A5087247995- Hippo pathway signaling and YAP/TAZ
- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Cell death mechanisms and regulation
- Virus-based gene therapy research
- Immune cells in cancer
- RNA Research and Splicing
Fudan University
2022-2024
Zhongshan Hospital
2022-2024
Shanghai Tenth People's Hospital
2023
Tongji University
2023
Center for Excellence in Molecular Cell Science
2021-2023
University of Chinese Academy of Sciences
2021-2023
Shanghai Institutes for Biological Sciences
2021-2023
Abstract As an important part of tumor microenvironment, neutrophils are poorly understood due to their spatiotemporal heterogeneity in tumorigenesis. Here we defined, at single-cell resolution, CD44 −CXCR2 − as tumor-specific (tsNeus) both mouse and human gastric cancer (GC). We uncovered a Hippo regulon with unique YAP signature genes (e.g., ICAM1, CD14, EGR1) distinct from those identified epithelial and/or cells. Importantly, knockout YAP/TAZ neutrophiles impaired differentiation into...
The striatin-interacting phosphatase and kinase (STRIPAK) complexes integrate extracellular stimuli that result in intracellular activities. Previously, we discovered STRIPAK is a key machinery responsible for loss of the Hippo tumor suppressor signal cancer. Here, identified Hippo-STRIPAK complex as an essential player control DNA double-stranded break (DSB) repair genomic stability. Specifically, found mammalian STE20-like protein kinases 1 2 (MST1/2), independent classical signaling,...
<title>Abstract</title> Therapeutic targeting of tumor-infiltrated regulatory T (TI-Treg) cells is attracting for cancer treatment; yet current ways remain lacking selectivity and efficiency. Due to its crucial role in protein homeostasis cell proliferation, the ATPase p97 complex with cofactors such as Npl4 has been intensively investigated a drug target. However, whether plays immune unclear. Instead directly inhibiting enzymatic activity usual, here we first performed an AlphaScreen using...
Abstract Neutrophils are important for tumor immunosurveillance; yet their roles in tumorigenesis remain debating due to incomplete understanding of heterogeneity and functional plasticity. Here we resolve at single-cell resolution the neutrophils tumor-bearing mice patients with gastric cancer. Our results define CXCR2negCD44neg as a tumor-specific (tsNeu) population activated (CD14high) but atavistic phenotypes (CD53highCD63high). Human mouse tsNeus can be further classified into four...