A5100414460- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Regulation of Appetite and Obesity
- Memory and Neural Mechanisms
- Vagus Nerve Stimulation Research
- Heart Rate Variability and Autonomic Control
- Gastrointestinal motility and disorders
- Mitochondrial Function and Pathology
- Ion Channels and Receptors
- Stress Responses and Cortisol
- Cardiovascular Function and Risk Factors
- Neural dynamics and brain function
- Adipose Tissue and Metabolism
- EEG and Brain-Computer Interfaces
- Circadian rhythm and melatonin
- Neurogenesis and neuroplasticity mechanisms
- Pancreatic function and diabetes
- Genetic Neurodegenerative Diseases
- Neurotransmitter Receptor Influence on Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Ion channel regulation and function
- Marine and coastal ecosystems
Fudan University Shanghai Cancer Center
2024-2025
Fujian Medical University
2020-2025
Xuzhou Medical College
2015-2025
Chinese Academy of Sciences
2006-2025
Jishou University
2024-2025
Shanghai Chest Hospital
2025
Shanghai Jiao Tong University
2023-2025
Zhejiang Provincial People's Hospital
2025
Shanghai Institute of Organic Chemistry
2025
Tongji Hospital
2025
The development of materials with dual properties high strength and ductility has been a constant challenge since the foundation science discipline. rapid progress nanotechnology in recent decades further brought this to new era. This Research News highlights few newly developed strategies optimize advanced nanomaterials metallic glasses exceptional mechanical ductility. A general concept strain non‐localization is presented describe role multiscale (i.e., macroscale, microscale, nanoscale,...
Implantable bioelectronics provide unprecedented opportunities for real-time and continuous monitoring of physiological signals living bodies. Most adopt thin-film substrates such as polyimide polydimethylsiloxane that exhibit high levels flexibility stretchability. However, the low permeability relatively modulus these thin films hamper long-term biocompatibility. In contrast, devices fabricated on porous show advantages but suffer from patterning density. Here, we report a wafer-scale...
1 The vagus nerve conveys primary afferent information produced by a meal to the brainstem. Serotonin (5-HT), which abounds in intestinal enterochromaffin cells, is released response various stimuli. We have recently demonstrated that 5-HT from cells activates 5-HT3 receptors on vagal fibres mediate luminal non-cholecystokinin-stimulated pancreatic secretion. present study was designed evaluate responses of sensory neurons intraluminal osmotic stimulation and infusion maltose, glucose or...
To further understand the role of peptide hormone gastrin in development and function stomach, we have generated gastrin-deficient mice by gene targeting embryonic stem cells. Mutant were viable fertile, without obvious visible abnormalities. However, gastric was severely affected loss gastrin. Basal acid secretion abolished could not be induced histamine, carbachol, or Histological analysis revealed alterations two cell types primarily involved secretion, parietal enterochromaffin-like...
To establish the mechanism(s) and site(s) of action cholecystokinin (CCK) on pancreatic secretion under physiological conditions, we used an in vivo model using anesthetized rats with pancreaticobiliary cannulas. Infusion CCK-8 (10-160 pmol/kg per h) produced a dose-dependent increase plasma CCK levels. infusion at 40 h level 7.9 +/- 1.5 pM 80% protein output over basal. This was closely approximated by postprandial peak 6.2 1.1 pM. Pretreatment atropine or hexamethonium completely abolished...
Hyperglycemia induces reactive oxygen species (ROS) and apoptosis in cardiomyocytes, which contributes to diabetic cardiomyopathy. The present study was investigate the role of Rac1 ROS production cardiomyocyte during hyperglycemia.Mice with cardiomyocyte-specific knockout (Rac1-ko) were generated. induced Rac1-ko mice their wild-type littermates by injection streptozotocin (STZ). In cultured adult rat high glucose.The results showed a mouse model STZ-induced diabetes, 7 days...
Longer dialysis session length (treatment time, TT) has been associated with better survival among hemodialysis (HD) patients. The impact of TT on clinical markers that may contribute to this advantage is not well known. Using data from the international Dialysis Outcomes and Practice Patterns Study, we assessed association outcomes using both standard regression analyses instrumental variable approaches. study included 37 414 patients in-center HD three times per week prescribed 120 420...
