A5073531276- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Insect and Arachnid Ecology and Behavior
- Advanced Neural Network Applications
- Neurobiology and Insect Physiology Research
- Animal Behavior and Reproduction
- Autonomous Vehicle Technology and Safety
- Cancer Research and Treatments
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Cancer Immunotherapy and Biomarkers
- Polyamine Metabolism and Applications
- Antimicrobial Peptides and Activities
- Immunotherapy and Immune Responses
- Video Surveillance and Tracking Methods
- Risk and Safety Analysis
- Polymer Surface Interaction Studies
- Industrial Vision Systems and Defect Detection
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related Molecular Pathways
- Gene Regulatory Network Analysis
- Phagocytosis and Immune Regulation
- Cancer Cells and Metastasis
- Advanced Nanomaterials in Catalysis
Guang’anmen Hospital
2024-2025
China Academy of Chinese Medical Sciences
2025
Tongji University
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Shanghai Tenth People's Hospital
2019-2023
Institute for Biomedical Engineering
2020
Shanghai East Hospital
2019
Cancer immunotherapy has achieved promising clinical responses in recent years owing to the potential of controlling metastatic disease. However, there is a limited research prove superior therapeutic efficacy on breast cancer compared with melanoma and non-small-cell lung because its expression PD-L1, low infiltration cytotoxic T lymphocytes (CTLs), high level myeloid-derived suppressor cells (MDSCs). Herein, multifunctional nanoplatform (FA-CuS/DTX@PEI-PpIX-CpG nanocomposites, denoted as...
Abstract As an important part of tumor microenvironment, neutrophils are poorly understood due to their spatiotemporal heterogeneity in tumorigenesis. Here we defined, at single-cell resolution, CD44 −CXCR2 − as tumor-specific (tsNeus) both mouse and human gastric cancer (GC). We uncovered a Hippo regulon with unique YAP signature genes (e.g., ICAM1, CD14, EGR1) distinct from those identified epithelial and/or cells. Importantly, knockout YAP/TAZ neutrophiles impaired differentiation into...
Abstract Abnormal inflammatory states in the brain are associated with a variety of diseases. The dynamic changes number and function immune cells cerebrospinal fluid (CSF) advantageous for early prediction diagnosis diseases affecting brain. aggregated factors inflamed CSF may represent candidate targets therapy. physiological barriers brain, such as blood‒brain barrier (BBB), establish stable environment distribution resident cells. However, underlying mechanism by which peripheral migrate...
Abstract The chemical generation of singlet oxygen ( 1 O 2 ) by the MoO 4 2− ‐catalyzed disproportionation hydrogen peroxide (H has been widely applied in numerous catalytic processes; however, such molybdate ions cannot be administered for redox‐based cancer therapeutics. This work reports albumin‐mediated biomimetic synthesis highly active molybdenum sulfide (denoted MoB) nanocatalysts that mediate simultaneous and superoxide anion (O •− from H , which is relatively abundant malignant...
In any gamogenetic species, attraction between individuals of the opposite sex promotes reproductive success that guarantees their thriving. Consequently, mate determination two sexes is effortless for an animal. However, choosing a spouse from numerous attractive partners needs deliberation. Drosophila melanogaster, both younger virgin females and older ones are equally liked options to males; nevertheless, when given options, males prefer ones. Non-volatile cuticular hydrocarbons,...
Background: Acute gastrointestinal syndrome (AGS) is one of the most severe clinical manifestations after exposure to high doses radiation, and life-threatening in radiological emergency scenarios. However, an unmet challenge lacking FDA-approved drug that can ameliorate damage radiation-exposed intestinal tissues accelerate regeneration injured epithelia. In this study, we investigated whether small molecule Me6TREN (Me6) regulate stem cell (ISC) proliferation promote crypt irradiation....
Engineering of cell surfaces holds promise in manipulating cellular activities a physicochemical route as complement to the biological approach. Mediated by Ca2+, quick and convenient yet cytocompatible method is used achieve surface engineering, which polydopamine nanostructures can be situ grown onto dendritic (DC) within 10 min. physical bridge between negative polydopamine, avoids direct chemical polymerization surface, critically important maintain viability. As proof concept potential...
Tumor cells, caged by the protein shell, are mediated to an immunogenic cell death and transformed into a hot vaccine. Such vaccine protects 75% pre-immunized mice against tumor initiation significantly retards established growth.
By incorporating an artificial reactive oxygen species (ROS) generation mechanism, a biotic/abiotic integration is designed to improve the anti-tumor effect of neutrophils by artificially potentiating their ROS effector mechanism in remotely controlled route. Specifically, photosensitizer Ce6 nano-packaged albumin BSA achieve biocompatible and efficient with (NEs). Reinfusion engineered NEs into 4T1 tumor-bearing mice led more accumulation tumors relative nanoformulation. At peak...
Remodeling of cellular surfaces is shown highly effective in the manipulation and control cell behaviors via nonbiological means. By 5-thio-2-nitrobenzoate-mediated, fast, reversible disulfide-thiol exchange, a sequential layer by assembly process was developed to grow albumin protein shells on fixed disulfide-linked network, cytocompatible manner. The artificial shells, accomplished double-assembly process, were sustainable up >1 day, thereafter gradually bioabsorbed with unaffected...
The spindle assembly checkpoint (SAC) is a critical monitoring device in mitosis for the maintenance of genomic stability. Specifically, SAC complex comprises several factors, including Mad1, Mad2, and Bub1. Ataxia-telangiectasia mutated (ATM) kinase, crucial regulator DNA damage response (DDR), also plays role by regulating Mad1 dimerization SAC. Here, we further demonstrated that ATM negatively regulates phosphorylation another component SAC, which involved DDR. Mechanistically, found Mad2...
Lane detection based on the visual sensor is of great significance for environmental perception intelligent vehicle. Current mature lane algorithms are trained and implemented in good conditions. However, low-light environment such as night much more complex, easily causing misdetections even failures, which harmful to downstream tasks behavior decision control ego-vehicle. To tackle this problem, we propose a new algorithm that introduces multi-light information into task. The proposed...