A5027873831- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Drug Transport and Resistance Mechanisms
- Liver Disease Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Hair Growth and Disorders
- Pharmacogenetics and Drug Metabolism
- Phytochemicals and Antioxidant Activities
- Alcohol Consumption and Health Effects
- Neurological Disease Mechanisms and Treatments
- Cholesterol and Lipid Metabolism
- Berberine and alkaloids research
- Phytochemical Studies and Bioactivities
- Flavonoids in Medical Research
- Fermentation and Sensory Analysis
- Eicosanoids and Hypertension Pharmacology
- Chromatography in Natural Products
- Inflammatory mediators and NSAID effects
- Chronic Kidney Disease and Diabetes
- Pharmacological Effects and Toxicity Studies
- Peroxisome Proliferator-Activated Receptors
- Tea Polyphenols and Effects
- Phytochemistry and biological activity of medicinal plants
Southern Medical University
2016-2025
Beijing University of Chinese Medicine
2022-2024
Risun (China)
2024
Beijing Institute of Technology
2024
TCM-Intigrated Cancer Center of Southern Medical University
2021-2024
Anhui Medical University
2022-2023
Affiliated Hospital of Hangzhou Normal University
2022
Sun Yat-sen University
2012-2014
Hedyotis diffusa is a folk herb that used for treating inflammation-related diseases in Asia. Previous studies have found iridoids H. play an important role its anti-inflammatory activity. This study aimed to investigate the effect and potential mechanism of five (asperuloside (ASP), asperulosidic acid (ASPA), desacetyl (DAA), scandoside methyl ester (SME), E-6-O-p-coumaroyl (CSME)) are presented using lipopolysaccharide (LPS)-induced RAW 264.7 cells. ASP ASPA significantly decreased...
As one of the leading cases acute liver failure triggered by excessive Acetaminophen (APAP), breakdown antioxidant system, inflammatory response, and inescapable apoptosis following overaccumulation reactive oxygen species (ROS) play crucial roles in mechanisms APAP-induced injury (AILI). Therefore, cutting off ROS overproduction at source is considered promising. Here, manganese Prussian blue nanozymes (MPBZs) with superior enzyme-like activity are prepared as an effective strategy for...
Radix Astragali (RA) is one of the commonly-used traditional Chinese medicines (TCMs) with an immunomodulatory effect confirmed in clinic. In order to better understand material basis for therapeutic effects, this study was investigate absorbed components and their pharmacokinetic profile after oral administration RA on cyclophosphamide-induced immunosuppression Balb/c mice. As a result, 51 compounds extract 31 prototype nine metabolites were detected mice plasma by ultra-fast liquid...
The iridoids of
Paeonia suffruticosa is an ornamental, edible, and medicinal plant. The ethanolic extracts of P. bud flower were examined for their antioxidant, anti-photoaging, phytochemical properties prior to chemometric analysis. results showed that the extract (BEE) (the early flowering stage) (FEE) had better antioxidant activities, significantly increased activities superoxide dismutase (SOD) glutathione peroxidase (GSH-Px) reduced levels tumor necrosis factor-α (TNF-α) interleukin-6 (IL-6) in skin...
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic worldwide. Fat accumulation "sensitizes" to insult and leads nonalcoholic steatohepatitis (NASH). G protein-coupled receptor 35 (GPR35) involved in metabolic stresses, but its role NAFLD unknown. We report that hepatocyte GPR35 mitigates NASH by regulating hepatic cholesterol homeostasis. Specifically, we found overexpression hepatocytes protected against high-fat/cholesterol/fructose (HFCF) diet-induced steatohepatitis,...
Alcohol-associated liver disease (ALD) encompasses a wide range of pathologies from simple steatosis to cirrhosis and hepatocellular carcinoma is global health problem.Currently, there are no effective pharmacological treatments for ALD.We have previously demonstrated that aging exacerbates the pathogenesis ALD, but underlying mechanisms still poorly understood.Cellular repressor E1A-stimulated genes 1 protein (CREG1) recently identified small glycoprotein has been implicated in process by...
Background: Long-term intake of a high-fat diet is crucial factor contributing to obesity, which has become global public health problem. Progressive obesity subsequently leads hepatic injury, renal damage and intestinal atrophy. Transporters expressed in the liver, kidney intestine play important roles deposition nutrients drugs, but researchers have not clearly determined whether/how expression transporters changes after long-term administration High-Fat Diet (HFD). This study aims explore...
Microfluidic chips offer high customizability and excellent biocompatibility, holding important promise for the precise control of biological growth at microscale. However, microfluidic employed in studies regulating cell are typically fabricated through 2D photolithography. This approach partially restricts diversity platform designs manufacturing efficiency. paper presents a method designing neural culture (NCMC) using two-photon polymerization (TPP), where discrete directional is...
Androgenetic alopecia (AGA) is a prevalent disease in worldwide, local application or oral are often used to treat AGA, however, effective treatments for AGA currently limited. In this work, we observed the promoting initial anagen phase effect of pilose antler extract (PAE) on hair regeneration mice. We found that PAE accelerated growth and increased degree skin blackness by non-invasive vivo methods including camera, optical coherence tomography dermoscopy. Meanwhile, HE staining sagittal...
Abstract Humantenmine (HMT), the most toxic compound isolated from Gelsemium elegans Benth , is a well‐known active herbal compound. A rapid and sensitive ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method was developed validated to estimate absolute oral bioavailability of HMT in rats. Quantification performed by multiple reaction monitoring using electrospray ionization operated positive ion mode with transitions m/z 327.14 → 296.19 for 323.20 236.23...