A5100377201- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Head and Neck Cancer Studies
- Thyroid Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Ear and Head Tumors
- Gut microbiota and health
- Dementia and Cognitive Impairment Research
- Calcium signaling and nucleotide metabolism
- Sirtuins and Resveratrol in Medicine
- Sexual function and dysfunction studies
- Phagocytosis and Immune Regulation
- Diabetes Treatment and Management
- TGF-β signaling in diseases
- Chronic Kidney Disease and Diabetes
- Neuroendocrine Tumor Research Advances
- Diet and metabolism studies
- Particle physics theoretical and experimental studies
- Dark Matter and Cosmic Phenomena
- Glioma Diagnosis and Treatment
- Adipose Tissue and Metabolism
First Affiliated Hospital Zhejiang University
2025
Shandong University
2025
Institute of High Energy Physics
2025
University of Chinese Academy of Sciences
2024-2025
National Heart Centre Singapore
2024
Fudan University
2010-2024
Huashan Hospital
2010-2024
Eye & ENT Hospital of Fudan University
2024
Hefei Normal University
2024
Tianjin Medical University
2023
In this Letter, we report the dark matter search results from commissioning run (Run0) and first science (Run1) of PandaX-4T experiment. The two datasets were processed with a unified procedure, Run1 data treated blindly. processing is improved compared to previous work, unifying low-level signal reconstruction in wide energy range up 120 keV. With total exposure 1.54 tonne·year, no significant excess nuclear recoil events found. lowest 90% confidence level exclusion on spin-independent...
New particles beyond the standard model of particle physics, such as axions, can be effectively searched through their interactions with electrons. We use large liquid xenon detector PandaX-4T to search for novel electronic recoil signals induced by solar neutrinos anomalous magnetic moment, axionlike particles, dark photons, and light fermionic matter. A detailed background is established using latest datasets <a:math xmlns:a="http://www.w3.org/1998/Math/MathML"...
Dysbiosis of gut microbiota is associated not only with intestinal disorders but also numerous extraintestinal diseases. Growth hormone-secreting pituitary adenoma (GHPA) an insidious disease persistent hypersecretion GH and IGF-1, causing increased morbidity mortality.
Abstract Objective To compare an autoregressive integrated moving average (ARIMA) model with a that combines ARIMA the Elman recurrent neural network (ARIMA-ERNN) in predicting incidence of pertussis mainland China. Background The has increased rapidly China since 2016, making disease increasing public health threat. There is pressing need for models capable accurately order to guide prevention and control measures. We developed compared two Methods Data on from 2004 2019 were obtained...
Abstract As an important part of tumor microenvironment, neutrophils are poorly understood due to their spatiotemporal heterogeneity in tumorigenesis. Here we defined, at single-cell resolution, CD44 −CXCR2 − as tumor-specific (tsNeus) both mouse and human gastric cancer (GC). We uncovered a Hippo regulon with unique YAP signature genes (e.g., ICAM1, CD14, EGR1) distinct from those identified epithelial and/or cells. Importantly, knockout YAP/TAZ neutrophiles impaired differentiation into...
Objective To investigate the association between anemia and progression of diabetic kidney disease (DKD) in type 2 diabetes. Methods This was a retrospective study. A total 2570 in-patients with diabetes hospitalized Jinan branch Huashan hospital from January 2013 to October 2017 were included, among whom 526 patients ≥ times median follow-up period 2.75 years. Annual rate eGFR decline calculated multiple admissions. exceeding -5 ml/min per 1.73 m year defined as rapid decline. The...
This study examined the effects of a multicomponent intervention program on cognitive function in community-dwelling older adults with mild impairment (MCI) and subjective decline (SCD).
Macrophages play a central role in antitumor immunity, making them an attractive target for gene therapy strategies. However, macrophages are difficult to transfect because of nucleic acid sensors that can trigger the degradation foreign plasmid DNA. Here, we developed macrophage-specific editing (MAGE) system by which compact DNA encoding CasRx editor be delivered poly(β-amino ester) (PBAE) carrier bypass sensor and enable RNA vitro vivo. We identified four-arm branched PBAE with...
