A5111014247- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Bacterial biofilms and quorum sensing
- Pneumocystis jirovecii pneumonia detection and treatment
- Ideological and Political Education
- Peptidase Inhibition and Analysis
- Phytochemical Studies and Bioactivities
- Essential Oils and Antimicrobial Activity
- Carbohydrate Chemistry and Synthesis
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Garlic and Onion Studies
- Bacterial Genetics and Biotechnology
- Immunotherapy and Immune Responses
- Pharmacological Effects of Natural Compounds
- Fungal Plant Pathogen Control
- Chromatography in Natural Products
- Parasitic Diseases Research and Treatment
- Nephrotoxicity and Medicinal Plants
- Heat shock proteins research
- Immunodeficiency and Autoimmune Disorders
- Berberine and alkaloids research
- Bioactive Compounds and Antitumor Agents
- Advanced Drug Delivery Systems
- SARS-CoV-2 and COVID-19 Research
Shanghai Tenth People's Hospital
2015-2023
Tongji University
2013-2023
Chinese People's Liberation Army
2007-2011
Beijing Institute of Technology
2010-2011
People's Liberation Army No. 150 Hospital
2009-2011
Chinese PLA General Hospital
2007-2009
Chinese General Hospital College of Nursing and Liberal Arts
2007
Second Military Medical University
2005-2006
Corona Virus Disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is seriously threatening human health. Following SARS-CoV-2 infection, immune cell infiltration creates an inflammatory and oxidative microenvironment, which can cause pneumonia, syndrome, kidney failure, even death. Clinically, a safe effective treatment strategy remains to be established. Herein, nano-bait for inhibition of infection redirecting viral attack while...
Candida albicans is the most common opportunistic fungal pathogen which can cause life-threatening bloodstream infections known as candidaemia. It very important to discover new drugs and targets for treatment of In this study, we first investigated combination antifungal effects small molecule ENOblock fluconazole (FLC) against FLC-resistant C. albicans. A checkerboard microdilution assay showed that has a significant synergistic effect in with FLC The time-kill curve further confirmed...
Influence of iron-depletion on twitching motility and quorum sensing (QS) system in P. aeruginosa was evaluated. The results demonstrated can retard biofilm formation increase the expression QS-related genes, suggesting a potential interaction between QS formation.
Invasive candidiasis (IC) is one of the leading causes death among immunocompromised patients. Because limited effective therapy treatment options, prevention IC through vaccine an appealing strategy. However, how to induce generation direct candidacidal antibodies in host remains unclear. Gpi7 mutant C. albicans avirulent strain that exposes cell wall β-(1,3)-glucans. Here, we found vaccination with gpi7 could protect mice against invasive caused by and non-albicans Candida spp. The...
Background Candida albicans infections are particularly prevalent in immunocompromised patients. Even with appropriate treatment current antifungal drugs, the mortality rate of invasive candidiasis remains high. Many positive results have been achieved vaccine development. There also issues such as vaccine’s protective effect is not persistent. Considering functionality and cost vaccine, it important to develop safe efficient new vaccines long-term effects. In this paper, an nanovaccine...
We designed and developed a novel DNA topoisomerase I inhibitor MF-6, which was more potent cytotoxin inducer of immunogenic cell death compared with DXd. To utilize MF-6's ability to induce antitumor immunity, human epidermal growth factor receptor 2 (HER2)-targeted antibody–drug conjugate (ADC) trastuzumab-L6 that included cleavable linker MF-6 developed. Different from traditional cytotoxic ADC, the activity assessed by inducing tumor death, activating dendritic cells CD8+ T acquire...
Abstract We have conducted systematic structural modification, deconstruction, and reconstruction of the berberine core with aim lowering its cytotoxicity, investigating pharmacophore, ultimately, seeking novel synergistic agents to restore effectiveness fluconazole against fluconazole‐resistant Candida albicans. A structure–activity relationship study 95 analogues led us identify scaffold N ‐(2‐(benzo[ d ][1,3]dioxol‐5‐yl)ethyl)‐2‐(substituted phenyl)acetamides 7 a – l , which exhibited...
