A5100687202- Plant Disease Resistance and Genetics
- Cephalopods and Marine Biology
- Plant biochemistry and biosynthesis
- Plant Virus Research Studies
- Computational Drug Discovery Methods
- Protein Structure and Dynamics
- Soybean genetics and cultivation
- Genetic diversity and population structure
- CRISPR and Genetic Engineering
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Glioma Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- DNA Repair Mechanisms
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Identification and Quantification in Food
- Essential Oils and Antimicrobial Activity
- Glycosylation and Glycoproteins Research
- Protein Degradation and Inhibitors
- Enzyme Catalysis and Immobilization
- Heat shock proteins research
- Fungal Plant Pathogen Control
- Genomics and Chromatin Dynamics
- Microstructure and Mechanical Properties of Steels
Macao Polytechnic University
2023-2025
Anhui Agricultural University
2024
Fudan University
2022-2024
Zhongshan Hospital
2022-2024
Jiangsu Vocational College of Medicine
2024
Charité - Universitätsmedizin Berlin
2024
Wuhan Polytechnic University
2018-2023
Guilin University of Technology
2023
Anhui University
2023
China Academy of Chinese Medical Sciences
2023
Summary The saponins of the model legume Medicago truncatula are glycosides at least five different triterpene aglycones: soyasapogenol B, E, medicagenic acid, hederagenin and bayogenin. These aglycones most likely derived from β‐amyrin, a product cyclization 2,3‐oxidosqualene. Mining M. EST data sets led to identification sequences putatively encoding three early enzymes aglycone formation: squalene synthase (SS), epoxidase (SE), β‐amyrin (β‐AS). SS was functionally characterized by...
We report herein the design, synthesis, and evaluation of macrocyclic peptidomimetics that bind to WD repeat domain 5 (WDR5) block WDR5-mixed lineage leukemia (MLL) protein-protein interaction. Compound 18 (MM-589) binds WDR5 with an IC50 value 0.90 nM (Ki <1 nM) inhibits MLL H3K4 methyltransferase (HMT) activity 12.7 nM. potently selectively cell growth in human lines harboring translocations is >40 times better than previously reported compound MM-401. Cocrystal structures 16 complexed...
Panax notoginseng is famous for its important therapeutic effects. Saponins are bioactive compounds found in different parts and developmental stages of P. plants. Thus, it urgently to study saponins distribution growth ages In this study, potential biomarkers were found, their chemical characteristic differences revealed through metabolomic analysis. High-performance liquid chromatography data indicated the higher content (i.e., Rg1, Re, Rd, Rb1) underground than that aerial parts....
Abstract Artemisia annua plants produce a broad range of volatile compounds, including monoterpenes, which contribute to the characteristic fragrance this medicinal species. A cDNA clone, QH6, contained an open reading frame encoding 582-amino acid protein that showed high sequence identity plant monoterpene synthases. The prokaryotically expressed QH6 fusion converted geranyl diphosphate (−)-β-pinene and (−)-α-pinene in 94:6 ratio. was predominantly juvenile leaves 2 weeks postsprouting....
Protein–protein interactions (PPIs) are an important category of putative drug targets. Improvements in high-throughput screening (HTS) have significantly accelerated the discovery inhibitors for some categories PPIs. However, methods suitable multiprotein complexes (e.g. those composed three or more different components) been slower to emerge. Here, we explored approach that uses reconstituted (RMPCs). As a model system, chose heat shock protein 70 (Hsp70), which is ATP-dependent molecular...
Cell death-inducing proteins (CDIPs) play important roles in the infection of Botrytis cinerea, a broad host-range necrotrophic phytopathogen. Here, we show that secreted protein BcCDI1 (Cell Death Inducing 1) can cause necrosis tobacco leaves and at same time elicit plant defense. The transcription Bccdi1 was induced stage. Deletion or overexpression resulted no notable change disease lesion on bean, tobacco, Arabidopsis leaves, indicating has effect final outcome B. cinerea infection....
The Begonia species are common shade plants that mostly found in southwest China. They have not been well studied despite their medicinal and decorative uses because gene penetration, decreased adaptability, restricted availability all caused by frequent interspecific hybridization.To understand the patterns of mutation chloroplast genomes different Begonia, as evolutionary relationships, we collected seven China sequenced genomes. exhibit a quadripartite structure (157,634 - 169,694 bp),...
The lethal mutation C423D in Fusarium graminearum myosin I (FgMyoI) occurs close to the binding pocket of allosteric inhibitor phenamacril and causes severe inhibition on mycelial growth F. strain PH-1. Here, based extensive Gaussian accelerated molecular dynamics simulations wet experiments, we elucidate underlying mechanism abnormal functioning FgMyoIC423D mutant at atomistic level. Our results suggest that damaging exhibits a synergistic similar but more robust than phenamacril, including...
Abstract Disulfide bonds, covalently formed by sulfur atoms in cysteine residues, play a crucial role protein folding and structure stability. Considering their significance, artificial disulfide bonds are often introduced to enhance thermostability. Although an increasing number of tools can assist with this task, significant amounts time resources wasted owing inadequate consideration. To the accuracy efficiency designing for thermostability improvement, we initially collected bond data...
Shelterin, a six-protein complex, plays fundamental role in protecting both the length and stability of telomeres. Repressor activator protein 1 (RAP1) telomeric repeat-binding factor 2 (TRF2) are two subunits shelterin that interact with each other. Small-molecule inhibitors block RAP1/TRF2 protein–protein interaction can disrupt structure may be employed as pharmacological tools to investigate biology shelterin. On basis cocrystal we have developed first-in-class triazole-stapled peptides...
Species delimitation by traditional morphological methods is challenging in cephalopods due to their flexible bodies, changeable pigment traits, and sometimes high homoplasy. Molecular information provides important assistance for taxonomic decision. In this study, we applied three species on 132 from 7 families along Chinese waters, found anunderestimated diversity these taxa. A maximum of 56 molecular operational units was detected, possible cryptic diversities were revealed Loliolus beka...
Although microstructure optimization is an effective strategy to improve and regulate electromagnetic wave (EMW) absorption properties, preparing microwave absorbents with enhanced EMW absorbing performance tuned band by a simple method remains challenging. Herein, ZnIn2S4/reduced graphene oxide (rGO) composites flower-like cloud-like morphologies were fabricated convenient hydrothermal method. The ZnIn2S4/rGO different realize efficient tunable bands, covering wide frequency range....
The external morphology and morphological variations of Sepiella inermis vary across regions, necessitating investigation. However, the histological information on subcutaneous gland has been insufficient to describe it. In this study, specimens were systematically collected characterized from Gulf Thailand. Regarding morphology, female cuttlebones exhibit greater width more pronounced curves compared males, while males feature 17–19 white dots along fin margins. presence was discerned...