A5016059940- Invertebrate Immune Response Mechanisms
- Neurobiology and Insect Physiology Research
- Insect Resistance and Genetics
- Plant-Microbe Interactions and Immunity
- Insect symbiosis and bacterial influences
- Lepidoptera: Biology and Taxonomy
- RNA Research and Splicing
- Tuberculosis Research and Epidemiology
- Plant Disease Resistance and Genetics
- Plant Pathogens and Resistance
- Machine Learning in Bioinformatics
- Mycobacterium research and diagnosis
- Tissue Engineering and Regenerative Medicine
- Listeria monocytogenes in Food Safety
- Genetics, Bioinformatics, and Biomedical Research
- Bioinformatics and Genomic Networks
- Invertebrate Taxonomy and Ecology
- Insect Utilization and Effects
- Species Distribution and Climate Change
- Studies on Chitinases and Chitosanases
- Advanced biosensing and bioanalysis techniques
- Identification and Quantification in Food
- Autism Spectrum Disorder Research
- Biosensors and Analytical Detection
- Essential Oils and Antimicrobial Activity
National Institute for Communicable Disease Control and Prevention
2016-2025
Heilongjiang Center for Tuberculosis Control and Prevention
2018-2025
Sichuan Academy of Agricultural Sciences
2025
Chinese Center For Disease Control and Prevention
2023-2024
Zhujiang Hospital
2022-2024
Panyu Hospital of Chinese Medicine
2024
Rutgers, The State University of New Jersey
2019-2024
Southern Medical University
2022-2024
Guangzhou Medical University
2024
Center for Disease Control
2023
Summary mi RNA s contribute to plant resistance against pathogens. Previously, we found that the function of miR398b in immunity rice differs from Arabidopsis. However, underlying mechanisms are unclear. In this study, characterized mutants target genes and demonstrated multiple superoxide dismutase miR398b‐regulated blast fungus Magnaporthe oryzae . Out four miR398b, mutations Cu/Zn‐Superoxidase Dismutase1 ( CSD 1 ), 2 Os11g09780 Superoxide DismutaseX , SODX ) led enhanced M. increased...
miR169 is a conserved microRNA (miRNA) family involved in plant development and stress-induced responses. However, how functions rice immunity remains unclear. Here we show that acts as negative regulator against the blast fungus Magnaporthe oryzae by repressing expression of Nuclear Factor Y-A (NF-YA) genes. The accumulation was significantly increased susceptible accession but slightly fluctuated resistant upon M. infection. Consistently, transgenic lines overexpressing miR169a became...
Fitness cost is a common phenomenon in rice blast disease-resistance breeding. MiR396 highly conserved microRNA (miRNA) family targeting Growth Regulating Factor (OsGRF) genes. Mutation at the target site of miR396 certain OsGRF gene or blocking expression leads to increased grain yield. Here we demonstrated that fitness can be trade-off miR396-OsGRFs module via balancing growth and immunity against fungus. The accumulation isoforms was significantly susceptible accession, but fluctuated...
Abstract MicroRNAs (miRNAs) play important roles in rice response to Magnaporthe oryzae , the causative agent of blast disease. Studying miRNAs is great significance for disease control. Osa‐miR167d belongs a conserved miRNA family targeting auxin responsive factor ( ARF ) genes that act developmental and stress‐induced responses. Here, we show plays negative role immunity against M. by suppressing its target gene. The expression was significantly suppressed resistant accession at after 24 h...
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There is currently a lack of efficacious treatments for patients with chemo-resistant small-cell lung cancer (SCLC), leading to poor prognoses. We examined SCLC cell line using genome-wide CRISPR/Cas9 screening and identified serine/threonine kinase division cycle 7 (CDC7) as potential synergistic target. Silencing CDC7 in cells decreased the IC50 improved efficacy chemotherapy. Based on highest single agent model, inhibitor XL413 had effect both cisplatin etoposide cells, but no such...
Rice blast caused by Magnaporthe oryzae (M. oryzae) is a major threat to global rice production. In recent years, small interference RNAs (siRNAs) and host-induced gene silencing (HIGS) has been shown be new strategies for the development of transgenic plants control fungal diseases proved useful tool study function in pathogens. We here tested whether vitro feeding artificial siRNAs (asiRNAs) could compromise M. virulence vivo HIGS technique improve resistance. Our data revealed that...
Significance Phenoloxidase-catalyzed melanization and Spätzle-triggered Toll signaling are critical innate immune responses of insects that triggered by specific proteolysis. It has been unclear whether separate protease cascades or an integrated network serine proteases coordinates these responses. Here we present evidence hemolymph HP5 acts in pathways eliciting activation both phenoloxidase Spätzle-1 Manduca sexta . a unique specificity cleaving proHP6 at His 112 , resulting HP6...
Morchella is an edible mushroom with medical applciations. To explore the correlation between texture indices of and to establish a sensory quality evaluation system, characteristics 214 germplasm resources from our country were analyzed via Texture Profile Analysis (TPA) method on analyzer. The research revealed significant differences in both pileus stipe among populations. After Kolmogorov–Smirnov test, six seen conform normal distribution. According analysis, there was pileus, positive...
Diabetes mellitus (DM) is a major risk factor for tuberculosis (TB), However, limited research exists on their clinical and strain characteristics. This study aims to investigate the correlation between these factors in TB-DM patients Changping District. Whole genome sequencing (WGS) drug susceptibility tests (DST) were performed culture-positive strains. Spearman analysis was used examine lineage, cavities, hemoptysis population. The specificity, sensitivity, confidence intervals predicting...
Abstract Ascomycetes fungi are often prone to degeneration. Agricultural production of the prized ascomycete mushroom Morchella importuna (black morel) typically suffers from reduced yield and malformed ascocarps owing culture This study compared M. cultures subjected five different long‐term preservation treatments, using transcriptomics metabolomics. Avoiding repeated subculturing in combination with nutrient‐limited conditions was found be most beneficial method for maintaining fruiting...
The use of immune checkpoint inhibitors (ICI) can lead to immune-related adverse events (irAE), which skin irAE is common, affecting up 50% ICI-treated patients. Although only a few cases subacute cutaneous lupus erythematosus (SCLE) have been reported in patients receiving anti-programmed death-1(anti-PD-1) immunotherapy, it important identify ICI-induced SCLE because may cause delayed and/or prolonged reactions even after treatment discontinuation. To date, no associated with Camrelizumab...