A5011605775- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Pediatric health and respiratory diseases
- Receptor Mechanisms and Signaling
- Dermatology and Skin Diseases
- Cytokine Signaling Pathways and Interactions
- Respiratory and Cough-Related Research
- Protein Structure and Dynamics
- Computational Drug Discovery Methods
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- RNA Interference and Gene Delivery
- Protein Kinase Regulation and GTPase Signaling
- Traditional Chinese Medicine Analysis
- Congenital heart defects research
- Enzyme Catalysis and Immobilization
- Lipid Membrane Structure and Behavior
- Blood Coagulation and Thrombosis Mechanisms
- Mass Spectrometry Techniques and Applications
- Effects and risks of endocrine disrupting chemicals
- DNA and Nucleic Acid Chemistry
- Acute Lymphoblastic Leukemia research
- Cardiovascular Issues in Pregnancy
- melanin and skin pigmentation
- Childhood Cancer Survivors' Quality of Life
Nanjing Agricultural University
2021-2024
Shanghai Jiao Tong University
2024
First Hospital of Lanzhou University
2023
Lanzhou University
2023
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2014-2022
Wenzhou Medical University
2006-2022
Central South University of Forestry and Technology
2022
Central South University
2022
Tianjin University of Traditional Chinese Medicine
2019-2020
Nanchang University
2017-2018
Journal Article Identification of a patient with Bernard-Soulier syndrome and deletion in the DiGeorge/Velo-cardio-facial chromosomal region 22q11.2 Get access Marcia L. Budarf, Budarf * 1Divisions Human Genetics Molecular Biology34th Street Civic Center Boulevard, Philadelphia, PA 19104, USA2Departments PediatricsPhiladelphia, PA, USA *To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Barbara A. Konkle, Konkle 3The...
Little is known about the changes in allergen sensitization China secondary to environmental variations over past decade. We aimed at investigating among asthma and/or rhinitis patients between 2008 and 2018.This study analyzed cross-sectional data from national surveys conducted 2018. After finishing questionnaire, participants underwent serum specific IgE measurements. A total of 2322 2798 were enrolled 2018, respectively. The significance differences rates four regions assessed....
Parathyroid hormone (PTH) type 1 receptor (PTH1R), as a typical class B1 G protein-coupled (GPCR), is responsible for regulating bone turnover and maintaining calcium homeostasis, its dysregulation has been implicated in the development of several diseases. The extracellular domain (ECD) PTH1R crucial recognition binding ligands, may exhibit an autoinhibited state with closure ECD absence ligands. However, correlation between conformations activation remains unclear. Thus, this study...
<b><i>Background:</i></b> To date, no predictive methods for the clinical response to allergy immunotherapy (AIT) are available. We sought evaluate pretreatment parameters used in diagnosing allergic asthma and/or rhinitis including allergen skin-prick test responses, serum specific and total IgE (sIgE tIgE) levels blood eosinophil counts, identify whether these can be predict effectiveness children treated with immunotherapy....
The lethal mutation C423D in Fusarium graminearum myosin I (FgMyoI) occurs close to the binding pocket of allosteric inhibitor phenamacril and causes severe inhibition on mycelial growth F. strain PH-1. Here, based extensive Gaussian accelerated molecular dynamics simulations wet experiments, we elucidate underlying mechanism abnormal functioning FgMyoIC423D mutant at atomistic level. Our results suggest that damaging exhibits a synergistic similar but more robust than phenamacril, including...
5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS), as an indispensable enzyme in the shikimate pathway, is specific target of grasser killer glyphosate (GPJ). GPJ a competitive inhibitor phosphoenolpyruvate (PEP), which natural substrate EPSPS. A novel Ls-EPSPS gene variant discovered from Liliaceae, named ELs-EPSPS, includes five distal mutations, E112V, D142N, T351S, D425G, and R496G, endowing high insensitivity. However, implicit molecular mechanism enhanced tolerance/insensitivity...
Abstract Biological membranes (biomembranes) are one of the most complicated structures that allow life to exist. Investigating their structure, dynamics, and function is crucial for advancing our knowledge cellular mechanisms developing novel therapeutic strategies. However, experimental investigation many biomembrane phenomena challenging due compositional structural complexity, as well inherently multi‐scalar features. Computational approaches, particularly molecular dynamics (MD)...
