A5015868817- Gut microbiota and health
- Animal Nutrition and Physiology
- Antifungal resistance and susceptibility
- Immune Cell Function and Interaction
- Clinical Nutrition and Gastroenterology
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Mycotoxins in Agriculture and Food
- Immune cells in cancer
- Probiotics and Fermented Foods
- Meat and Animal Product Quality
- Neonatal Respiratory Health Research
- Adipose Tissue and Metabolism
- Escherichia coli research studies
- Amino Acid Enzymes and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Inflammatory Bowel Disease
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- Clostridium difficile and Clostridium perfringens research
- Tryptophan and brain disorders
- Autophagy in Disease and Therapy
- NF-κB Signaling Pathways
First Affiliated Hospital of Guangzhou Medical University
2022-2025
State Key Laboratory of Respiratory Disease
2022-2025
Guangzhou Medical University
2022-2025
Tongji University
2018-2024
Shanghai Tenth People's Hospital
2020-2024
Capital Medical University
2023
Hunan Agricultural University
2022
Education Department of Hunan Province
2022
Institute of Subtropical Agriculture
2013-2021
Shanghai Pulmonary Hospital
2019
The objective of this experiment was to investigate oxidative injury and the development an antioxidant system after early weaning in piglets. A total 40 piglets (Landrace× Large White, weaned at 14 d birth) were randomly slaughtered 0 (w0d), 1 (w1d), 3 (w3d), 5 (w5d), or 7 (w7d; n = 8) weaning. Concentrations malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), protein carbonyl activities superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase measured plasma. Gene...
Birth oxidative stress is an response to a sudden transition process from maternal mediated respiration in uterus autonomous pulmonary outside the uterus. Meanwhile, has been demonstrated be associated with various pathologies recorded newborns. So, this research aimed study and development of antioxidant system newborn piglets. The measured variables include plasma lipid, protein DNA oxidant injury, activities enzymes jejunal ileal gene expressions at 1, 7, 14, 21 days after birth. nuclear...
This study aimed to investigate the protective effects of dietary glutamate and aspartate supplementations on diquat-induced oxidative stress in piglets. Diquat injection significantly reduced growth performance, including body weight, average daily weight gain, feed intake (P<0.05). Meanwhile, diquat administration induced evidenced by decreased serum nitric oxide (NO) elevated malondialdeyhde (MDA) concentration Furthermore, disrupted intestinal absorption system threonine, serine, glycine...
This study was conducted to investigate serum amino acids profile in dextran sulfate sodium (DSS)-induced colitis, and impacts of graded dose arginine or glutamine supplementation on the colitis. Using DSS-induced colitis model, which is similar human ulcerative we determined at day 3, 7, 10 12 (5 days post DSS treatment). Meanwhile, effects (0.4%, 0.8%, 1.5%) (0.5%, 1.0% 2.0%) clinical parameters, acids, colonic tight junction proteins, anti-oxidative indicators [catalase, total superoxide...
H<sub>2</sub>O<sub>2</sub> induces autophagy and activates NF-κB Nrf2/Keap1 signals in a piglet model.
Chitosan oligosaccharide (COS) is a degradation product of chitosan with antioxidative, anti-inflammatory, and antibacterial effects. This study was conducted to investigate the effects dietary COS on intestinal inflammatory response calcium-sensing receptor (CaSR) nuclear transcription factor kappa B (NF-κB) signaling pathways that may be involved using lipopolysaccharide (LPS)-challenged piglet model. A total 40 weaned piglets were used in 2 × factorial design; main factors treatment...
Fusarium infection with concurrent production of deoxynivalenol (DON) causes an increasing safety concern feed worldwide. This study was conducted to determine the effects varying levels DON in diets on growth performance, serum biochemical profile, jejunal morphology, and differential expression nutrients transporter genes growing pigs.A total twenty-four 60-day-old healthy pigs (initial body weight = 16.3 ± 1.5 kg SE) were individually housed randomly assigned receive one four containing...
Abstract Gut microbiota is an intricate microbial community containing bacteria, fungi, viruses, archaea, and protozoa, each of them contributes to diverse aspects host health. Nevertheless, the influence interaction among gut on health remains uncovered. Here, we showed that between intestinal fungi bacteria shaped lung inflammation during infection. Specifically, antifungal drug‐induced dysbiosis mycobiota enhanced Dysbiosis led Escherichia coli ( E. ) overgrowth translocation infection,...
The purpose of this study was to investigate the hypothesis that dietary supplementation with glutamic acid has beneficial effects on growth performance, antioxidant system, intestinal morphology, serum amino profile and gene expression transporters in growing swine fed mold-contaminated feed. Fifteen pigs (Landrace×Large White) a mean body weight (BW) 55 kg were randomly divided into control group (basal feed), mycotoxin (contaminated feed) glutamate (2% glutamate+contaminated feed)....
This study was conducted to determine the positive effects of dietary supplementation with L-arginine (Arg) on piglets fed a deoxynivalenol (DON)-contaminated diet. A total eighteen, 28-day-old healthy weanling pigs were randomly assigned into one three groups: uncontaminated basal diet (control group), 6 mg/kg DON-contaminated (DON group) and DON + 1% ARG group). After 21 days Arg supplementation, in groups challenged by feeding for seven days. The results showed that resulted damage...
The incidence of Aspergillus fumigatus infection and the rate resistance to antifungal drugs have sharply increased in recent years. LL37 has been reported as a host defense peptide with broad-spectrum antibacterial activities. However, role during A. remains unclear. Here, we examined interaction between found that synthetic could directly bind surface fumigatus, disrupting integrity cell wall vitro. inhibited mycelial growth concentration-dependent manner, rather than fungicidal effect...
c-Cbl suppresses RelB activation to facilitate protective benefits of commensal fungi and maintain intestinal homeostasis.
Deoxynivalenol (DON) has various toxicological effects in humans and pigs that result from the ingestion of contaminated cereal products. This study was conducted to investigate protective dietary supplementation with glutamic acid on piglets challenged DON. A total 20 weaned at 28 d age were randomly assigned receive 1 4 treatments (5 piglets/treatment): 1) basal diet, negative control (NC); 2) diet +4 mg/kg DON (DON); 3) +2% (g/g) (GLU); 4) (DG). 7-d adaptation period followed by 30 days...
The γ-amino butyric acid (GABA)ergic system shapes the activation and function of immune cells. present study was conducted to explore regulation GABA transporter (GAT)-2 on differentiation Th17 Here we found that cells show higher abundance GAT-2, have distinct cellular metabolic signatures, such as shunt pathway, compared naïve T GAT-2 deficiency had little effect signature in cells, but impaired uptake pathway cell development peripheral homeostasis; however, its promoted vitro....
Abstract Enterotoxigenic Escherichia coli (ETEC) is a common cause of diarrhea in humans and livestock. In this study, isobaric tags for relative absolute quantitation (iTRAQ) combined with multidimensional liquid chromatography (LC) MS analysis was used screening the differentially expressed proteins piglet jejunum after ETEC infection. Totally 1,897 were identified quantitative information jejunum. We 92 ETEC-induced diarrhea, which 30 up regulated 62 down regulated. Most involved...
Abstract Epithelial cells play a crucial role in asthma, contributing to chronic inflammation and airway hyperresponsiveness. m6A modification, which involves key proteins such as the demethylase fat mass obesity‐associated protein (FTO), is regulation of various diseases, including asthma. However, FTO epithelial development asthma remains unclear. In this study, we investigated activity using small‐molecule inhibitor FB23 allergic vivo vitro. We examined FTO‐regulated transcriptome‐wide...