A5100602517- Mesenchymal stem cell research
- Temporomandibular Joint Disorders
- Cancer Cells and Metastasis
- Oral and Maxillofacial Pathology
- Tissue Engineering and Regenerative Medicine
- Liver physiology and pathology
- Cancer, Hypoxia, and Metabolism
- Bone Tumor Diagnosis and Treatments
- Adipose Tissue and Metabolism
- Bone Metabolism and Diseases
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Osteoarthritis Treatment and Mechanisms
- Bone and Dental Protein Studies
- Periodontal Regeneration and Treatments
- Hematopoietic Stem Cell Transplantation
- Neonatal Respiratory Health Research
- Pancreatic function and diabetes
- Ion Channels and Receptors
- T-cell and B-cell Immunology
- Data Quality and Management
- Cardiac Fibrosis and Remodeling
- Osteomyelitis and Bone Disorders Research
- Bone and Joint Diseases
- Cancer-related molecular mechanisms research
Peking University
2014-2025
National Clinical Research Center for Digestive Diseases
2023-2025
First Affiliated Hospital Zhejiang University
2024
Zhejiang University
2024
Stomatology Hospital
2017-2022
University of Pennsylvania
2007-2020
Shaanxi Provincial People's Hospital
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
China Academy of Chinese Medical Sciences
2018
King University
2016-2017
To characterize different tissue MSCs as sources of cell immunomodulatory therapy. Examined the effects IFN-γ on WJ-MSC and their function characteristics. We compared human fetal bone marrow (F-BM), adipose (AT), Warton's Jelly-derived (WJ-MSCs) for surface antigen expression, differentiation ability, proliferation capacity, clonality, tolerance aging, gene whether affected determined by real time quantitative PCR. Fifteen geneswere examined. further assess WJ-MSCs-mediated peripheral blood...
Many modern data science applications build on lakes, schema-agnostic repositories of files and products that offer limited organization management capabilities. There is a need to lake search capabilities into environments, so scientists analysts can find tables, schemas, workflows, datasets useful their task at hand. We develop solutions for the Jupyter Notebook platform, enable augment training data, potential features extract, clean joinable or linkable tables. Our core methods also...
Tubeimoside-1 (TBMS1) is a natural compound isolated from tubeimoside, which has been widely used as traditional Chinese herbal medicine. The purpose of the present study to investigate anti-tumor effect and underling mechanism TBMS1 on glioma cancer cells.The MTT assay was performed evaluate cell proliferation. fluorescent microscopy flow cytometry analysis were apoptosis. Western blot protein change.TBMS1 inhibited proliferation in dose- time-dependent manner. Fluorescent demonstrated that...
Abstract Fracture healing, in which osteoclasts and osteoblasts play important roles, has drawn much clinical attention. Osteoclast deficiency or decreased osteoblast activity will impair fracture healing. TRPV1 is a member of the Ca 2+ permeable cation channel subfamily, pharmacological inhibition prevents ovariectomy-induced bone loss, makes potential target for osteoporosis. However, whether long term deletion affect healing process unclear. In this study, we found that wild-type mice...
Abstract Mesenchymal stem cells (MSCs) are multipotential residing in the bone marrow. Several studies have shown that mechanical stimulation modulates MSC differentiation through mobilization of second messengers, but mechanism mechanotransduction remains poorly understood. In this study, using fluorescence and laser confocal microcopy as well patch-clamp techniques, we identified transient receptor potential melastatin type 7 (TRPM7) channel key involved marrow MSCs. TRPM7 knockdown...
Abstract Acute and chronic graft-versus-host disease (GVHD) remain the major complications limiting efficacy of allogeneic hemopoietic stem cell transplantation. Chronic GVHD can evolve from acute GVHD, or in some cases may overlap with but how evolves to is unknown. In this study, a classical CD8+ T cell-dependent mouse model, we found that pathogenic donor CD4+ cells developed engrafted (HSCs) C57BL/6SJL(B6/SJL, H-2b) mice suffering after receiving HSCs C3H.SW (H-2b). These were activated,...
Health is dependent on the homeostasis of both inner and external microenvironments. The microbiota as microenvironment plays a critical role in regulation several organ systems mammals. However, it unclear whether regulates skeletal system bone marrow mesenchymal stem cells (BMMSCs). Here, using well-established germ-free (GF) mouse model, we show that significantly alters stemness BMMSCs comparison to specific-pathogen-free (SPF)-derived BMMSCs. Colonization GF mice with SPF...
Abstract This study aimed to describe the clinical features of different types traumatic temporomandibular joint (TMJ) ankylosis. Seventy-one patients with 102 ankylosed joints were retrospectively reviewed and categorized into four groups according grades severity: type I, non-bony ankylosis almost-normal space; II, lateral bony marked by a normal space that coexists radiolucent line; III, complete characterized only IV, extensive without any line. The period ankylosis, maximal mouth...
Microbiota and their metabolites short-chain fatty acids (SCFAs) have important roles in regulating tissue regeneration mesenchymal stem cell (MSC) differentiation. In this study, we explored the potential effects of SCFAs on murine incisor dental MSCs. We observed that SCFA deficiency induced by depletion microbiota through antibiotic treatment led to lower renewal rate delayed dentinogenesis mice incisors. Supplementation with drinking water during can rescue effectively. vitro,...
Mesenchymal stem cells (MSCs) possess promising potential in tissue engineering and regenerative medicine. Previous studies demonstrated that spheroid formation of MSCs exhibited improved stemness maintenance therapeutic compared with monolayer culture. To date, various culture systems have been developed but most them required low adhesion conditions or special equipment. In this study, we inoculation dissociated TeSR-E8 medium could induce self-assemble conventional polystyrene dishes....
Abstract To investigate the effects of Nd: YAG (1064 nm) photobiomodulation on multilineage differentiation and immunomodulation potentials adipose tissue-derived stem cells (ADSCs) in vitro vivo. For experiments, were divided into control group (non-irradiated ADSCs) groups. 0.5 J/cm 2 , 1 4 used for proliferation assays; ADSCs adipogenic assays, applied; was migration assays. The abilities assessed by qPCR, Oil Red O staining, Alizarin staining. potential qPCR human cytokine array....
Exosomes from mesenchymal stromal cells (MSCs) can prevent the development of medication-related osteonecrosis jaw (MRONJ) by promoting tooth socket wound healing; however, exact mechanism remains to be clarified. In this study, our aim was explore mechanisms exosomes derived adipose-derived (ADSCs) in preventing MRONJ focusing on macrophage M1 polarization and pyroptosis. The model established administration zoledronate extraction. isolated supernatant ADSCs were mixed with hydrogel locally...