A5101609393- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- Cancer Cells and Metastasis
- Bone and Joint Diseases
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Infection Control and Ventilation
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- Bone Metabolism and Diseases
- Immune Cell Function and Interaction
- Periodontal Regeneration and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Building Energy and Comfort Optimization
- COVID-19 epidemiological studies
- Neonatal Respiratory Health Research
- CAR-T cell therapy research
- Immune cells in cancer
- Fungal Biology and Applications
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Bone health and treatments
- Management of metastatic bone disease
China North Industries Group Corporation (China)
2024
Sichuan University
2019-2023
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2010-2023
Beijing Institute of Education
2018-2023
Northeast Petroleum University
2021
Academy of Military Medical Sciences
1990-2020
Harbin Medical University
2020
First Affiliated Hospital of Harbin Medical University
2020
Nanjing Hydraulic Research Institute
2019
Fujian Normal University
2010-2011
Bone marrow contains a population of rare progenitor cells capable differentiating into osteoblasts, chondrocytes, adipocytes, myoblasts, and hematopoiesis-supporting stromal cells. These cells, referred to as mesenchymal (MPCs), can be purified culture-expanded from animals humans. Using bone-marrow-conditioned medium combined with basic fibroblast growth factor, we cultured relatively homogeneous MPCs murine bone marrow, which uniformly expressed stem cell antigen-1, CD29, CD44, c-kit,...
Abstract Due to the potent immunoregulatory capacity, mesenchymal stem cells (MSCs) have been used in clinical trials treat acute graft-versus-host disease (aGvHD), although detailed vivo mechanisms remain elusive. In a murine lethal aGvHD model, MSCs delayed development of disease. Interestingly, we found that MSC infusion increased number T lymphocytes secondary lymphoid organs (SLOs). Since expression CD62L and CCR7 is prerequisite for lymphocyte migration into SLOs, vitro experiments...
To investigate the therapeutic effect of intercellular adhesion molecule (ICAM)-1-modified mesenchymal stem cells (MSCs) in a mouse model inflammatory bowel disease (IBD) induced by dextran sulfate sodium. Primary MSCs and ICAM-1-overexpressing (C3 cells) were generated vitro. The IBD was with drinking water containing sodium for 7 days. For cell therapy, mice randomly assigned to six experimental groups: control group, primary MSC C3 C3-vector C3-ICAM-1 group. Mice given single injection 1...
Abstract In contrast to the considerable amount of data that documents biological properties mesenchymal progenitor cells from human and other species, there is still paucity information about mouse counterparts, as their purification culture expansion procedures remain rudimentary. present study, murine cell (muMPC) was developed by explant collagenase-digested bone fragments after removal released cells. During cultivation, fibroblastoid sprouted migrated fragments, followed adherent...
Abstract Inefficient homing of systemically infused mesenchymal stem cells (MSCs) limits the efficacy existing MSC-based clinical graft-versus-host disease (GvHD) therapies. Secondary lymphoid organs (SLOs) are major niches for generating immune responses or tolerance. MSCs home to a wide range organs, but rarely SLOs after intravenous infusion. Thus, we hypothesized that targeted migration into may significantly improve their immunomodulatory effect. Here, chemokine receptor 7 (CCR7) gene,...
Abstract A numerical optimization algorithm utilizing the eighth kind fractional Chebyshev wavelets (EFCWs) in conjunction with Whale Optimization Algorithm (WOA) is developed for solving time-fractional telegraph equations. First, EFCWs are constructed based on polynomials. Subsequently, several properties of analyzed detail, including convergence analysis wavelet expansions and error estimation. Following this, integration formulas derived under Riemann-Liouville integral framework....
Shockwaves and mesenchymal stem cells (MSCs) have been widely accepted as useful tools for many orthopedic applications. However, the modulatory effects of shockwaves on MSCs remain controversial. In this study, we explored influence radial human bone marrow using a floating model in vitro evaluated healing these cartilage defects vivo rabbit model. were cultured vitro, harvested, resuspended, treated with various doses system. Cell proliferation was by growth kinetics Counting Kit-8 (CCK-8)...
The use of immune checkpoint inhibitors (ICI) can lead to immune-related adverse events (irAE), which skin irAE is common, affecting up 50% ICI-treated patients. Although only a few cases subacute cutaneous lupus erythematosus (SCLE) have been reported in patients receiving anti-programmed death-1(anti-PD-1) immunotherapy, it important identify ICI-induced SCLE because may cause delayed and/or prolonged reactions even after treatment discontinuation. To date, no associated with Camrelizumab...
In the current study, we screened effects of different concentrations platelet-rich plasma (PRP) on mesenchymal stem cell (MSC) proliferation and differentiation. Our data demonstrated that concentrated PRP exerted osteogenic, adipogenic, chondrogenic differentiation human bone marrow-derived MSCs. Meanwhile, optimized for each these lineage MSC expansion and, thus, suggested several promising clinical strategies kinds diseases. These findings may help explain controversial MSCs improve...