Spironolactone (SPR) has been shown to protect diabetic cardiomyopathy (DCM), but the specific mechanisms are not fully understood. Here, we determined cardioprotective role of SPR in mice and further explored potential both vivo vitro models. Streptozotocin- (STZ-) induced rats were used as model. After onset diabetes, treated with either (STZ + SPR) or saline NS) for 12 weeks; nondiabetic controls (NDCs). In vitro, H9C2 cells exposed aldosterone, without SPR. Cardiac structure was...
Abstract Obesity is caused by an imbalance between calorie intake and energy expenditure, leading to excessive adipose tissue accumulation. Nicotinamide adenine dinucleotide (NAD + ) important molecule in signal transduction, NAD supplementation therapy a new treatment for obesity recent years. Liver kinase B1 (LKB1) metabolism regulator. The relationship LKB1 has only been studied the heart not yet reported obesity. mononucleotide (NMN), as direct precursor of , can effectively enhance...
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is an emerging major unmet need and one of the most significant clinic challenges in cardiology. The pathogenesis HFpEF associated multiple risk factors. Hypertension metabolic disorders obesity are 2 prominent comorbidities observed patients HFpEF. Although hypertension-induced mechanical overload has long been recognized as a potent contributor to heart reduced fraction, synergistic interaction between remains poorly...
Abstract Due to the substantial limitation of study population, Spindle cell sarcoma (SCS) was unexplored comprehensively. In this study, we investigated clinical characteristics and disease specific prognostic factors SCS. 3299 SCS cases were identified extracted from Surveillance, Epidemiology, End Results (SEER) database (1973–2017). White people account for 79.1% with median age 57 years without predominance in any gender. Significant survival (DSS) overall (OS) found differentiated age,...
Objective: To study the sonographic features of primary site papillary thyroid microcarcinoma (PTMC) for prediction cervical lymph node metastasis during preoperative diagnosis. Methods: A total 710 PTMC patients between 2013 and 2016 with a diagnosis metastases were reviewed. We analyzed to predict ipsilateral or central in univariate multivariate models. The ratio abutment/perimeter was utilized evaluate status. Results: Regarding clinical characteristics, multifocality extrathyroidal...
The expression of somatostatin receptor subtypes (SSTRs) in pituitary growth hormone- (GH-) secreting adenomas may predict the response to analogues (SSA). Our aim was evaluate value immunohistochemical (IHC) scores 2 subtypes, SSTR2 and SSTR5, predicting short-term efficacy SSA therapy patients with active acromegaly. Ninety-three newly diagnosed acromegalic were included our study. These categorized into either a SSA-pretreated group (SA, n = 63) or direct-surgery (DS, 30), depending on...
BACKGROUND The restoration of sensory and motor function in brachial plexus root avulsion patients is a difficult challenge. central nervous system plays an important role recovery after peripheral nerve injury repair. OBJECTIVE To investigate the process surgery at cortical level rodent models with contralateral C7 transfer. METHODS Thirty-five male Sprague-Dawley rats were used this experiment, both behavioral tests somatosensory evoked potentials to injured forepaws reorganization...
We analysed endothelial function and oxidative stress in patients with abnormal glucose metabolism, the effect of load, impact nateglinide. 109 participants were grouped into newly diagnosed diabetes, prediabetes, control. Fasting plasma (FPG), postprandial (PPG), glycosylated haemoglobin (HbA1c), glycated albumin (GA) varied significantly among study groups (P < 0.01). Nitric oxide (NO) insulin resistance index (HOMA-IRI) levels markedly different between diabetes control Glucose loading...
Dementia has become a public health priority and is irreversible. Mild cognitive impairment (MCI), an intermediate state between normal cognition dementia, the prime time for early diagnosis intervention. The activities of daily living dementia patients are usually insufficient. Therefore, continuing to explore risk factors MCI, especially influence physical activity on MCI its mechanism can enrich relevant research fields in China.For this cross-sectional study, 2,518 adults aged 60 years...