A5051130816- Dialysis and Renal Disease Management
- Parathyroid Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Vitamin D Research Studies
- Central Venous Catheters and Hemodialysis
- Bone health and osteoporosis research
- Neurological and metabolic disorders
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Bone health and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Erythropoietin and Anemia Treatment
- Bone Metabolism and Diseases
- Muscle and Compartmental Disorders
- Ion Transport and Channel Regulation
- Iron Metabolism and Disorders
- Renal function and acid-base balance
- Heart Failure Treatment and Management
- Bone and Joint Diseases
- Vascular Procedures and Complications
- Potassium and Related Disorders
- Blood properties and coagulation
- Cardiovascular Health and Disease Prevention
- Metabolism and Genetic Disorders
- Lipoproteins and Cardiovascular Health
Juntendo University
2023-2025
Juntendo University Urayasu Hospital
2025
National Epilepsy Center
2024
Tokyo Women's Medical University
2004-2017
Toho University
2015-2017
Toho University Medical Center Sakura Hospital
2015-2017
Kindai University
2014
Osaka Medical and Pharmaceutical University
2014
Kindai University Hospital
2014
Koshien University
2014
Background. A well-functioning vascular access (VA) is essential to efficient dialysis therapy. Guidelines have been implemented improving care, yet use varies widely across countries and VA complications remain a problem. This study took advantage of the unique opportunity utilize data from Dialysis Outcomes Practice Patterns Study (DOPPS) examine international trends in patient characteristics practices associated with 1996 2007. DOPPS prospective, observational haemodialysis (HD) outcomes...
Longer dialysis session length (treatment time, TT) has been associated with better survival among hemodialysis (HD) patients. The impact of TT on clinical markers that may contribute to this advantage is not well known. Using data from the international Dialysis Outcomes and Practice Patterns Study, we assessed association outcomes using both standard regression analyses instrumental variable approaches. study included 37 414 patients in-center HD three times per week prescribed 120 420...
Background. Retrospective studies of haemodialysis patients from large dialysis organizations in the United States have indicated that intravenous vitamin D may be associated with a survival benefit. However, prescribed are generally healthier than those who not, suggesting treatment by indication biased previous findings. Additionally, no benefit has been shown recent meta-analysis CKD patients. Because treatment-by-indication bias due to both measured and unmeasured confounders cannot...
Recent studies have shown that the bicarbonate reabsorptive capacity of proximal tubule is increased in metabolic acidosis. For net reabsorption to be regulated, there may changes rate apical H+ secretion as well basolateral base exit step. The present examined Na+/H+ exchange (acridine orange method) and Na+/HCO3 cotransport (22Na uptake) membranes prepared from rabbit renal cortex by sucrose density gradient centrifugation. NH4Cl loading was used produce acidosis (arterial pH, 7.27 +/-...
Background. Optimal waiting time before first use of vascular access is not known. Methods. Two practices—first cannulation for fistulae and grafts, blood flow rate—were examined as potential predictors failure in the Dialysis Outcomes Practice Patterns Study (DOPPS). Access (defined to or salvage intervention) was modelled using Cox regression. Results. Among 309 haemodialysis facilities, 2730 grafts 2154 were studied. For typically occurred within 2–4 weeks at 62% US, 61% European 42%...
Background. Osteoprotegerin (OPG) is a glycoprotein that inhibits osteoclast differentiation and activity. OPG-deficient mice develop severe osteoporosis medial arterial calcification. The expression of OPG detected in early atherosclerotic lesions non-uraemic patients. We examined whether serum associated with aortic calcification haemodialysis
The prognosis for haemodialysis patients is reported to be more favourable in Japan than Europe or North America. Consequently, evaluation of the death predictors considerable interest outside Japan. Patient Registration Committee Japanese Society Dialysis Therapy annually surveys individual patient case mix, laboratory data and important events occurring previous years. Thus, using mix (including Kt/V protein catabolic rate) from 1993 questionnaire survey patients' life/death statistics...
The present studies examined the mechanism of bicarbonate transport across basolateral membrane vesicles prepared from rabbit renal cortex. Isotopic sodium uptake was stimulated by when compared with gluconate (2.5 nmol/mg protein per 5 s versus 1.4 s), and this process inhibited disulfonic stilbenes. Imposition an interior-positive potassium diffusion potential further isotopic to 3.4 s, effect that occurred only in presence blocked Kinetic analysis rate bicarbonate-dependent as a function...
MethodsIn this Phase 3, multicenter, randomized, open-label, parallel-group study, we compared the efficacy and safety of JTT-751 sevelamer hydrochloride in patients undergoing hemodialysis. A total 230 with a serum phosphate ≥1.97 <3.23 mmol/L were randomized to (dose adjusted between 1.5 6.0 g/day) or 3.0 9.0 for 12 weeks. The primary outcome was change from baseline end treatment. Secondary outcomes included changes corrected calcium intact parathyroid hormone (PTH). ferritin, transferrin...
Background. Trends in age-adjusted or age-specific incidence rates of end-stage renal disease (ESRD) have never been examined Japan, a major ESRD epidemic area.
Background. Japanese haemodialysis (HD) patients not only have a very low mortality and hospitalization risk but also haemoglobin (Hb) levels. Internationally, anaemia is associated with mortality, health-related quality of life (QoL) measures HD patients.
Background. Haemodialysis patients were studied in 12 countries to identify practice patterns of prescription antihypertensive agents (AHA) associated with survival.
The evaluation of iron status in dialysis patients provides information essential to the planning adequate recombinant human erythropoietin treatment. cellular can be determined from recently available measurement reticulocyte hemoglobin equivalent (RET-He). RET-He is measured on basis automated fluorescent flow cytometry which channel, using a polymethine dye, also measures mean value forward light scatter intensity mature red blood cells and reticulocytes. These values equate with content....
Intermittent high dose administration of calcitriol or alfacalcidol is effective in suppressing secondary hyperparathyroidism chronic dialysis patients, however calcaemic action these vitamin D derivatives a major obstacle. 22-Oxacalcitriol (OCT) has been reported to have less than calcitriol, while preserving comparable suppressive effect on parathyroid hormone (PTH) secretion. This preliminary study was conducted examine the effects OCT patients. administrated intravenously immediately...
Background. Dialysis-related amyloidosis is one of the chronic complications haemodialysis. We conducted an investigation dialysis-associated in extremely long-term survivors.
Recent reports suggest a cross-sectional association between psychiatric distress and pruritus in patients on haemodialysis (HD). However, no study has examined the likelihood of developing severe HD with depressive symptoms.To evaluate relationship baseline symptoms subsequent risk pruritus.A longitudinal 0.5-2.5-year follow-up period was performed using 1799 who had no/mild at baseline, based Japan Dialysis Outcomes Practice Patterns Study (1996-2004), cohort composed representative sample...