A5089633659- Gut microbiota and health
- Immune Cell Function and Interaction
- Alcohol Consumption and Health Effects
- Escherichia coli research studies
- Bacterial Genetics and Biotechnology
- Antimicrobial Peptides and Activities
- Mycotoxins in Agriculture and Food
- CAR-T cell therapy research
- Inflammatory Bowel Disease
- Aquaculture disease management and microbiota
- Animal Nutrition and Physiology
- Viral gastroenteritis research and epidemiology
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Bioactive natural compounds
- Eicosanoids and Hypertension Pharmacology
- T-cell and B-cell Immunology
- Animal Ecology and Behavior Studies
- RNA and protein synthesis mechanisms
- Peptidase Inhibition and Analysis
- Heavy Metals in Plants
- Protein Hydrolysis and Bioactive Peptides
- Salmonella and Campylobacter epidemiology
- Clinical Nutrition and Gastroenterology
- Veterinary Pharmacology and Anesthesia
University of Science and Technology of China
2023-2025
Anhui Medical University
2020-2025
First Affiliated Hospital of Anhui Medical University
2022-2025
Hunan Agricultural University
2020-2024
Huazhong Agricultural University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Wuhan Union Hospital
2024
Anyang Hospital of Traditional Chinese Medicine
2024
Baoding People's Hospital
2023
West China Medical Center of Sichuan University
2022
This study was conducted to investigate serum amino acids profile in dextran sulfate sodium (DSS)-induced colitis, and impacts of graded dose arginine or glutamine supplementation on the colitis. Using DSS-induced colitis model, which is similar human ulcerative we determined at day 3, 7, 10 12 (5 days post DSS treatment). Meanwhile, effects (0.4%, 0.8%, 1.5%) (0.5%, 1.0% 2.0%) clinical parameters, acids, colonic tight junction proteins, anti-oxidative indicators [catalase, total superoxide...
With the widespread ban on use of antibiotics in swine feed, alternative measures need to be sought maintain health and performance. Antimicrobial peptides (AMPs) are part nonspecific defense system natural produced by plants, insects, mammalians, micro-organisms as well chemical synthesis. Due their broad microbicidal activity against various fungi, bacteria enveloped viruses, AMPs a potential conventional for production. This review focuses structure mechanism action AMPs, effects...
Deoxynivalenol (DON) affects animal and human health targets the gastrointestinal tract. The objective of this study was to evaluate ability composite antimicrobial peptides (CAP) repair intestinal injury in piglets challenged with DON. A total 28 (Duroc × Landrace Large Yorkshire) weaned at d age were randomly assigned receive 1 4 treatments (7 pigs/treatment): negative control, basal diet (NC), + 0.4% peptide (CAP), mg/kg DON (DON), CAP (DON CAP). After an adaptation period 7 d, blood...
Scope Glutamine supplementation enhances secretory IgA (SIgA) production in the intestine, but mechanism is largely unknown. We examined this issue using a mouse model. Methods and Results In model, glutamine increased both SIgA abundance intestinal luminal contents + plasma cell numbers ileum, decreased bacterial loads mesenteric lymph nodes. ileal expression of cytokines associated with T cell‐dependent cell‐independent pathways induction, including IL‐5, IL‐6, IL‐13, transforming growth...
The mycotoxin deoxynivalenol (DON) is a food contaminant that leads to reduced feed intake and BW gain, as well organ impairment. On the other hand, antimicrobial peptides have been shown positive effects on growth performance, nutrient digestibility, immune function. purpose of this study was investigate protective composite (CAP) piglets challenged with DON. After 7-d adaptation period, 28 individually housed (Duroc × Landrace Large Yorkshire) weaned at d age were randomly assigned receive...
The mycotoxin deoxynivalenol (DON), one of the most common food contaminants, primarily targets gastrointestinal tract to affect animal and human health. This study was conducted examine protective function glutamic acid on intestinal injury oxidative stress caused by DON in piglets. Twenty-eight piglets were assigned randomly into 4 dietary treatments (7 pigs/treatment): 1) uncontaminated control diet (NC), 2) NC+DON at mg/kg 3) NC+2% (GLU), 4) + (DG). At day 15, 30 37, blood samples...
Polyamines are necessary for normal integrity and the restitution after injury of gastrointestinal epithelium. The objective this study was to investigate effects oral administration putrescine proline during suckling period on epithelial early weaning in piglets. Eighteen neonatal piglets (Duroc × Landrace Large Yorkshire) from 3 litters (6 per litter) were assigned groups, representing with an equal volume saline (control), (5 mg/kg BW), (25 BW) twice daily d 1 at 14 age. Plasma intestinal...
The bacterial effector proteins SseK and NleB glycosylate host on arginine residues, leading to reduced NF-κB-dependent responses infection. Salmonella SseK1 SseK2 are E. coli NleB1 orthologs that behave as NleB1-like GTs, although they differ in protein substrate specificity. Here we report these enzymes retaining glycosyltransferases composed of a helix-loop-helix (HLH) domain, lid catalytic domain. A conserved HEN motif (His-Glu-Asn) the active site is important for enzyme catalysis...
The purpose of this study was to investigate the hypothesis that dietary supplementation with glutamic acid has beneficial effects on growth performance, antioxidant system, intestinal morphology, serum amino profile and gene expression transporters in growing swine fed mold-contaminated feed. Fifteen pigs (Landrace×Large White) a mean body weight (BW) 55 kg were randomly divided into control group (basal feed), mycotoxin (contaminated feed) glutamate (2% glutamate+contaminated feed)....
Pasteurella multocida causes a variety of infectious diseases in various species mammals and birds, resulting enormous economic loss to the modern livestock poultry industry. However, mechanism host-pathogen interaction is unclear. Here, we found that l -serine levels were significantly decreased murine lungs infected with P. .
Abstract Aging disrupts the maintenance of liver homeostasis, which impairs hepatocyte regeneration and aggravates acute injury (ALI), ultimately leading to development failure (ALF), a systemic inflammatory response, even death. Macrophages influence progression outcome ALI through innate immune system. However, it is still unclear how macrophages regulate during aging. The variation in macrophage autophagy with aging on polarization cytokine release were assessed BMDMs vitro. Then, after...
ABSTRACT Toll‐like receptors (TLRs) play a crucial role in the immune response to pathogen invasion. The TLR patterns teleost are significantly different from those mammals. In this study, we systematically identified and characterized family of crucian carp ( Carassius auratus) . Phylogenetic analysis revealed that Ca consists 25 members, divided into six subfamilies, highlighted their homologous relationships with other species. mRNA expression TLRs demonstrated most members exhibited...
Self-amplifying RNA (saRNA), derived from alphaviruses, encodes nonstructural proteins (NSP1-4) that form a replicase complex, enabling prolonged and amplified protein expression at lower doses than conventional mRNA. However, its high immunogenicity limited replication efficiency require optimization for improved expression. Here, we systematically optimized widely used Venezuelan Equine Encephalitis Virus (VEEV)-based saRNA by refining capping structure, nucleotide modifications, polyA...
The neonatal small intestine is susceptible to damage caused by oxidative stress. This study aimed evaluate the protective role of antioxidant N-acetylcysteine (NAC) in intestinal epithelial cells against induced H2O2. IPEC-J2 were cultured DMEM-H with NAC and After 2-day incubation, collected for analysis DNA synthesis, antioxidation capacity, mitochondrial respiration, cell apoptosis. results showed that H2O2 significantly decreased (P < 0.05) proliferation rate, capacity increased...