A5103269732- Magnetic confinement fusion research
- Ionosphere and magnetosphere dynamics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Eosinophilic Disorders and Syndromes
- Salivary Gland Tumors Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Lipids, and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Advanced Semiconductor Detectors and Materials
- Biochemical Analysis and Sensing Techniques
- Solar and Space Plasma Dynamics
- Medical Imaging Techniques and Applications
- Gastrointestinal motility and disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Semiconductor Quantum Structures and Devices
- Advanced X-ray and CT Imaging
- Cancer-related molecular mechanisms research
- Ion channel regulation and function
- Particle accelerators and beam dynamics
- Neuropeptides and Animal Physiology
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
Lanzhou University Second Hospital
2017-2025
Beihang University
2025
Lanzhou University
2017-2025
Hong Kong Polytechnic University
2024-2025
Xuzhou Medical College
2024
First Hospital of Lanzhou University
2023
China Medical University
2023
Zhejiang University
2019
Sichuan University of Arts and Science
2015-2018
Capital Medical University
1992-2015
1 The vagus nerve conveys primary afferent information produced by a meal to the brainstem. Serotonin (5-HT), which abounds in intestinal enterochromaffin cells, is released response various stimuli. We have recently demonstrated that 5-HT from cells activates 5-HT3 receptors on vagal fibres mediate luminal non-cholecystokinin-stimulated pancreatic secretion. present study was designed evaluate responses of sensory neurons intraluminal osmotic stimulation and infusion maltose, glucose or...
Excessive formation of neutrophil extracellular traps (NETs) may lead to myositis-related interstitial lung disease (ILD). There is evidence that NETs can directly injure vascular endothelial cells and play a pathogenic role in the inflammatory exudation ILD. However, specific mechanism unclear. This study aimed investigate underlying NET-induced injury human pulmonary microvascular (HPMECs). HPMECs were stimulated with (200 ng/ml) vitro. Cell death was detected by propidium iodide staining....
Idiopathic inflammatory myopathy (IIM) is a progressive autoimmune disease characterized by interstitial lung (ILD) with limited therapeutics available. Pirfenidone (PFD), medication utilized for the treatment of idiopathic pulmonary fibrosis, exhibits notable antioxidant, anti-inflammatory and inhibition collagen synthesis. This study aims to clarify its efficacy mechanism in treating IIM-ILD. A murine myositis-associated (MAILD) model was used assess therapeutic effect PFD. The serum...
We recently demonstrated that luminal factors such as osmolality, disaccharides, and mechanical stimulation evoke pancreatic secretion by activating 5-hydroxytryptamine subtype 3 (serotonin-3, 5-HT3) receptors on mucosal vagal afferent fibers in the intestine. hypothesized 5-HT released stimuli acts a paracrine substance, to stimulate secretion. In vivo rat model, perfusion of maltose or hypertonic NaCl increased level threefold intestinal effluent perfusates. Similar levels were observed...
Previous studies have shown that various active components of licorice anticancer effects. However, few investigated the mechanism action in gastric cancer. The effect compounds on biological activity cancer cells was vitro (MKN-45 cells). Network pharmacology and molecular docking were used to predict potential targets against verify binding stability target proteins compounds. In addition, assessed using a mouse model licorice-active component (quercetin) effectively inhibited...
Summary Idiopathic inflammatory myopathies (IIMs) are a group of systemic autoimmune diseases characterized by immune-mediated muscle injury. Abnormal neutrophil extracellular traps (NETs) can be used as biomarker IIM disease activity, but the mechanism NET involvement in IIMs needs to elucidated. Important components NETs, including high-mobility box 1, DNA, histones, matrix, serum amyloid A, and S100A8/A9, act damage-associated molecular patterns (DAMPs) promote inflammation IIMs. NETs on...
The toroidal Alfvén eigenmode (TAE), excited by trapped energetic particles (EPs), is numerically investigated in a tokamak plasma, using the non-perturbative magnetohydrodynamic-kinetic hybrid formulation based MARS-K code (Liu et al 2008 Phys. Plasmas 15 112503). Compared with fixed boundary condition at plasma edge, free enhances critical value of EPs kinetic contribution for driving TAE. Free also induces finite perturbations edge as expected. An anisotropic distribution EPs, particle...
Abstract The excessive formation of neutrophil extracellular traps (NETs) has been demonstrated to be a pathogenic mechanism idiopathic inflammatory myopathy (IIM)-associated interstitial lung disease (ILD). This study aimed answer whether an experimental autoimmune myositis (EAM) model can used IIM-ILD and NETs participate in the development EAM-ILD. An EAM mouse was established using skeletal muscle homogenate pertussis toxin (PTX). relationship between ILD phenotype determined via...
Abstract Our group previously demonstrated that NETs were involved in interstitial lung diseases (ILD) among patients with idiopathic inflammatory myopathies (IIM) and the experimental autoimmune myositis (EAM) mouse model activated fibroblasts through TLR9-miR7-Smad2 axis. This study aimed to establish a novel of myositis-associated disease (MAILD) by using TLR9 agonist (ODN2395). ODN2395 muscle homogenate used induce MAILD BALB/c mice. was evaluated histopathology, immunohistochemistry,...
Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is an active component of many herb-based laxatives. However, its mechanism action unclear. The aim the present study was to investigate role mast cells and enteric neurons in emodin-induced ion secretion rat colon.
Background The functions of the distal colon are regulated by local and extrinsic neural pathways. In previous studies, we have found that dopamine (DA) norepinephrine (NE) could evoke colonic ion transport activating β-adrenoceptors. present study aims to investigate segmental differences in expression activation β-adrenoceptors physiological pathophysiological conditions. Methods Real-time PCR, immunofluorescence, Western blotting were used detect rat human colon. Short-circuit current...
Studies on the interactions of single long non-coding RNA, microRNA, and mRNA have many limitations; therefore, it is necessary to study complex regulatory network gastric cancer (GC) pathogenesis systematically.In this study, gene miRNA expression data for GC were downloaded from The Cancer Genome Atlas used transcriptome profiling, differential analysis, construction an lncRNA-miRNA-mRNA in conjunction with online database identify key genes subnetworks pathogenesis. Real-time quantitative...