A5100321593- Molecular Sensors and Ion Detection
- Sulfur Compounds in Biology
- Folate and B Vitamins Research
- Luminescence and Fluorescent Materials
- Dark Matter and Cosmic Phenomena
- Advanced biosensing and bioanalysis techniques
- Genomic variations and chromosomal abnormalities
- Nitric Oxide and Endothelin Effects
- Biosensors and Analytical Detection
- Nanoplatforms for cancer theranostics
- Sulfur-Based Synthesis Techniques
- Atomic and Subatomic Physics Research
- Peptidase Inhibition and Analysis
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Glycation End Products research
- Particle physics theoretical and experimental studies
- Liver Disease Diagnosis and Treatment
- Electrochemical sensors and biosensors
- Nanomaterials for catalytic reactions
- Cancer-related molecular mechanisms research
- Catalytic Processes in Materials Science
- Catalysts for Methane Reforming
- Advanced Nanomaterials in Catalysis
- Catalytic Cross-Coupling Reactions
- Congenital heart defects research
Henan University
2017-2025
Shanghai Jiao Tong University
2021-2025
National Center for Drug Screening
2025
Shanghai Institute of Materia Medica
2025
Northwest A&F University
2023-2024
West China Second University Hospital of Sichuan University
2019-2024
Sichuan University
2018-2024
Nanjing University of Chinese Medicine
2024
China Pharmaceutical University
2024
National Medical Products Administration
2024
Hepatic lipid droplets (LDs) and peroxynitrite (ONOO-) levels are closely related to nonalcoholic fatty liver disease (NAFLD). Additionally, some drug-induced injury (DILI) is often associated with ONOO-. Here, we constructed screened the quasi-LDs-targeted ONOO--responsive fluorescent probe MBDP-Py+ investigate interaction of NAFLD DILI. By monitoring upregulation ONOO- accumulation LDs, was more sensitive efficient than tissue staining serum markers detection in evaluating early toxicity...
Hydrogen sulfide (H2S) is a significant component of various physiological processes, and it can also cause negative effect on foodstuffs. In this work, we designed synthesized an NIR fluorescent turn-on responding probe (DDM-H2S) with large Stokes shift (190 nm) for the detection H2S. DDM-H2S exhibited high selectivity sensitivity, obvious color changes, fast response time tracing When reacted H2S, PET process was eliminated, recovered ICT fluorescence were observed. Moreover, could image...
The PandaX-4T liquid xenon detector at the China Jinping Underground Laboratory is used to measure solar <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" display="inline"><a:mrow><a:mmultiscripts><a:mrow><a:mi mathvariant="normal">B</a:mi></a:mrow><a:mprescripts/><a:none/><a:mrow><a:mn>8</a:mn></a:mrow></a:mmultiscripts></a:mrow></a:math> neutrino flux by detecting neutrinos through coherent scattering with nuclei. Data samples requiring coincidence of scintillation and ionization...
In this Letter, we report the dark matter search results from commissioning run (Run0) and first science (Run1) of PandaX-4T experiment. The two datasets were processed with a unified procedure, Run1 data treated blindly. processing is improved compared to previous work, unifying low-level signal reconstruction in wide energy range up 120 keV. With total exposure 1.54 tonne·year, no significant excess nuclear recoil events found. lowest 90% confidence level exclusion on spin-independent...
New particles beyond the standard model of particle physics, such as axions, can be effectively searched through their interactions with electrons. We use large liquid xenon detector PandaX-4T to search for novel electronic recoil signals induced by solar neutrinos anomalous magnetic moment, axionlike particles, dark photons, and light fermionic matter. A detailed background is established using latest datasets <a:math xmlns:a="http://www.w3.org/1998/Math/MathML"...
Lung adenocarcinoma (LUAD) is a highly prevalent malignancy worldwide, and its clinical prognosis assessment treatment major research direction. Both ferroptosis cuproptosis are novel forms of cell death considered to be important factors involved in cancer progression. To further understand the correlation between cuproptosis-related genes (CRFGs) LUAD, we explore molecular mechanisms related development disease. We constructed prognostic signature containing 13 CRFGs, which, after grouping...
Fluorescence analysis is an increasingly important contributor to the early diagnosis of kidney diseases. To achieve precise visualization kidneys and related diseases, asymmetric pyrrolopyrrolidone (DPP) dye platform with C-aromatic substituents N-lipophilic/hydrophilic modification was constructed. Based on these, we developed renal-clearable, water-soluble, injury biomarker leucine aminopeptidase (LAP) activated ratiometric fluorescent probe DPP-S-L. In mouse model cisplatin-induced acute...
The selective hydrogenation of carbon-carbon triple bonds to the corresponding double bonds, semi-hydrogenation process, plays a very important role in polymer and fine chemical industry. Various heterogeneous catalysts have been exploited for alkynes alkynols gas liquid phase. Herein, recent progress developing catalysts, from traditional Pd-based monometallic intermetallic compounds single-atom is summarized. activation dihydrogen during full mechanism, along with relevant research...
By optimizing phenyl selenide-based BODIPYs, probe BDP-Se-MOS for detecting Cys was obtained. It could not only discriminate between normal and cancer cells, but also image in tumor-bearing mice as well the fluctuations of DILI model.
The exploitation of stable, high-affinity, and low-cost nanoprobes is essential to develop immunoassays for real-time monitoring foodborne pathogens, so as safeguard human health. possible interaction the Fc fragment antibodies with spA protein on Staphylococcus aureus will result in unexpected interference. To address this consideration, we described herein first time development nanobodies that by definition are devoid fraction. These directed against Cronobacter sakazakii (C. sakazakii)...