Palonosetron is the only 5-HT<sub>3</sub> receptor antagonist approved for treatment of delayed chemotherapy-induced nausea and vomiting (CINV) in moderately emetogenic chemotherapy. Accumulating evidence suggests that substance P (SP), endogenous ligand acting preferentially on neurokinin-1 (NK-1) receptors, not serotonin (5-HT), dominant mediator emesis. However, palonosetron does bind to NK-1 receptor. Recent data have revealed cross-talk between 5HT<sub>3</sub> signaling pathways; we...
Fructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how transmits lack occupancy by FBP remains unclear. Here, we show that FBP-unoccupied interacts with and inhibits endoplasmic reticulum (ER)-localized transient receptor potential channel subfamily V, inhibiting calcium release in low glucose. The decrease at contact sites between ER lysosome renders inhibited TRPV accessible bind v-ATPase then...
The parabrachial (PB) complex mediates both ascending nociceptive signaling and descending pain modulatory information in the affective/emotional pathway. We have recently reported that chronic is associated with amplified activity of PB neurons a rat model neuropathic pain. Here we demonstrate similar amplification occurs mice, this related to suppressed inhibition lateral (LPB) from CeA animals either sex. Animals after constriction injury infraorbital nerve (CCI-Pain) displayed higher...
With the advancement of world population aging, more attention should be paid to prognosis elderly patients with acute coronary syndrome (ACS). Triglyceride-glucose (TyG) index is a reliable indicator insulin resistance (IR) and closely related traditional risk factors cardiovascular disease (CVD). However, effect TyG on long-term adverse events in ACS has not been reported. This study evaluated prognostic power predicting patients.In this study, 662 > 80 years old who were hospitalized from...
Pain contains both sensory and affective dimensions. We identify the role of norepinephrine in colorectal distention (sub-threshold for acute pain) induced conditioned place avoidance plasticity gene expression anterior cingulate cortex (ACC). Activating locus coeruleus (LC)-projecting ACC neurons facilitates pain-evoked aversive consolidation memory, while inhibiting LC-projecting reversibly blocks it. Optogenetic activation astrocytes behaviour. astrocytic Gi manipulation suppressed...
The sympathoadrenergic system and its major effector PKA (protein kinase A) are activated to maintain cardiac output coping with physiological or pathological stressors. If how plays a role in hypertrophy (PhCH) CH (PaCH) not clear.
The family of WD-repeat proteins comprises over 30 different that share a highly conserved repeating motif [Neer, E. J., Schmidt, C. Nambudripad, R., & Smith, T. F. (1994) Nature 371, 297−300]. Members this include the signal-transducing G protein β subunit, as well other regulate signal transduction, transcription, pre-mRNA splicing, cytoskeletal organization, and vesicular fusion. crystal structure one (Gβ) has now been solved (Wall et al., 1995; Sondek 1996) reveals seven units form...
<h3>Background:</h3> Increasing evidence suggests that chronic stress plays an important role in the pathophysiology of several functional gastrointestinal disorders. We investigated whether cannabinoid receptor 1 (CB1) and vanilloid (TRPV1; transient potential 1) are involved stress-induced visceral hyperalgesia. <h3>Methods:</h3> Male rats were exposed to h water avoidance (WA) daily for 10 consecutive days. The visceromotor response (VMR) colorectal distension (CRD) was measured....
Abnormal behavior of the cardiac ryanodine receptor (RyR2) has been linked to arrhythmias and heart failure (HF) after myocardial infarction (MI). It proposed that protein kinase A (PKA) hyperphosphorylation RyR2 at a single residue, Ser-2808, is critical mediator RyR dysfunction, depressed performance, HF MI.We used mouse model (RyRS2808A) in which PKA Ser-2808 prevented determine whether loss phosphorylation this site averts post MI pump dysfunction.MI was induced wild-type (WT) S2808A...
Hydrothermal vent fluids, cold seep their associated chemosynthetic communities, and the biogeochemical anaerobic oxidation of methane (AOM) play very important roles in sulfur carbon cycles ocean. Based on our previous success developing deploying a deep-sea sediment pore water Raman probe, we developed new hybrid insertion probe (RiP) designed to operate at temperatures up 450 °C that can be inserted directly into high-temperature fluids emerging from hydrothermal vents. By routinely...
Although electrode size should be miniaturized to provide higher selectivity for neural signal recording and avoid tissue damage, small sized electrodes induce high impedance, which decreases quality. In this work, the surface was modified increase effective area lower impedance improve detection quality by optimizing plasma conditions.A tetrafluoromethane (CF4) used of gold sites polyimide-based probes. vitro in vivo stimulation were characterized.For 15 μm diameter (dia.) size, average...