A5102717432- Invertebrate Immune Response Mechanisms
- RNA Research and Splicing
- Neurobiology and Insect Physiology Research
- Peroxisome Proliferator-Activated Receptors
- Insect symbiosis and bacterial influences
- RNA modifications and cancer
- Phytochemistry and Biological Activities
- Insect Resistance and Genetics
- Genomics and Phylogenetic Studies
- Aquaculture disease management and microbiota
- Plant and Fungal Species Descriptions
- Digestive system and related health
- SARS-CoV-2 detection and testing
- Ethnobotanical and Medicinal Plants Studies
- Genetic factors in colorectal cancer
- Video Surveillance and Tracking Methods
- Advanced Vision and Imaging
- Ginseng Biological Effects and Applications
- Cholinesterase and Neurodegenerative Diseases
- Advanced Optical Sensing Technologies
- Plant biochemistry and biosynthesis
- Silkworms and Sericulture Research
- Insect-Plant Interactions and Control
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
Oklahoma State University
2022-2025
Wuhan Polytechnic University
2022-2024
Sichuan University
2021-2023
Oklahoma State University Oklahoma City
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2022
Jiujiang First People's Hospital
2022
Southwest Medical University
2021
Chinese University of Hong Kong, Shenzhen
2021
State Key Laboratory of Biotherapy
2021
Shanghai Center for Brain Science and Brain-Inspired Technology
2021
The lesser grain borer, Rhyzopertha dominica (F.) (Coleoptera: Bostrichidae), is a major global pest of cereal grains. Infestations are difficult to control as larvae feed inside kernels, and many populations resistant both contact insecticides fumigants. We sequenced the genome R. identify genes responsible for important biological functions develop more targeted efficacious management strategies. was assembled from long read sequencing long-range scaffolding technologies. assembly 479.1...
Abstract Dysfunctions of ATP-binding cassette, subfamily D, member 1 (ABCD1) cause X-linked adrenoleukodystrophy, a rare neurodegenerative disease that affects all human tissues. Residing in the peroxisome membrane, ABCD1 plays role translocation very long-chain fatty acids for their β-oxidation. Here, six cryo-electron microscopy structures four distinct conformational states were presented. In transporter dimer, two transmembrane domains form substrate pathway, and nucleotide-binding site...
The Begonia species are common shade plants that mostly found in southwest China. They have not been well studied despite their medicinal and decorative uses because gene penetration, decreased adaptability, restricted availability all caused by frequent interspecific hybridization.To understand the patterns of mutation chloroplast genomes different Begonia, as evolutionary relationships, we collected seven China sequenced genomes. exhibit a quadripartite structure (157,634 - 169,694 bp),...
Serine esterases (SEs) are hydrolases that catalyze the conversion of carboxylic esters into acids and alcohols. Lipases carboxylesterases constitute two major groups SEs. Although over a hundred insect genomes known, systematic identification classification SEs rarely performed, likely due to large size complex composition gene family in each species. Considering their key roles lipid metabolism other physiological processes, we have categorized 144 M. sexta SE homologs (SEHs), 114 which...
The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants has posed a serious global public health emergency. Therapeutic interventions or vaccines are urgently needed to treat prevent the further dissemination of this contagious virus. This study described identification neutralizing receptor-binding domain (RBD)-specific antibodies from mice through vaccination with recombinant SARS-CoV-2 RBD. RBD-targeted monoclonal (mAbs) distinct...
Colorectal cancer (CRC) is the third most prevalent disease in world, with an estimated 1.2 million new cases each year. Spontaneous CRCs account for around 70% of all CRCs, are caused by somatic mutations. Minor variations or single-nucleotide polymorphisms (SNPs) oncogene tumor-suppressor genes cause familial CRC. MSH2 and MSH6 located on chromosome 2. These products involved repair DNA replication defects. If these proteins changed, errors not rectified, resulting damaged leading to...
To elucidate the genetic information and evolutionary relationships of
Aesculus chinensis belongs to Hippocastanaceae family,bears medicinal and ornamental values. The oleanane type triterpenoid saponin aescin is regarded as active ingredient accumulated in seed. In order understand its molecular basis of the biosynthesis,we used high-throughput sequencing under Illumina Hi Seq 2000 platform obtain transcriptome data seed flower from A. further mine genes involved metabolic pathway. Unigene's de novo splicing was performed using Trinity software; results were...
Abstract The malfunction of ABCD1 causes X-linked adrenoleukodystrophy (X-ALD), a rare neurodegenerative disease that affect all tissues in human. Residing the peroxisome membrane, plays role translocation very long chain fatty acids (VLCFA) for their damage by β-oxidation. Here, we present five Cryo-Electron microscopy structures four conformational states. Combined with functional analysis, found substrate and ATP trigger closing two nucleotide binding domains (NBDs) over distance 40 Å...
The immune system of Manduca sexta has been well studied to understand molecular mechanisms insect antimicrobial responses. While evidence supports the existence major signaling pathways in this species, it is unclear how induced production defense proteins specifically regulated by Toll and Imd pathways. Our previous studies suggested that diaminopimelic acid-type peptidoglycans (DAP-PG) from Gram-negative some Gram-positive bacteria, more than Lys-type (Lys-PG) other triggers both through...
Background objects obscured in some sub-apertures of light-field cameras can be seen by other sub-apertures. Consequently, occluded surfaces are possible to reconstructed from LF images. So far, Current foreground occlusion elimination approaches based on usually extract only the complementary information about background among different sub-aperture images get an occlusion-free center view, which cannot ideal performances reconstructing visually realistic and semantically plausible pixels...
Abstract The malfunction of ABCD1 causes X-linked adrenoleukodystrophy (X-ALD), a rare neurodegenerative disease that affect all tissues in human. Residing the peroxisome membrane, plays role translocation very long chain fatty acids (VLCFA) for their damage by β-oxidation. Here, we present five Cryo-Electron microscopy structures four conformational states. Combined with functional analysis, found substrate and ATP trigger closing two nucleotide binding domains (NBDs) over distance 40 Å...