Overexpression of Candida drug resistance 1 (CDR1) gene in albicans (C. albicans), an efflux pump, is one the major mechanisms contributing to resistance. C. for fluconazole protein (Fcr1p) a member family zinc cluster proteins homologous Pdr1p and Pdr3p (pleiotropic protein) mediating azole Saccharomyces cerevisiae (S. cerevisiae) by regulating expression pleiotropic 5 (PDR5) CDR1. A previous study has showed that (FCR1) could also confer S. pdr1 pdr3 mutant PDR5. Therefore, we investigated...
A new compounds neopaleaceolactoside (1), along with nine known phyllocoumarin (2), quercetin (3), quercitrin (4), quercetin-3-methyl ether (5), vincetoxicoside B (6), isoquercitrin (7), kaempferol (8), (-)-epicatechin (9), and chlorogenic acid (10), was isolated from Polygonum paleaceum Wall. Their chemical structures were established based on one-dimensional two-dimensional nuclear magnetic resonance techniques, mass spectrometry by comparison spectroscopic data reported. Some selected...
In the course of optimizing GPI biosynthesis inhibitors, we designed and synthetized a 2-aminonicotinamide derivative named 11g. After evaluating antifungal activity compound 11g in vitro, investigated influences on fungi immunogenicity. addition, also took advantage murine systemic candidiasis model to investigate protective effects vivo. Results show that exhibited potent both vitro Further study shows caused unmasking β-glucan layer, leading stronger immune responses macrophages through...
Candida albicans is a common fungal pathogen in humans that colonizes the skin and mucosal surfaces of majority healthy individuals. How C. disseminates into bloodstream causes life-threatening systemic infections immunocompromised patients remains unclear. Plasminogen system activation can degrade variety structural proteins vivo involved several homeostatic processes. Here, for first time, we characterized could capture "subvert" host plasminogen to invade epithelial cell surface barriers...
Abstract Based on the structures of reported compounds G884 [ N ‐(3‐(pentan‐2‐yloxy)phenyl)nicotinamide], E1210 [3‐(3‐(4‐((pyridin‐2‐yloxy)methyl)benzyl)isoxazol‐5‐yl)pyridin‐2‐amine], and 10 b [2‐amino‐ ‐((5‐(3‐fluorophenoxy)thiophen‐2‐yl)methyl)nicotinamide], which inhibit biosynthesis glycosylphosphatidylinositol (GPI)‐anchored proteins in fungi, a series novel 2‐aminonicotinamide derivatives were designed, synthesized, evaluated for vitro antifungal activity. Most these found to exhibit...
LIGHT is a member of the TNF superfamily, which transiently expressed on surface activated T lymphocytes and immature dendritic cells. Its known receptors are herpesvirus entry mediator (HVEM) prominently in lymphocytes, lymphtoxin β receptor (LTβR) stromal cells or nonlymphoid hematopoietic cells.Previous studies have shown that overexpression could lead to autoimmune reaction including activation, inflammation, tissue destruction. To address role LIGHT/HVEM signaling hepatitis, an...
Candida albicans is a commensal fungus that colonizes most healthy individuals' skin and mucosal surfaces but can also cause life-threatening invasive infections, particularly in immunocompromised patients. Despite antifungal treatment availability, drug resistance increasing, mortality rates remain unacceptably high. Heat shock protein Ssa1, conserved member of the Hsp70 family yeast, novel invasin binds to host cell cadherins, induces endocytosis, enables C. maximal damage cells...
Abstract Objectives Iron plays an important role in the development of Pseudomonas aeruginosa biofilm. Here we evaluated effects iron depletion on antimicrobial activity ceftazidime, tobramycin and ciprofloxacin against planktonic biofilm aeruginosa. Methods We tested sensitivities wild-type PAO1, type-IV pilus mutant PAO-ΔpilHIJK quorum-sensing PAO-JP2 P. cultures biofilms to antibiotics under iron-depleted conditions. Key findings In bacteria, minimum concentration that inhibited visible...