Parathyroid hormone (PTH) is an endogenous ligand that activates the PTH type 1 receptor (PTH1R) signaling. Ca2+, a common second messenger, acts as allosteric regulator for prolonging activation of PTH1R. However, clear picture underlying mechanism still missing. Herein, extensive molecular dynamics (MD) simulations are performed PTH1R-PTH complexes with and without Ca2+ ions, allowing us to delineate details calcium-induced allostery. Our results indicate acidic residues in extracellular...
Phenamacril (PHA) is a highly selective fungicide for controlling fusarium head blight (FHB) mainly caused by
Methicillin-resistant Staphylococcus aureus (MRSA) acquires high-level resistance against β-lactam antibiotics by expressing penicillin-binding protein 2a (PBP2a). PBP2a is a cell wall-synthesizing whose closed active site exhibits reduced binding affinity toward antibiotics. Ceftaroline (CFT), fifth-generation cephalosporin, can effectively inhibit the activity to an allosteric trigger opening, allowing second CFT access site. However, essential mechanism behind behavior of remains unclear....
Abstract Background Myosin plays a crucial role in cellular processes, while its dysfunction can lead to organismal malfunction. Phenamacril (PHA), highly species‐specific and non‐competitive inhibitor of myosin I (FgMyoI) from Fusarium graminearum , has been identified as an effective fungicide for controlling plant diseases caused by partial pathogens, such wheat scab rice bakanae. However, the molecular basis action is still unclear. Results This study used multiple computational...
Kabuki syndrome (KS) or Niikawa-Kuroki is a sporadic disorder characterized by postnatal growth retardation, developmental delay, mild to moderate and characteristic facial appearance. Cardiovascular defects, clefts of the lip, palate, both, musculoskeletal abnormalities occur in about 50% patients with KS. The cause this multiple congenital anomaly unknown, investigators have speculated that KS contiguous gene-deletion syndrome. Based on presence heart defects KS, it was suggested might...
The parathyroid hormone type 1 receptor (PTH1R), a canonical class B GPCR, is regulated by positive allosteric modulator, extracellular Ca2+. Calcium ions prolong the residence time of PTH on PTH1R, leading to increased activation and duration cAMP signaling. But essential mechanism behavior PTH1R not fully understood. Here, extensive molecular dynamics (MD) simulations are performed for PTH1R–G-protein combinations with without Ca2+ describe how calcium allosterically engage...
We report on an 8-year-old girl with unbalanced 15;22 translocation and manifestations of DiGeorge syndrome (DGS), velocardiofacial (VCFS), other abnormalities. The main our patient were feeding difficulties, respiratory infections, short stature, peculiar face hypertelorism, prominent nose, abnormal ears, microstomia crowded teeth, broad neck shield chest pectus deformity widely spaced nipples fat distribution, heart defect, scoliosis, asymmetric limb development, hands feet, hyperchromic...
Amitraz is one of the critical acaricides/insecticides for effective control pest infestation Varroa destructor mite, a devastating parasite Apis mellifera, because its low toxicity to honeybees. Previous assays verified that typical G protein-coupled receptor, β-adrenergic-like octopamine receptor (Octβ2R), unique target amitraz, but honeybee Octβ2R resists amitraz. However, underlying molecular mechanism enhanced sensitivity or amitraz mutated Octβ2RE208V/I335T/I350V not fully understood....
At present, the biomarkers which can predict clinical efficacy of allergen immunotherapy (AIT) are still much debated. IgE levels often related to allergic severity. Therefore, this study aimed at relating total (tIgE) with AIT assessed by symptoms and drug score skin prick test (SPT) response.We evaluated 81 children who had received house-dust mite (HDM) subcutaneous for three years. According tIgE before treatment, all were divided into high value, medium value low group. Each group...
Abstract The identification and quantization of traditional Chinese medicine (TCM) are a challenge for researchers industry. Using untargeted analytical methods, the in vivo detection TCM compounds difficult because significant interference endogenous substances. Fortunately, ongoing development new technologies, especially Q‐Orbitrap–MS, offers some solutions. Our team developed holistic MS method, combining data‐dependent 2 (dd‐MS ) modes to extensively identify prototypes vivo. method was...