A5101500064- Reproductive System and Pregnancy
- Antifungal resistance and susceptibility
- Industrial Technology and Control Systems
- Immune Cell Function and Interaction
- Power Systems and Renewable Energy
- Phytochemistry and Biological Activities
- Tribology and Lubrication Engineering
- Real-time simulation and control systems
- Preterm Birth and Chorioamnionitis
- Advanced machining processes and optimization
- Aquaculture disease management and microbiota
- Gear and Bearing Dynamics Analysis
- Microbial Natural Products and Biosynthesis
- Pregnancy and preeclampsia studies
- Control Systems in Engineering
- Simulation and Modeling Applications
- IL-33, ST2, and ILC Pathways
- Mechanical Engineering and Vibrations Research
- Power Line Inspection Robots
- Parasitic Diseases Research and Treatment
- Refrigeration and Air Conditioning Technologies
- Shoulder Injury and Treatment
- Chromatography in Natural Products
- Antibiotic Resistance in Bacteria
- Traditional Chinese Medicine Analysis
Guangxi Academy of Fishery Sciences
2025
South China University of Technology
2010-2025
Qingdao Municipal Hospital
2024
Hunan Children's Hospital
2022-2024
Shanghai Tenth People's Hospital
2015-2024
Tongji University
2015-2024
Qingdao University
2024
Ningxia Center for Diseases Prevention and Control
2023
Ningxia Medical University
2023
Shantou University
2003-2022
The syncytialization of cytotrophoblast cells to syncytiotrophoblast is central human placental transport and hormone production. Many techniques for in vitro study this process have been proposed new investigators the field may find literature daunting. Here, we present a straightforward reliable method establish important model using modern but readily available tools reagents.Villous are obtained from term placenta mild enzymatic degradation, Percoll gradient centrifugation, negative...
Abstract Background The understanding of the heterogeneous cellular microenvironment colonic polyps in paediatric patients with solitary juvenile (SJPs), polyposis syndrome (PJS) and Peutz–Jeghers remains limited. Methods We conducted single‐cell RNA sequencing multiplexed immunohistochemistry (mIHC) analyses on both normal tissue different types obtained from patients. Results identified shared disease‐specific cell subsets expression patterns that played important roles shaping unique...
<div class="section abstract"><div class="htmlview paragraph">The electric vehicle thermal management system is a critical sub-systems of vehicles, and has substantial impact on the driving range. The objective this paper to optimize performance heat pump air conditioning system, battery, motor by adopting an integrated design. This approach expected effectively improve COP (Coefficient Performance) cabin heating. An model established using AMEsim. Key parameters, such as...
<div class="section abstract"><div class="htmlview paragraph">With the increasingly prominent environmental problems and energy crisis, wind power, solar power other new has been rapid development, storage technology is of great significance to development energy. Compared with batteries applied in electric vehicles, battery systems gather a larger number scale, usually up megawatts or 100 megawatts. During operation system, lithium-ion continues charge discharge, its internal...
Invariant natural killer T (iNKT) cells are crucial for host defense against a variety of microbial pathogens, but the underlying mechanisms iNKT activation by microbes not fully explained. In this study, we investigated molecular cell in lipopolysaccharide (LPS)-stimulated preterm birth using an adoptive transfer system and diverse neutralizing antibodies (Abs) inhibitors. We found that decidual to LPS-stimulated deficient Jα18−/− mice lack invariant Vα14Jα281T receptor (TCR) expression...
Candida albicans is the most common opportunistic fungal pathogen which can cause life-threatening bloodstream infections known as candidaemia. It very important to discover new drugs and targets for treatment of In this study, we first investigated combination antifungal effects small molecule ENOblock fluconazole (FLC) against FLC-resistant C. albicans. A checkerboard microdilution assay showed that has a significant synergistic effect in with FLC The time-kill curve further confirmed...
Invasive fungal diseases (IFDs) are becoming increasingly acknowledged as a significant concern linked to heightened rates of morbidity and mortality. Regrettably, the available antifungal therapies for managing IFDs constrained. Emerging evidence indicates that enolase holds promise potential target protein combating IFDs; however, there is currently deficiency in medications specifically targeting enolase. This study establishes isobavachalcone (IBC) exhibits noteworthy efficacy both vitro...
A gradual rise in immunocompromised patients over the past years has led to increasing incidence of invasive fungal infections. Development effective fungicides can not only provide new means for clinical treatment, but also reduce occurrence resistance. Here, we identified a antifungal agent, (4-phenyl-1, 3-thiazol-2-yl) hydrazine (numbered as 31C), which showed high-efficiency, broad-spectrum and specific activities. The minimum inhibitory concentration 31C against pathogenic fungi was...
Abstract: Chrysanthemum morifolium extract (CME) has many pharmacological effects, and the effective components of CME are luteolin apigenin which have been reported with cytotoxicity in vitro . The purpose this study was to evaluate safety Sprague–Dawley (S–D) rats. In acute toxicity study, a single oral dose 15 g/kg body weight (bw) administered rats, then rats were observed for 14 d. No treatment‐related death observed, maximal tolerance estimated greater than bw long‐term daily by gavage...
Hormonal contraceptives, particularly depot medroxyprogesterone acetate (DMPA), have been reported to be associated with substantially enhanced HIV acquisition; however, the biological mechanisms of this risk remain poorly understood. We aimed investigate effects different hormonal contraceptives on expression co-receptors, CXCR4 and CCR5, female endocervical peripheral blood T cells. A total 59 HIV-negative women were enrolled, including 15 initiating DMPA, 28 a levonorgestrel-releasing...
Widespread and repeated use of azoles has led to the rapid development drug resistance in Candida albicans. Our previous study found Rta2p, a membrane protein with 7 transmembrane domains, was involved calcineurin-mediated azole sphingoid long-chain base release C. Conserved amino acids domain Rta2p were subjected site-directed mutagenesis. The sensitivity albicans fluconazole vitro examined by minimum inhibitory concentration killing assay, therapeutic efficacy vivo performed systemic mice...
To compare the intraoperative effects of computer navigation-assisted versus simple arthroscopic reconstruction posterior cruciate ligament (PCL) tibial tunnel.
Shikimate pathway plays an essential role in the biosynthesis of aromatic amino acids various plants and bacteria, which consists seven key enzymes they are all attractive targets for antibacterial agent development due to their absence humans. The Staphylococcus aureus dehydroquinate synthase (SaDHQS) is involved second step shikimate pathway, catalyzes NAD + -dependent conversion 3-deoxy-D-arabino-heptulosonate-7-phosphate via multiple steps. enzyme active site can be characterized by two...