A5101566068- Traditional Chinese Medicine Studies
- Traditional Chinese Medicine Analysis
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Ginseng Biological Effects and Applications
- Toxic Organic Pollutants Impact
- Pharmacological Effects of Natural Compounds
- Chronic Lymphocytic Leukemia Research
- Natural product bioactivities and synthesis
- Advanced Biosensing Techniques and Applications
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Medical Research and Treatments
- Plant and animal studies
- Advanced Photocatalysis Techniques
- Analytical Chemistry and Chromatography
- Advanced Chemical Sensor Technologies
- Cancer Treatment and Pharmacology
- Insect and Pesticide Research
- Healthcare and Venom Research
- Medicinal Plant Pharmacodynamics Research
- Lipid metabolism and disorders
- Tryptophan and brain disorders
- Environmental remediation with nanomaterials
- Botulinum Toxin and Related Neurological Disorders
Second Military Medical University
2025
Beihang University
2016-2023
Wuhan Institute of Technology
2022-2023
Tianjin International Joint Academy of Biomedicine
2023
Sun Yat-sen University
2012-2021
Merck & Co., Inc., Rahway, NJ, USA (United States)
2021
Southeast University
2020
State Key Laboratory of Digital Medical Engineering
2020
Peking University
2020
Stanford Blood Center
2018
Diabetes mellitus (DM) is associated with mitochondrial oxidative stress. We have shown that myocardial stress leads to diastolic dysfunction in a hypertensive mouse model. Therefore, we hypothesized diabetes could cause through and mitochondria-targeted antioxidant (MitoTEMPO) prevent diabetic C57BL/6J mice were fed either 60 kcal % fat diet (high-fat [HFD]) or normal chow (control) for 8 weeks without concurrent MitoTEMPO administration, followed by vivo assessment of function ex studies....
Exocarpium Citri grandis (ECG) is an important Traditional Chinese Medicine (TCM) for the treatment of cough and phlegm, flavonoids contained were considered main effective components. To date, systematic chemical profiling these derived in vivo metabolites human have not been well investigated. ECG was extracted using boiling water then provided to volunteers oral administration. Following ingestion, urine samples collected from over 48 h. The extract analyzed ultra-fast liquid...
A two-dimensional resolution system of channels and substrate zones was proposed for multiplex immunoassay performed with a designed multichannel chemiluminescent (CL) detection device coupled single photomultiplier. Using carcinoma antigen 125 (CA 125), 153 153), 199 199), carcinoembryonic (CEA) as two couples model analytes, capture antibodies were immobilized in channels, respectively. With sandwich format, the CL substrates alkaline phosphatase horseradish peroxidase delivered into...
An automated support-resolution strategy was designed to couple with a flow-through immunosensing system for performing one-way chemiluminescent (CL) multiplex immunoassay. Different from multilabel and multichannel-based detection techniques, this immunoassay method employed single horseradish peroxidase (HRP) label in one way. With the use of carcinoembryonic antigen (CEA) alpha-fetoprotein (AFP) as model analytes, capture antibodies CEA AFP were immobilized on inner wall glass tube...
Food allergy is a growing health concern, which currently affects approximately 4% of adults and 8% infants. For consumer protection purposes, food producers are required by law to disclose on the product label whether major allergen used during production process. The commonly employed monitoring methods highly laborious, time-consuming, often expensive when screening for multiple allergens. Here, we utilize imaging surface plasmon resonance (iSPR) in combination with antibody array rapid,...
Bioconcentration factors (BCFs) measured in the laboratory are important for characterizing bioaccumulative properties of chemicals entering environment, especially potential persistent organic pollutants (POPs), which can pose serious adverse effects on ecosystem and human health. Traditional lethal analysis methods time-consuming sacrifice too many experimental animals. In present study, vivo solid-phase microextraction (SPME) was introduced to trace uptake elimination processes pesticides...
The local treatment of inflammatory bowel disease (IBD) by enzyme therapeutics is challenging owing to hostile environments in the gastrointestinal tract, leading hydrolysis and enzymatic degradation labile proteins. In this study, safe efficient drug delivery systems were developed antioxidant superoxide dismutase (SOD) sequestered within lipid-polymer hybrid nanoparticles through sequential self-assembly processes. Interestingly, we found that SOD exhibited long-term stability comparable...
Background: Previous studies have shown that WZC can increase tacrolimus blood concentration when co-administered. However, limited knowledge exists regarding the pharmacokinetics of both and bioactive lignans in administered simultaneously renal transplantation patients. Aims: This study aimed to investigate multiple Wuzhi capsule (WZC) co-administered with 5 components recipients. Objective: The objective this was develop a method for simultaneous quantification using liquid-liquid...
Obesity is characterized by expansion of adipose tissue, which results from an increase in adipocyte number (adipogenesis) and size (lipogenesis). A reversal these processes has been suggested to be a potential antiobetic therapy. Rutaecarpine (Rut) its novel analogues (R17 R18) were identified exert potent effect reducing lipid accumulation during differentiation 3T3-L1 adipocytes with little cytotoxicity. All three compounds reduced dose-dependent manner, while R17 R18 exhibited much more...
Kouyanqing Granule (KYQG) is a traditional Chinese herbal formula composed of Flos lonicerae (FL), Radix scrophulariae (RS), ophiopogonis (RO), asparagi (RA), and et rhizoma glycyrrhizae (RG). In contrast with the typical method separating then biologicalily testing components individually, this study was designed to establish an approach in order define core bioactive ingredients anti-inflammatory effects KYQG based on relevance analysis between chemical characters biological effects....
Background and purpose Promoting energy metabolism is known to provide therapeutic effects for obesity associated metabolic disorders. The present study evaluated the of newly identified bouchardatine (Bou) on obesity‐associated disorders molecular mechanisms these effects. Experimental approach mode action Bou its lipid was first examined in 3T3‐L1 adipocytes HepG2 cells. This followed by an evaluation mice fed a high‐fat diet 16 weeks with being administered last 5 weeks. Further...
Naoxintong capsule (NXT), a Chinese medicine, has performed excellent effects on the prevention and treatment against cardiovascular diseases. NXT is fine powder mixture without any herb extraction, there must be lots of ingredients hard to absorbed. However, little known about correlation between NXT's cardioprotective gut microbiota. Herein, we report effect development diseases clarify In current study, minipigs were selected fed with high-fat diet daily for successive 8 months. During...
The regioselectivity for progesterone hydroxylation by cytochrome P450 2B1 was re-engineered based on the x-ray crystal structure of 2C5. is a highKm 16α-hydroxylase, whereas 2C5 low Km 21-hydroxylase. Initially, nine individual active-site residues were changed to corresponding residues, and mutants purified from an Escherichia coli expression system assayed hydroxylation. At 150 ॖm progesterone, I114A, F297G, V363L showed 5–157 21-hydroxylase activity 2C5, F206V high unknown product...