia (AML) in patients, and secreted protein functions as a hematopoietic cytokine to regulate hematopoiesis; however, intrinsic role of nuclear stem cells (HSCs) remains largely unknown. Here, we show HSCs lacking display defects long-term self-renew capacity, eventually resulting impaired hematopoiesis. deficiency reduces quiescence accelerates mitochondrial metabolism HSCs,...
Abstract The dose-response relationship between toxicants and organisms is the most fundamental principle in toxicological risk assessment. However, multiphasic non-linear responses are poorly understood underlying mechanisms remain elusive. In this study, we subjected indicator plant Tillandsia usneoides to 5 or 10 time gradients of 1 mM Pb, assessed response patterns five damage markers eight resistance leaves. results showed that assay with gradients, out 13 biomarkers biphasic 2...
Abstract Forkhead box M1 (FoxM1) transcriptional factor has a principal role in regulating cell proliferation, self-renewal, and tumorigenesis. However, whether FoxM1 regulates endogenous muscle development regeneration remains unclear. Here we found that loss of satellite cells (SCs) resulted atrophy defective regeneration. functioned as direct transcription activator adenomatous polyposis coli (Apc), preventing hyperactivation wnt/β-catenin signaling during overexpression SCs promoted...
Activated hepatic stellate cells (HSCs) are the principal effectors during fibrosis, which is characterized by accumulation of extracellular matrix. Therefore, present therapies and investigations into fibrosis mainly focus on suppression activated HSCs. Astragaloside IV (ASIV) an effective constituent extracted from plant Astragalus membranaceus has exhibited anti-fibrotic properties in fibrosis. However, its protective mechanism against not fully understood. The study aimed to investigate...
Radiotherapy has been focused mainly on killing cancer cells, and little attention paid to the process supporting tumor growth metastasis, including of angiogenesis. To investigate effects carbon-ion irradiation angiogenesis in lung we examined expression vascular endothelial factor basic fibroblast conditioned medium (TCM) A549 cells exposed or X-ray irradiation, as well cell growth, invasion, tube formation induced by TCM. No changes secretion were detected TCM at 2 4 Gy, whereas 1 Gy...
Zinc finger protein 521 (Zfp521), a quiescent hematopoietic stem cell (HSC)-enriched transcription factor, is involved in the self-renewal and differentiation of fetal liver HSC. However, its role adult hematopoiesis remains elusive. Here, we found that Zfp521 deletion did not inhibit under homeostatic conditions. In contrast, Zfp521-null chimeric mice showed significantly reduced pool size HSC progenitor cells associated with increased apoptosis loss quiescence. Competitive serial...