A5100336966- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Pesticide Residue Analysis and Safety
- Food Allergy and Anaphylaxis Research
- Analytical Methods in Pharmaceuticals
- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Respiratory and Cough-Related Research
- Analytical Chemistry and Chromatography
- Pharmacological Effects and Assays
- Plant-based Medicinal Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Antibiotics Pharmacokinetics and Efficacy
- Immune Response and Inflammation
- interferon and immune responses
- Natural product bioactivities and synthesis
- Contact Dermatitis and Allergies
- Pesticide and Herbicide Environmental Studies
- IL-33, ST2, and ILC Pathways
- Insect and Pesticide Research
- Eosinophilic Esophagitis
- Gut microbiota and health
- Entomological Studies and Ecology
First Affiliated Hospital of Guangzhou Medical University
2015-2025
Guangzhou Medical University
2015-2025
State Key Laboratory of Respiratory Disease
2014-2024
Lanzhou University
2024
Institute of Pomology
2016-2023
Chinese Academy of Agricultural Sciences
2009-2023
People's Hospital of Yangzhong
2021
National Clinical Research
2021
Kaifeng City Children's Hospital
2020
Citrus Research Institute
2019
A sequenced house dust mite (HDM) genome would advance our understanding of HDM allergens, a common cause human allergies.We sought to produce an annotated Dermatophagoides farinae draft and develop combined genomic-transcriptomic-proteomic approach for elucidation allergens.A D transcriptome were assembled with high-throughput sequencing, accommodating microbiome sequences. The allergen gene structures validated by means Sanger sequencing. mite's composition was determined, the predominant...
To the Editor, Allergen sensitization occurs in most patients with asthma. Our previous article had demonstrated that house dust mite remained important allergen Chinese individuals asthma.1 A raised serum IgE against Aspergillus antigens usually occurred bronchial asthma, especially a value ≥1000 IU/mL was recommended as total (tIgE) cut-off to diagnose Allergic bronchopulmonary aspergillosis (ABPA).2 Therefore, we aim describe prevalence of common allergens among asthmatic tIgE >1000...
Chronic obstructive pulmonary disease (COPD) is a severely disabling chronic lung characterized by persistent airway inflammation, which leads to limited expiratory airflow that deteriorates over time. Isorhamnetin (Iso) one of the most important active components in fruit Hippophae rhamnoides L. and leaves Ginkgo biloba L, widely used many studies because its anti-inflammatory effects. Here, we investigated pharmacological action Iso CS-induced inflammation dissected anti-inflammation...
Rural environments and microbiota are linked to a reduction in the prevalence of allergies. However, mechanism underlying reduced allergies modulated by rural residency is unclear. Here, we assessed gut bacterial composition metagenomics urban children EuroPrevall-INCO cohort. Airborne dusts, including mattress henhouse were profiled for fungal amplicon sequencing. Mice repeatedly exposed intranasal dust extracts evaluated their effects on ovalbumin (OVA)-induced allergic airway...
The association between sensitizations and severity of allergic diseases is controversial.
<b><i>Background:</i></b> Few studies have directly compared the immunologic responses to specific subcutaneous immunotherapy (SCIT) and sublingual (SLIT). <b><i>Objective:</i></b> We aimed compare clinical efficacy immunological between SLIT SCIT in allergic rhinitis (AR) sensitized house dust mites. <b><i>Methods:</i></b> Sixty-seven patients (age 5–55 years) with moderate-severe <i>Dermatophagoides...
Little is known about the changes in allergen sensitization China secondary to environmental variations over past decade. We aimed at investigating among asthma and/or rhinitis patients between 2008 and 2018.This study analyzed cross-sectional data from national surveys conducted 2018. After finishing questionnaire, participants underwent serum specific IgE measurements. A total of 2322 2798 were enrolled 2018, respectively. The significance differences rates four regions assessed....
This study was designed to elucidate the pharmacokinetics, absorption, tissue distribution and plasma protein binding properties of tanshinone IIA, a highly lipophilic compound isolated from Salvia miltiorrhiza. Tanshinone IIA using previously well developed LC-MS/MS method. Its pharmacokinetic characteristics, absolute bioavailability, were determined. The membrane permeability evaluated Caco-2 cells in monolayer. profile after single intravenous dosing exhibited triexponential pattern...
Abstract Calcium-activated potassium ion channel-3.1 (KCa3.1) plays a pivotal role in the potassium-calcium exchange involved atopy. This study aimed to explore impact of lentiviral-mediated shRNA silencing KCa3.1 on allergic response murine rhinitis (AR) model. The BALB/c mice were divided into four groups: untreated AR group, negative control lentiviral KCa3.1-shRNA treated group and normal group. Concentrations ovalbumin (OVA)-specific IgE, histamine leukotrienes C4 (LTC4) serum IL-4,...
Quinones represent a very important class of compounds found in nature and for the chemically synthesized drugs. The present study was designed to elucidate intestinal first pass metabolic pathways vivo vitro, tanshinone IIA (TS), derivative phenanthrene-quinone isolated from Salvia miltiorrhiza. Five metabolites, proposed be TS catechol glucuronides (two position isomers), dehydrotanshinone its two glucuronides, were identified rat homogenates after oral administration TS. metabolism...
Background: Specific IgG4 induced by allergen-specific immunotherapy (SIT) is an immunological marker related to the appearance of clinical tolerance. But specific levels in different age, gender and allergic disease populations have not been fully investigated. Methods: This study involved 226 children 109 adults with rhinitis and/or asthma receiving a 156-week course Dermatophagoides pteronyssinus (Der p) subcutaneous SIT. Symptom medication scores, forced expiratory volume after 1 s...
Whether allergen immunotherapy (AIT) could reduce allergy effector cell activation is unclear. We aimed to evaluate the basophil response during Dermatophagoides pteronyssinus (Der p) subcutaneous (SCIT) and its relationship specific IgG4 (sIgG4) in allergic rhinitis and/or asthma patients. The study included a total of 55 subjects, which 35 cases received Der p SCIT 20 controls regular medications. Symptom medication scores (SMS), sIgG4 levels, IgE (sIgE) allergen-induced test (BAT) whole...
Abstract Epithelial cells play a crucial role in asthma, contributing to chronic inflammation and airway hyperresponsiveness. m6A modification, which involves key proteins such as the demethylase fat mass obesity‐associated protein (FTO), is regulation of various diseases, including asthma. However, FTO epithelial development asthma remains unclear. In this study, we investigated activity using small‐molecule inhibitor FB23 allergic vivo vitro. We examined FTO‐regulated transcriptome‐wide...
ABSTRACT A rapid, highly sensitive and selective method was developed for the determination of cyantraniliprole its major metabolite J9Z38 in cucumber, tomato soil by ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS). Target compounds were extracted with acetonitrile an aliquot cleaned primary secondary amine. Two pairs precursor product ion transitions measured evaluated. Average recoveries at three levels (10, 50 100 µg/kg) ranged from 74.7 to 96.2% intra‐day...